An observational study in ATTR Amyloidosis Wild Type, ATTR Gene Mutation and Carpal Tunnel Syndrome, sponsored by Helse Møre og Romsdal HF. Recruiting at 1 site in Norway. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-08-12.
Sponsored by Helse Møre og Romsdal HF · Observational
Patients operated for carpal tunnel syndrome (CTS) at Ålesund Hospital (200 patients) will have a biopsy to diagnose ATTR amyloidosis. Patients with positive biopsy will be examined to decide wether they have cardiac amyloidosis. All patients with positive biopsy will be followed closely for 10 years wit echocardiography an clinically.
Biopsy proven ATTR (v/wt) amyloidosis inpatients operated with CTS will undergo standard guidelines recommended examinations as 99mTcDPD SPECT CT, echocardiography, ECG, Holter, genetic testing (v/wt), and lab testing, and CMRI as indicated. Exclusion of light chain disease will be done.
All patients will be followed at least yearly as indicated by guidelines (ESC), and patients with development of cardiac amyloidosis will get standard treatment in accordance with guidelines and as approved by the Norwegian government. All patients will be followed for 10 years.
587 studies on the registry are indexed under Carpal Tunnel Syndrome; 134 are open to participants now.
This study's planned enrollment of 180 is above the median of 94 across 130 observational studies indexed under Carpal Tunnel Syndrome.
Browse Carpal Tunnel Syndrome studies →Helse Møre og Romsdal HF is the lead sponsor of 24 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Maximum 200 patients operated at Ålesund Hospital for CTS
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Frequency of ATTR in CTS
Biopsy proven ATTR
Time frame: 2 years
Cardiac involvement in patients with biopsy proven ATTR
Scintigraphic and echocardiographic cardiac involvement possibly cMRI
Time frame: 10 years
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Helse Møre og Romsdal HF