Cholestasis, Intrahepatic clinical trials
The registry lists 15 studies for Cholestasis, Intrahepatic across more than 10 countries. 3 are recruiting or about to start. 7 of them are mainly about Cholestasis, Intrahepatic (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-08. Counting its 4 narrower conditions too, such as Liver Cirrhosis, Biliary: 298 studies, 74 open.
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Who runs them
Children's Hospital of Fudan University (1) · Children's Hospital Medical Center, Cincinnati (1) · Epsom and St Helier University Hospitals NHS Trust (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Hospital General Universitario Gregorio Marañon (1) · Mirum Pharmaceuticals, Inc. (1) · Children's Hospital of Eastern Ontario (1) · GlaxoSmithKline (1)
What is being tested here
Drugs under test in Cholestasis, Intrahepatic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ursodeoxycholic Acid | 0 | 2 | 2 |
| Maralixibat | 0 | 0 | 1 |
| Linerixibat | 0 | 0 | 1 |
| S-Adenosylmethionine | 0 | 1 | 1 |
| Metformin | 0 | 1 | 1 |
| Phenylbutyric acid | 0 | 1 | 1 |
Who these studies take
Of the 2 Cholestasis, Intrahepatic studies recruiting now, 1 (50%) set no upper age limit and 1 (50%) stop at 75 or younger. 1 (50%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (50%) | 1 (50%) |
| 18 | 2 (100%) | 2 (100%) |
| 30 | 1 (50%) | 1 (50%) |
| 40 | 1 (50%) | 1 (50%) |
| 50 | 1 (50%) | 1 (50%) |
| 65 | 1 (50%) | 1 (50%) |
| 75 | 1 (50%) | 1 (50%) |
| 85 | 1 (50%) | 1 (50%) |
Across all 15 studies, recruiting or not: 73% stop at 75 or younger and 53% at 65; 60% take children; 27% are for women only and 0% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 15 of 15. search them.
- Pediatric Evaluation and Registry for Liver Cholestasis in CanadaRecruitingNCT074117161 country
- Impact of Intrahepatic Cholestasis of Pregnancy on Neonatal Respiratory OutcomesEnrolling by invitationNCT066799721 country
- Genotype-phenotype Relationship Between Cryptogenic Cholestasis and Familial Intrahepatic CholestasisRecruitingNCT067812421 country
- Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)WithdrawnNCT038905361 country
- Comparative Study of REMAXA®, Enteric-coated Tablets and REMAXOL®, Solution for Infusions, in Intrahepatic CholestasisCompletedNCT06183242Phase 2/31 country
- Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic CholestasisCompletedNCT02057718Phase 24 countries
- BSEP Function Rescue During Childhood Inhereditary Cholestatic DiseasesWithdrawnNCT04531878Phase 2/3
- Metformin in Intrahepatic Cholestasis of PregnancyStatus unknownNCT03056274Phase 2/3
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of PruritusCompletedNCT01899703Phase 21 country
- Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid EmulsionsTerminatedNCT02633384Phase 4
- Impact of Cyclic Prolonged Parenteral Nutrition in NeonatesCompletedNCT02692326Not applicable1 country
- Study With Heptral in Subjects With Liver Disease Due to Alcohol ConsumptionCompletedNCT02200029Phase 31 country
- Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.Status unknownNCT021921771 country
- Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of PregnancyCompletedNCT01576458Phase 31 country
- Induction of Labor in Intrahepatic Cholestasis of PregnancyCompletedNCT01381939