Blastic Plasmacytoid Dendritic Cell Neoplasm clinical trials
The registry lists 45 studies for Blastic Plasmacytoid Dendritic Cell Neoplasm across more than 10 countries. 15 are recruiting or about to start. 17 of them are mainly about Blastic Plasmacytoid Dendritic Cell Neoplasm (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-26.
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Fred Hutchinson Cancer Center (8) · M.D. Anderson Cancer Center (4) · City of Hope Medical Center (3) · Stemline Therapeutics, Inc. (3) · Mayo Clinic (3) · Mustang Bio (2) · Centre Hospitalier Universitaire de Besancon (2) · Dana-Farber Cancer Institute (2)
What is being tested here
Drugs under test in Blastic Plasmacytoid Dendritic Cell Neoplasm studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Antimetabolites 4 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Nov 2026A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies · MacroGenics
- Dec 2026Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm · M.D. Anderson Cancer Center
- Mar 2027Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies · Beijing Biotech
- May 2027A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy · Stemline Therapeutics, Inc.
- Jun 2027Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/Refractory AML or BPDCN · Chongqing Precision Biotech Co., Ltd
- Jul 2027Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm · City of Hope Medical Center
- Aug 2027Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant · Fred Hutchinson Cancer Center
- Oct 2027HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant · Fred Hutchinson Cancer Center
Who these studies take
Of the 14 Blastic Plasmacytoid Dendritic Cell Neoplasm studies recruiting now, 7 (50%) set no upper age limit and 6 (43%) stop at 75 or younger. 6 (43%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (43%) | 6 (43%) |
| 18 | 14 (100%) | 14 (100%) |
| 30 | 12 (86%) | 12 (86%) |
| 40 | 12 (86%) | 12 (86%) |
| 50 | 12 (86%) | 12 (86%) |
| 65 | 12 (86%) | 12 (86%) |
| 75 | 11 (79%) | 11 (79%) |
| 85 | 7 (50%) | 7 (50%) |
Across all 45 studies, recruiting or not: 31% stop at 75 or younger and 13% at 65; 40% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
- CARCIK CD123/33 for Refractory/Relapsed AML and BPDCN in Children and AdultsOct 16, 2026NCT07877610
Studies
Recruiting first, then most recently updated. Showing 45 of 45. search them.
- Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic DiseasesRecruitingNCT06013423Phase 21 country
- CARCIK CD123/33 for Refractory/Relapsed AML and BPDCN in Children and AdultsRecruitingNCT07877610Phase 1/21 country
- A Non-interventional Study of Participants With BPDCN Treated With ChemotherapyRecruitingNCT0778518011 countries
- Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic SyndromeNot yet recruitingNCT07819396Phase 21 country
- Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell NeoplasmRecruitingNCT04216524Phase 21 country
- Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/Refractory AML or BPDCNRecruitingNCT06690827Phase 11 country
- A Registry-study of ELZONRIS in Participants With BPDCNRecruitingNCT077851544 countries
- Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm PatientsRecruitingNCT07007052Phase 21 country
- SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)RecruitingNCT03113643Phase 11 country
- Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International RegistryRecruitingNCT0543097115 countries
- CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)RecruitingNCT04318678Phase 11 country
- HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell TransplantRecruitingNCT03326921Phase 11 country
- Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic MalignanciesRecruitingNCT07523555Phase 1/21 country
- Q702 for the Treatment of Patients With Hematologic MalignanciesRecruitingNCT06712810Phase 11 country
- Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic MalignanciesRecruitingNCT05476770Phase 12 countries
- Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell TransplantActive, not recruitingNCT03779854Phase 21 country
- CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I TrialActive, not recruitingNCT06765876Early Phase 11 country
- Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCNActive, not recruitingNCT03386513Phase 1/26 countries
- Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell NeoplasmActive, not recruitingNCT02159495Phase 11 country
- Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesActive, not recruitingNCT04013685Phase 11 country
- Safety and Efficacy of CD123-targeted CAR-NK for Relapsed/Refractory Acute Myeloid Leukemia or Blastic Plasmacytoid Dendritic Cell NeoplasmCompletedNCT06006403Phase 1/21 country
- A Study of MGD024 in Patients With Relapsed or Refractory Hematologic MalignanciesActive, not recruitingNCT05362773Phase 11 country
- Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHDCompletedNCT02220985Phase 21 country
- Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell TransplantationTerminatedNCT03246906Phase 21 country
- Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic SyndromeTerminatedNCT03404193Phase 21 country
- SENTI-202: Off-the-shelf Logic Gated CAR NK Cell Therapy in Adults With CD33 and/or FLT3 Blood Cancers Including AML/MDSActive, not recruitingNCT06325748Phase 12 countries
- Study of Venetoclax, a BCL2 Antagonist, for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)CompletedNCT03485547Phase 11 country
- Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological MalignanciesCompletedNCT04681105Phase 11 country
- Tagraxofusp in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid LeukemiaCompletedNCT02113982Phase 1/21 country
- Tagraxofusp in Treating Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm After Stem Cell TransplantTerminatedNCT04317781Phase 21 country
- Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.TerminatedNCT056457441 country
- Trial to Evaluate the Safety and Efficacy of MB-102 in Patients With BPDCN.TerminatedNCT04109482Phase 1/21 country
- Combination Chemotherapy in Patients With Newly Diagnosed BPDCNActive, not recruitingNCT03599960Phase 21 country
- PH 1 Study to Evaluate Safety and Tolerability of XmAb14045 in Patients With CD123-expressing Hematologic MalignanciesCompletedNCT02730312Phase 11 country
- Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood CancerWithdrawnNCT03739606Phase 2
- Blastic Plasmacytoid Dendritic Cell Neoplasm in Korean Population.CompletedNCT039749711 country
- Rivogenlecleucel Donor Lymphocyte Immunotherapy in Treating Patients With Recurrent Blood Cancers After Stem Cell TransplantWithdrawnNCT03807063Phase 11 country
- Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell LymphomaTerminatedNCT03075553Phase 21 country
- Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic MalignanciesCompletedNCT00014235Not applicable3 countries
- Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin LymphomaCompletedNCT02652715Not applicable1 country
- Study to Evaluate the Safety and Clinical Activity of UCART123 in Patients With BPDCNTerminatedNCT03203369Phase 11 country
- DT388IL3 Fusion Protein in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic SyndromesCompletedNCT00397579Phase 1/21 country
- An Open-label Phase II Study of Lorvotuzumab MertansineCompletedNCT02420873Phase 21 country
- Descriptive Study of the Efficacy of Treatments for Blastic Dendritic Cell Neoplasm (BPDCN)CompletedNCT02859623
- MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or LeukemiaCompletedNCT01231919Phase 12 countries