Cerebrospinal Fluid Leak clinical trials
The registry lists 41 studies for Cerebrospinal Fluid Leak across more than 10 countries. 9 are recruiting or about to start. 28 of them are mainly about Cerebrospinal Fluid Leak (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-15.
Get an email when these change. Save the Cerebrospinal Fluid Leak studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Medprin Regenerative Medical Technologies Co., Ltd. (3) · Integra LifeSciences Corporation (2) · Nurami Medical Ltd (2) · Polyganics BV (2) · University of Miami (2) · Tehran University of Medical Sciences (1) · Top Health S.A.P.I DE C.V. (1) · University Hospital Freiburg (1)
What is being tested here
Drugs under test in Cerebrospinal Fluid Leak studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Acetazolamide | 0 | 0 | 4 |
| Fibrin Tissue Adhesive | 0 | 1 | 2 |
| Lidocaine | 0 | 0 | 1 |
| Morphine | 0 | 0 | 1 |
| Fibrinogen | 0 | 1 | 1 |
| Thrombin | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery · Indiana University
- Feb 2027CraniSeal Post Approval Study · Pramand LLC
- Nov 2027Safety and Efficacy Evaluation of ArtiFix® Sealant Graft in Subjects Requiring Dural Repair Following Neurosurgery · Nurami Medical Ltd
Who these studies take
Of the 7 Cerebrospinal Fluid Leak studies recruiting now, 5 (71%) set no upper age limit and 1 (14%) stop at 75 or younger. 1 (14%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (29%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (14%) | 1 (14%) |
| 18 | 6 (86%) | 6 (86%) |
| 30 | 7 (100%) | 7 (100%) |
| 40 | 7 (100%) | 7 (100%) |
| 50 | 7 (100%) | 7 (100%) |
| 65 | 7 (100%) | 7 (100%) |
| 75 | 7 (100%) | 7 (100%) |
| 85 | 5 (71%) | 5 (71%) |
Across all 41 studies, recruiting or not: 27% stop at 75 or younger and 12% at 65; 10% take children; 5% are for women only and 0% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
- Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery.Oct 15, 2026NCT07876713
Studies
Recruiting first, then most recently updated. Showing 41 of 41. search them.
- Role of Novel RADA16 Hydrogel in Endoscopic Skull Base SurgeryRecruitingNCT05898074Not applicable1 country
- Immiseal™ Dural Sealant Post-Market Registry StudyRecruitingNCT076518261 country
- Conservative vs Interventional Management of Postsurgical CSF PseudomeningoceleRecruitingNCT07614399Not applicable1 country
- Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial TumorsRecruitingNCT074116901 country
- CraniSeal Post Approval StudyRecruitingNCT06406790Phase 41 country
- Safety and Efficacy Evaluation of ArtiFix® Sealant Graft in Subjects Requiring Dural Repair Following NeurosurgeryNot yet recruitingNCT07092267Not applicable
- The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)RecruitingNCT067117311 country
- Effect of Spinal Needle Type on Optic Nerve Sheath DiameterNot yet recruitingNCT06497634Not applicable1 country
- Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid LeakageRecruitingNCT06472505Not applicable1 country
- Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery.CompletedNCT07876713Phase 41 country
- Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in ObstetricsCompletedNCT03181464Phase 41 country
- A Trial of Absorbable Medical Adhesive for Prevention of CSF LeakCompletedNCT07768553Phase 31 country
- Dural Medical Adhesive for Watertight Sealing in Dural RepairCompletedNCT07754344Phase 31 country
- A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes. To Evaluate the Safety and Effectiveness of ArtiFascia® in Subjects Requiring Dural Repair.CompletedNCT04145544Not applicable5 countries
- Suturable DuraGen™ PMCF StudyCompletedNCT049238671 country
- Study to Evaluate the Effectivity and Safety of BIOSCAFF®H Compared to DuraGen®, in Patients Undergoing Dural RepairTerminatedNCT064198551 country
- Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial SurgeryCompletedNCT04086550Not applicable7 countries
- Lumbar Drainage in Subarachnoid HaemorrhageCompletedNCT00842049Phase 21 country
- Sonographic Monitoring of Weaning of Cerebrospinal Fluid DrainagesTerminatedNCT024087571 country
- Observational Pilot Study With TachoSil as a Ventricular SealantCompletedNCT057173351 country
- Influence of Drainage on EVD ICP-signalCompletedNCT031644341 country
- Post-market Assessment of Biodesign Dural Repair GraftsCompletedNCT040571573 countries
- Evaluation of Outcomes Related to Cerebrospinal Fluid Drain PlacementCompletedNCT045054231 country
- Acetazolamide for the Prevention of Post Operative CSF LeakWithdrawnNCT04351061Phase 21 country
- Incidence of Headache Following an Unintentional Dural PunctureCompletedNCT01977898Not applicable1 country
- Risk Factors for Postoperative Spinal Epidural Hematoma Following Posterior Thoracic Spinal Surgery in a Single InstituteCompletedNCT049614241 country
- A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for TreatmentCompletedNCT03276975Phase 21 country
- Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial SurgeryCompletedNCT03566602Not applicable2 countries
- The Efficacy and Safety of a Latest Dural SubstituteStatus unknownNCT04490629Not applicable1 country
- Perioperative CSF Leak Management - an Opinion StudyCompletedNCT041245231 country
- Acetazolamide to Prevent Post Operative CSF LeakWithdrawnNCT02902133Phase 2
- Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial SurgeryCompletedNCT02891070Phase 34 countries
- Evaluation of a Simulation Based Workshop in an Anesthesia Residency ProgramCompletedNCT03545984Not applicable
- The EVICEL® Neurosurgery Phase III StudyCompletedNCT02457546Phase 36 countries
- Cerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus SurgeryCompletedNCT023826921 country
- DuraSeal Exact Spine Sealant System Post-Approval StudyCompletedNCT014108641 country
- Performance and Safety of I-020805 in Prevention of Cerebrospinal Fluid (CSF) Leakage Following Elective CraniotomyCompletedNCT01295619Not applicable2 countries
- Mobilisation Algorithm After Incidental DurotomyStatus unknownNCT02927782Not applicable1 country
- CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar TapWithdrawnNCT01932255
- Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound DehiscenceStatus unknownNCT01867268Phase 21 country
- TASALL - TachoSil® Against Liquor LeakCompletedNCT01355627Phase 311 countries