Craniopharyngioma clinical trials
The registry lists 76 studies for Craniopharyngioma across more than 10 countries. 19 are recruiting or about to start. 35 of them are mainly about Craniopharyngioma (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-21.
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Who runs them
St. Jude Children's Research Hospital (5) · West China Hospital (3) · Wake Forest University Health Sciences (3) · Assistance Publique - Hôpitaux de Paris (3) · National Institutes of Health Clinical Center (CC) (3) · Klinikum Oldenburg gGmbH (2) · University of Colorado, Denver (2) · National Cancer Institute (NCI) (2)
What is being tested here
Drugs under test in Craniopharyngioma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tocilizumab | 1 | 0 | 2 |
| Deamino Arginine Vasopressin | 1 | 0 | 1 |
| Semaglutide | 1 | 1 | 1 |
| Tovorafenib | 1 | 0 | 1 |
| Binimetinib | 1 | 0 | 1 |
| Anlotinib | 1 | 0 | 1 |
| Liraglutide | 1 | 0 | 1 |
| Exenatide | 0 | 1 | 3 |
| Donepezil | 0 | 1 | 2 |
| Qsymia | 0 | 0 | 1 |
Drug classes tested here GLP-1 receptor agonists 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Dec 2026Long-Term Longitudinal QoL in Patients Undergoing EEA · Ohio State University
- Dec 2026Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery · West China Hospital
- Dec 2026ImmunoPET Targeting Trophoblast Cell-surface Antigen 2 (Trop-2) in Craniopharyngioma Patients · Deling Li
- Mar 2027Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults · Sabine Mueller, MD, PhD
- Apr 2027FOG-001 in Locally Advanced or Metastatic Solid Tumors · Parabilis Medicines, Inc.
- Apr 2027MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma · Nationwide Children's Hospital
- Jul 2027Methionine PET/CT Studies In Patients With Cancer · St. Jude Children's Research Hospital
- Sep 2027Treatment of BRAF ( B-Rapidly Accelerated Fibrosarcoma) Mutated Papillary Craniopharyngioma · Eva Marie Erfurth, MD, PhD
Who these studies take
Of the 13 Craniopharyngioma studies recruiting now, 5 (38%) set no upper age limit and 7 (54%) stop at 75 or younger. 5 (38%) take children under 18. 1 (8%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (31%) | 4 (31%) |
| 18 | 12 (92%) | 11 (85%) |
| 30 | 12 (92%) | 11 (85%) |
| 40 | 9 (69%) | 8 (62%) |
| 50 | 9 (69%) | 8 (62%) |
| 65 | 9 (69%) | 8 (62%) |
| 75 | 8 (62%) | 7 (54%) |
| 85 | 5 (38%) | 4 (31%) |
Across all 76 studies, recruiting or not: 55% stop at 75 or younger and 39% at 65; 42% take children; 1% are for women only and 1% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 76. Browse all 76 → or search them.
- Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncologyRecruitingNCT046484621 country
- FOG-001 in Locally Advanced or Metastatic Solid TumorsRecruitingNCT05919264Phase 1/22 countries
- SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 YearsNot yet recruitingNCT07845994Phase 31 country
- A Comparative Study Evaluating the Impact of Intensive Dietary Care on Weight Change and Biological Parameters in Patients Who Underwent Surgery for Craniopharyngioma During the First Postoperative YearNot yet recruitingNCT07835165Not applicable
- AI-Assisted MRI Molecular Subtyping in Pediatric Brain TumorsNot yet recruitingNCT07703605
- Randomized Controlled Clinical Study on the Prophylactic Intraoperative Use of Desmopressin in Complex Sellar Region TumorsEnrolling by invitationNCT07712328Phase 41 country
- Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor SurgeryRecruitingNCT07316101Not applicable1 country
- Tovorafenib for Treatment of Craniopharyngioma in Children and Young AdultsRecruitingNCT05465174Phase 22 countries
- ACTEMRA® for the Treatment of Pediatric Adamantinomatous CraniopharyngiomaRecruitingNCT05233397Phase 23 countries
- MEKTOVI® for the Treatment of Pediatric Adamantinomatous CraniopharyngiomaRecruitingNCT05286788Phase 23 countries
- Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical TherapyEnrolling by invitationNCT036109061 country
- Food Preferences and CraniopharyngiomasNot yet recruitingNCT073015541 country
- Safety and Efficacy of Anlotinib in the Treatment of Recurrent CraniopharyngiomaRecruitingNCT06970145Phase 1/21 country
- ImmunoPET Targeting Trophoblast Cell-surface Antigen 2 (Trop-2) in Craniopharyngioma PatientsRecruitingNCT07177482Not applicable1 country
- The Impact of Endoscopic Endonasal Skull Base Surgery on OlfactionRecruitingNCT068744263 countries
- Craniopharyngioma and PregnanciesRecruitingNCT068017561 country
- Multicenter Registry for Patients With Childhood.Onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid CystsRecruitingNCT041582841 country
- Treatment of BRAF ( B-Rapidly Accelerated Fibrosarcoma) Mutated Papillary CraniopharyngiomaRecruitingNCT05525273Phase 21 country
- The Effect of GLP-1 Agonist in Patients With Hypothalamic Obesity: Prospective, Pilot StudyRecruitingNCT06217848Early Phase 11 country
- China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial AneurysmActive, not recruitingNCT078091781 country
- Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic ObesityActive, not recruitingNCT06299891Phase 21 country
- Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive CraniopharyngiomaActive, not recruitingNCT03224767Phase 21 country
- A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical ResectionActive, not recruitingNCT02792582Phase 21 country
- A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical ResectionActive, not recruitingNCT01419067Phase 21 country
- Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas SystemCompletedNCT04743310Phase 21 country
- Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain TumorsCompletedNCT03194906Phase 21 country
- Methionine PET/CT Studies In Patients With CancerActive, not recruitingNCT00840047Phase 21 country
- Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma TherapyCompletedNCT02860923Phase 31 country
- Long-Term Longitudinal QoL in Patients Undergoing EEAActive, not recruitingNCT040879021 country
- Tocilizumab in Children With ACPActive, not recruitingNCT03970226Early Phase 11 country
- Hypothalamic-Stratified Nursing Pathway for Pediatric CraniopharyngiomaCompletedNCT073426861 country
- Molecular-Guided Therapy for Childhood CancerCompletedNCT02162732Not applicable2 countries
- Management of Pediatric Craniopharyngioma by a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma)CompletedNCT02842723Phase 21 country
- Stereotactic Radiosurgery in Treating Patients With Brain TumorsCompletedNCT00019578Phase 11 country
- Intranasal Oxytocin in Hypothalamic ObesityCompletedNCT02849743Phase 21 country
- Antineoplaston Therapy in Treating Children With Brain TumorsCompletedNCT00003458Phase 21 country
- Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain TumorsCompletedNCT00369785Phase 31 country
- Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain TumorCompletedNCT00070161Phase 21 country
- Craniopharyngioma With Tumoral HemorrhageCompletedNCT04937335
- Neuromodulation for Hypothalamic ObesityWithdrawnNCT03708913Not applicable1 country
- Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain DisordersCompletedNCT002556711 country
- Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By SurgeryTerminatedNCT01964300Phase 21 country
- Prospective Study of Children and Adolescents With CraniopharyngiomaCompletedNCT01272622Not applicable1 country
- Effects of Exenatide on Hypothalamic ObesityCompletedNCT01061775Phase 1/21 country
- Photodynamic Therapy (PDT) For Recurrent High Grade GliomasTerminatedNCT01966809Phase 21 country
- Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma PatientsCompletedNCT033300801 country
- Photodynamic Therapy (PDT) for Recurrent Pediatric Brain TumorsCompletedNCT01682746Phase 11 country
- A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain TumorsCompletedNCT00784914Phase 11 country
- Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain TumorsCompletedNCT004997981 country
- Social Participation After Childhood CraniopharyngiomaCompletedNCT03139526