An interventional study of Dietary Salt Restriction and Omega Supplementation in Nocturnal Enuresis in Children and Primary Nocturnal Enuresis, sponsored by Cairo University. Not yet recruiting. Open to participants aged 5 Years to 12 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
To examine the possible reduction in dietary salt intake on the outcomes of nocturnal enuresis
Primary nocturnal enuresis is the involuntary discharge of urine at night by children old enough to be expected to have bladder control. Children should not be labelled enuretic unless regular (more than twice per week) wetting persists beyond the age of five years. Primary nocturnal enuresis is more common in boys. Bedwetting is found in 10% to 15% of five-year-old children and 6% to 8% of eight-year-old children, and it declines to 1% to 2% by 15 years of age.
Although overactive bladder is commonly associated with enuresis, the clinical relationship between these two conditions remains to be clarified. It was previously reported that reducing the salt intake improved nocturia and nocturnal polyuria. Consequently, we have focused on the dietary modifications that may improve urinary disorders.
Omega-3 fatty acids may influence primary nocturnal enuresis by regulating prostaglandin E2, nitric oxide synthesis, and brain signaling [9]. There is evidence that omega-3 is a potent inhibitor of prostaglandin E2 synthesis; omega-3 fatty acids are a potent inhibitor of prostaglandin E2 synthesis. The present evidence suggests that the collecting duct is the site at which prostaglandins act to determine the corticomedullary solute gradient. leading to increased sodium excretion.
Cairo University is the lead sponsor of 4,909 studies on the registry; 1,445 are open to participants now.
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Exclusion Criteria:
Participants with primary nocturnal enuresis and high dietary sodium intake will receive dietary counseling to reduce sodium intake, including education on hidden sodium sources and salt alternatives.
Behavioral: Dietary Salt Restriction
Participants who fail to restrict their sodium intake will receive omega supplementation at a dose of 1000 mg per day for 3 months. The study will reassess outcomes after omega supplementation and compare them with pre-intervention measurements.
Dietary Supplement: Omega Supplementation
Participants with high dietary sodium intake will receive dietary counseling to reduce salt intake. The intervention includes a nutritional brochure, health education every four weeks, avoidance of hidden sources of sodium such as junk foods, and guidance on alternatives to salt such as lemon and vinegar.
Participants who fail to restrict their sodium intake will receive omega supplementation at a dose of 1000 mg per day for 3 months. Outcomes will be assessed again after omega supplementation and compared with pre-intervention measurements.
Estimated 24-Hour Urinary Sodium Excretion
Estimated 24-hour urinary sodium excretion will be assessed using spot urine sodium and creatinine concentrations and a validated formula adjusted for age, body weight, and height.
Time frame: At baseline and at the end of the salt-restriction intervention
Number of Bed-Wetting Episodes per Week
The number of nocturnal bed-wetting episodes per week will be assessed using a urinary chart completed for one week at baseline and at the end of the study.
Time frame: At baseline and at the end of the salt-restriction intervention
Effect of Omega Supplementation on Estimated 24-Hour Urinary Sodium Excretion
Estimated 24-hour urinary sodium excretion will be assessed before and after omega supplementation using spot urinary sodium and creatinine concentrations and the specified estimation formula.
Time frame: At the start of omega supplementation and after 3 months of omega supplementation
Effect of Omega Supplementation on Number of Bed-Wetting Episodes per Week
The number of nocturnal bed-wetting episodes per week will be assessed before and after omega supplementation using a one-week urinary chart.
Time frame: At the start of omega supplementation and after 3 months of omega supplementation
Comparison of Salt Restriction and Omega Supplementation on Bed-Wetting Frequency and Urinary Sodium Excretion
The effects of salt restriction and omega supplementation will be compared regarding the frequency of bed-wetting and estimated 24-hour urinary sodium excretion.
Time frame: At the end of the salt-restriction intervention and after 3 months of omega supplementation
No study locations are listed for this record.
Plan to share: Undecided
Start is estimated for Dec 2026; primary completion for Jun 2027, 6 months later.
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