Clear-cell metastatic renal cell carcinoma clinical trials
The registry lists 70 studies for Clear-cell metastatic renal cell carcinoma across more than 10 countries. 31 are recruiting or about to start. 57 of them are mainly about Clear-cell metastatic renal cell carcinoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Who runs them
City of Hope Medical Center (4) · Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie (3) · M.D. Anderson Cancer Center (3) · Vanderbilt-Ingram Cancer Center (2) · University of Texas Southwestern Medical Center (2) · Sunnybrook Health Sciences Centre (2) · Pfizer (2) · Celldex Therapeutics (2)
What is being tested here
Drugs under test in Clear-cell metastatic renal cell carcinoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 5 open · Immune checkpoint inhibitors 5 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors · Fox Chase Cancer Center
- Dec 2026AB-2100, an Integrated Circuit T Cell Therapy in Patients With Recurrent Clear-cell Renal Cell Carcinoma (ccRCC) · Arsenal Biosciences, Inc.
- Dec 2026DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers · M.D. Anderson Cancer Center
- Jan 2027Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma · Neomorph, Inc
- Jan 2027Imaging Study in Metastatic Clear Cell RCC. · RayzeBio, Inc.
- Jan 2027CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer · City of Hope Medical Center
- Apr 2027Dual-target CD70/CAIX CAR-NK Cells for Advanced Clear Cell Renal Cell Carcinoma · Beijing Biotech
- May 2027Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform · Mayo Clinic
- Jun 2027Safety and Efficacy of Yiwoxidan Anti (AK112) Monotherapy in Patients With Metastatic Renal Clear Cell Carcinoma Who Are Intolerant to TKI Treatment: a Prospective, Single Arm, Phase II Clinical Study · Sun Yat-sen University
- Sep 2027Imaging of Solid Tumors Using 18F-TRX · Rahul Aggarwal
Who these studies take
Of the 25 Clear-cell metastatic renal cell carcinoma studies recruiting now, 22 (88%) set no upper age limit and 1 (4%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 25 (100%) | 25 (100%) |
| 30 | 25 (100%) | 25 (100%) |
| 40 | 25 (100%) | 25 (100%) |
| 50 | 25 (100%) | 25 (100%) |
| 65 | 25 (100%) | 25 (100%) |
| 75 | 25 (100%) | 25 (100%) |
| 85 | 24 (96%) | 24 (96%) |
Across all 70 studies, recruiting or not: 7% stop at 75 or younger and 0% at 65; 1% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)WithdrawnOct 22, 2026NCT07179770
Studies
Recruiting first, then most recently updated. Showing 50 of 70. Browse all 70 → or search them.
- Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell CarcinomaRecruitingNCT07300241Phase 11 country
- Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell CarcinomaRecruitingNCT07011719Phase 317 countries
- Imaging Study in Metastatic Clear Cell RCC.RecruitingNCT07671417Early Phase 13 countries
- Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE TrialRecruitingNCT04510597Phase 31 country
- Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell CancerRecruitingNCT07227415Phase 1/26 countries
- Casdatifan for the Treatment of Refractory Metastatic Clear Cell Renal Cell CarcinomaRecruitingNCT07748988Phase 11 country
- Phase I Study Evaluating 161Tb-PSMA Therapy in Adult Patients With Metastatic Clear Cell Renal Cell CarcinomaNot yet recruitingNCT07828249Phase 11 country
- Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO TrialNot yet recruitingNCT07576725Phase 21 country
- TACTIC-RCC: Toripalimab Plus Axitinib Induction With Selective Deferred Cytoreductive Nephrectomy in TLS-Positive Advanced Clear Cell Renal Cell CarcinomaNot yet recruitingNCT07776717Phase 2
- Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC StudyRecruitingNCT05361720Phase 21 country
- A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)RecruitingNCT07195682Phase 15 countries
- CD70-Targeted Immuno-PET/CT-Directed Free of Therapy Used for mccRCC Patients With IMDC Favorable or Intermediate RiskRecruitingNCT07615348Phase 21 country
- Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON TrialRecruitingNCT06866262Phase 1/21 country
- Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine TumorsRecruitingNCT05263050Phase 21 country
- Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone MetastasesRecruitingNCT07043608Phase 21 country
- Imaging of Solid Tumors Using 18F-TRXRecruitingNCT06942104Phase 11 country
- Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell CancerRecruitingNCT07128680Phase 11 country
- The Safety and Efficacy of Allogeneic CD70 CAR-T Therapy in Unresectable or Metastatic Clear Cell Renal Cell CarcinomaRecruitingNCT07645690Early Phase 11 country
- Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney CancerRecruitingNCT07383441Phase 31 country
- VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell CarcinomaRecruitingNCT07510334Phase 21 country
- Radiopharmaceutical Treatment of Advanced Kidney CancerRecruitingNCT06783348Phase 21 country
- Zanzalintinib and MO-03 for the Treatment of Metastatic Renal Cell Cancer After Progression on ImmunotherapyNot yet recruitingNCT07578025Phase 21 country
- Dual-target CD70/CAIX CAR-NK Cells for Advanced Clear Cell Renal Cell CarcinomaRecruitingNCT07551349Phase 1/21 country
- Safety and Efficacy of Yiwoxidan Anti (AK112) Monotherapy in Patients With Metastatic Renal Clear Cell Carcinoma Who Are Intolerant to TKI Treatment: a Prospective, Single Arm, Phase II Clinical StudyEnrolling by invitationNCT07488572Phase 21 country
- Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic PlatformRecruitingNCT063496421 country
- [18F] PSMA-1007 PET/CT in Metastatic Clear Cell Renal Cell CarcinomaRecruitingNCT06428708Early Phase 11 country
- CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney CancerRecruitingNCT06399419Phase 11 country
- Pembrolizumab Plus Radiotherapy for Advanced Renal CancerRecruitingNCT05567588Phase 21 country
- 68Ga-NY104 PET/CT in Patients With Metastatic Clear Cell Renal Cell CarcinomaRecruitingNCT05879471Phase 21 country
- The Role of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma in Immuno-oncology Era: SEVURO-CN TrialRecruitingNCT05753839Not applicable1 country
- Clinical Study to Evaluate Safety and Dosing of CA9hu-1 in Patients With Advanced Solid TumoursNot yet recruitingNCT05698238Phase 1
- Seleno-L Methionine (SLM)-Axitinib-PembrolizumabCompletedNCT05363631Phase 1/21 country
- AB-2100, an Integrated Circuit T Cell Therapy in Patients With Recurrent Clear-cell Renal Cell Carcinoma (ccRCC)Active, not recruitingNCT06245915Phase 1/21 country
- Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)WithdrawnNCT07179770Phase 11 country
- RP2 and Tivozanib for the Treatment of Metastatic Renal Cell Cancer After Progression on ImmunotherapyWithdrawnNCT07218692Phase 21 country
- Lenvatinib With Everolimus Versus Cabozantinib for Second-Line or Third-Line Treatment of Metastatic Renal Cell CancerActive, not recruitingNCT05012371Phase 21 country
- Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell CarcinomaActive, not recruitingNCT04696731Phase 11 country
- Validation of a Predictive Nomogram of Response or Resistance to Targeted Therapies in Metastatic Clear Cell Renal Cell CarcinomaCompletedNCT028487681 country
- DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell CancersActive, not recruitingNCT04388852Phase 11 country
- Phase I/II Study Evaluating PSMA Targeted Radionuclide Therapy in Adult Patients With Metastatic Clear Cell Renal CancerCompletedNCT06059014Phase 1/21 country
- Sitravatinib and Nivolumab for the Treatment of Metastatic or Advanced Clear Cell Renal Cell CancerTerminatedNCT04904302Phase 21 country
- CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney CancerActive, not recruitingNCT05122546Phase 11 country
- Aldesleukin and Pembrolizumab in Treating Patients With Advanced or Metastatic Kidney CancerTerminatedNCT03260504Phase 11 country
- Pembrolizumab With or Without Axitinib for Clear Cell Kidney Cancer in Patients Undergoing SurgeryTerminatedNCT04370509Phase 21 country
- PSMA Therapy and Immunotherapy in Kidney CancerWithdrawnNCT06361810Phase 1/2
- Pharmacokinetics, Biodistribution, Radiation Dose and Safety Study of 68Ga-NYM005 in PatientsCompletedNCT06389682Phase 1/21 country
- A Phase II Study of Axitinib in Patients With Metastatic Renal Cell Cancer Unsuitable for NephrectomyCompletedNCT01693822Phase 21 country
- A Study to go Back Into Records and Observe How People With Metastatic Renal Cell Carcinoma (mRCC) Who Received a Medicine Called Sunitinib Responded to This Medicine.CompletedNCT057451421 country
- Combining Radiosurgery and Nivolumab in the Treatment of Brain MetastasesCompletedNCT02978404Phase 21 country
- A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)CompletedNCT03679767Phase 28 countries