An interventional study of Aerobic Exercise and Diaphragmatic Breathing in Nocturnal Enuresis, Pediatric Obesity and Overweight, sponsored by Hungarian University of Sports Science. Active, not recruiting at 1 site in Egypt. Open to participants aged 6 Years to 12 Years. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Hungarian University of Sports Science · Not applicable, Interventional, and Treatment
Among 22 studies in Nocturnal Enuresis with a site in Egypt — 5 open to participants now, 7 under way, 2 of them phase 3. Nocturnal Enuresis · Egypt.
Among the 22 studies in Nocturnal Enuresis with a site in Egypt, this one is the 16th largest by enrollment of the 18 interventional ones that give a count, is one of 2 that started in 2026, is one of 13 with no phase, and was the 22nd registered.
105 studies on the registry are indexed under Nocturnal Enuresis; 22 are open to participants now.
Browse Nocturnal Enuresis studies →5 of the 22 studies in Nocturnal Enuresis with a site in Egypt are open now. Recruiting first, the newest first:
Al-Azhar University · Sites in Egypt
Ages 6–14
Mansoura University · Sites in Egypt
Ages 6–18
Al-Azhar University · Sites in Egypt
Ages 7–14
Benha University · Sites in Egypt
Ages 5–15
Cairo University · Sites in Egypt
Ages 10–18 · Women only
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 14 Nocturnal Enuresis studies recruiting now, 5 (36%) set no upper age limit and 9 (64%) stop at 75 or younger; 8 take children under 18; 2 take healthy volunteers.
This study: 6 Years to 12 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
22 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 2 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 51 is below the median of 66 across 77 interventional studies indexed under Nocturnal Enuresis.
Median enrollment 95 across the 18 interventional studies, 190 across the 4 observational. Of the 10 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 22 has an industry lead sponsor. The 10 most frequent:
Hungarian University of Sports Science is the lead sponsor of 6 studies on the registry; none are open to participants now.
Hungarian University of Sports Science has 2 studies filed under Nocturnal Enuresis — fewer than ten, so there is no comparison to draw.
2 of the studies in Nocturnal Enuresis with a site in Egypt that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07930351Hungarian University of Sports ScienceAerobic Exercise Added to Diaphragmatic Breathing for Nocturnal Enuresis in Overweight and Obese Children | 2027-01-25 |
| NCT07776977Al-Azhar UniversityBedtime Device Restriction and Desmopressin in PMNE. | 2027-05 |
Add all 2 to your calendar (.ics) → With an account.
Among the 22 studies in Nocturnal Enuresis with a site in Egypt, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study tests whether adding aerobic exercise to diaphragmatic breathing helps overweight and obese children with primary nocturnal enuresis (bedwetting) more than diaphragmatic breathing alone. Children aged 6 to 12 years who wet the bed at least 3 times a week are randomly assigned to one of three groups: aerobic exercise plus diaphragmatic breathing, diaphragmatic breathing alone, or a waiting-list control group. The program lasts 12 weeks. The main outcomes are the number of bedwetting episodes per week and sleep quality. Body mass index and quality of life are also compared.
Nocturnal enuresis is involuntary nighttime wetting in children aged 5 years or older. It can lower self-esteem, disturb sleep and place strain on the family. Overweight and obese children have higher rates of nocturnal enuresis and more severe symptoms, and behavioral treatment works less well for them. Raised intra-abdominal pressure, disturbed sleep and autonomic dysfunction have been proposed as reasons for this link.
Diaphragmatic breathing may reduce pelvic floor muscle tone, improve abdominal and pelvic floor coordination and balance the autonomic nervous system. Aerobic exercise may improve body composition, sleep and autonomic regulation. Their combined effect in this population has not been tested in a randomized controlled trial.
This is a three-arm, parallel-group randomized controlled trial at the pediatric physiotherapy outpatient clinic of the Faculty of Physical Therapy, Kafrelsheikh University, Egypt. Participants are recruited through advertisement in Kafr El-Sheikh governorate. Parents or guardians give written informed consent. Children are asked to stop using enuresis alarms during the study.
Group 1 receives aerobic exercise and diaphragmatic breathing. Group 2 receives diaphragmatic breathing. Group 3 is a waiting-list control group. The intervention lasts 12 weeks. Enuresis frequency is recorded by parents in an enuresis diary. Sleep quality is measured with the second part of the Child and Adolescent Sleep Checklist (CASC), given in Arabic. Quality of life is measured with the Pediatric Incontinence Questionnaire (PinQ). Body mass index is calculated from measured weight and height.
It is hypothesized that the combined intervention will give greater improvements in enuresis frequency, sleep quality, body mass index and quality of life than diaphragmatic breathing alone.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Children receive the aerobic exercise program and diaphragmatic breathing exercises for 12 weeks.
Behavioral: Aerobic Exercise · Behavioral: Diaphragmatic Breathing
Children receive diaphragmatic breathing exercises alone for 12 weeks.
Behavioral: Diaphragmatic Breathing
Children keep their normal daily routine. They are asked to stop enuresis alarms during the assessment period and not to drink water or other liquids for two hours before sleep.
Treadmill walking, running, cycling, and jumping and rhythmic activities at moderate intensity (60 to 70% of maximum heart rate), with 5 minutes of warm-up and 5 minutes of cool-down. 3 sessions per week, 45 to 60 minutes per session, for 12 weeks.
A therapist teaches the exercises to children and parents using demonstration games and video clips. Exercises are done lying and sitting, every morning after getting up and every night before sleep, for 12 weeks. In balloon breathing the child lies on the back with knees bent, one hand on the belly and one on the chest, breathes in through the nose so the belly rises, and breathes out slowly through the mouth.
Also known as: Balloon breathing
Frequency of nocturnal enuresis episodes per week
Number of nocturnal enuresis episodes per week, recorded by parents in an enuresis diary. Fewer episodes is a better outcome.
Time frame: Baseline and 12 weeks
Sleep quality measured with the Child and Adolescent Sleep Checklist (CASC) total score
Second part of the CASC, given in Arabic: 24 items scored 0 to 3 across four domains (bedtime issues, sleep breathing and unsteady sleep, parasomnia and sleep movement, daytime issues). Total score range 0 to 72. A higher score means worse sleep, and a score above 18 suggests a sleep problem.
Time frame: Baseline and 12 weeks
Body mass index (BMI)
Weight in kilograms divided by height in meters squared (kg/m\^2).
Time frame: Baseline and 12 weeks
Quality of life measured with the Pediatric Incontinence Questionnaire (PinQ) total score
20 items scored 0 to 4 across five subscales. Total score range 0 to 80. A higher score means lower quality of life.
Time frame: Baseline and 12 weeks
Plan to share: Yes
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Analytic code
No publications or documents are linked to this record.
Started Nov 2026 (actual). Primary completion is estimated for Jan 2027, 2 months after the start.
Of 41 interventional studies with no phase under Nocturnal Enuresis, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 49. This study's planned 2 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Hungarian University of Sports Science