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RecruitingNCT07583823Updated May 13, 2026

Elevated Rate Pacing of Cardiac Amyloidosis

An interventional study of Pacemaker Rate in Cardiac Amyloidosis and Pacemaker, sponsored by University of Minnesota. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-13.

Sponsored by University of Minnesota · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Oct 2025, registered May 2026).
  • Started Oct 2025; still recruiting 11 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to better quantify the improvements in heart failure symptoms and exercise tolerance before and after the heart rate elevation in a cohort of 10 cardiac amyloidosis patients with preexisting pacemakers.

02

Conditions studied

  • Cardiac Amyloidosis
  • Pacemaker
03

In context

Amyloid Neuropathies, Familial

122 studies on the registry are indexed under Amyloid Neuropathies, Familial; 71 are open to participants now.

This study's planned enrollment of 10 is below the median of 60 across 61 interventional studies indexed under Amyloid Neuropathies, Familial.

Browse Amyloid Neuropathies, Familial studies →

Lead sponsor

University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.

Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Adults 18 and older
  • Diagnosis of cardiac amyloidosis as indicated by the criteria set forth in guidelines such as in Kittleson et al: "2023 ACC Expert Consensus Decision Pathway on Comprehensive Multidisciplinary Care for the Patient With Cardiac Amyloidosis: A Report of the American College of Cardiology Solution Set Oversight Committee
  • Implanted Cardiac Pacemaker (+/- Defibrillator)
  • Pacemaker mode of AAI or DDD if in sinus rhythm, VVI acceptable if permanent atrial fibrillation
  • Non-dilated left ventricle by echocardiography
  • Ability to provide written consent
  • English Speaking

Exclusion criteria

Exclusion Criteria:

  • Paced QRS duration of >150 ms (indicator for pacing mediated dyssynchrony)
  • Dilated left ventricle
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (estimated)

Study arms

  • Experimental
    Elevated Pacemaker Rate

    CA clinic patients with pacemakers will receive a personalized pacing protocol individual to their height and left ventricular ejection fraction.

    Other: Pacemaker Rate

Interventions

  • OtherPacemaker Rate

    CA clinic patients with pacemakers will receive a personalized pacing protocol individual to their height and left ventricular ejection fraction.

06

What researchers measure

Primary outcomes

  1. Kansas City Cardiomyopathy Questionnaire Score

    75-100 representing good to excellent health, and 0-24 representing very poor to poor health

    Time frame: Month 4

  2. Composite of any cardiovascular event

    admission or urgent visit for heart failure and atrial fibrillation, myocardial infarction or stroke

    Time frame: Month 4

07

Study locations

1 of 1 sites recruiting
  • University of Minnesota
    Minneapolis, Minnesota 55455, United States
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07583823
Lead sponsor
University of Minnesota
Responsible party
Sponsor
First posted
May 13, 2026
Start date
Oct 10, 2025
Primary completion
Oct 10, 2026 (estimated)
Completion
Oct 10, 2026 (estimated)
Last update
May 13, 2026

Study contacts

Meghan Muscala
Contact
payne324@umn.edu
612-626-5863
Valmiki Maharaj
principal investigator · University of Minnesota

Oversight

FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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