An interventional study of PRT (Pain Reprocessing Therapy) in Chronic Pain, sponsored by Ottawa Hospital Research Institute. Recruiting at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Ottawa Hospital Research Institute · Not applicable, Interventional, and Treatment
The goal of this study is to find out if a one-time session of Pain Reprocessing Therapy (PRT) intervention improves participant's mood and pain. Participants in this 4 hours session will be 40 patients who've been referred to the The Ottawa Hospital Pain Clinic (TOHPC) for chronic pain.
The main questions of this study are:
Participants in this study will:
3,227 studies on the registry are indexed under Chronic Pain; 729 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 2,388 interventional studies indexed under Chronic Pain.
Browse Chronic Pain studies →Ottawa Hospital Research Institute is the lead sponsor of 547 studies on the registry; 99 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Self-reported 1-week average pain intensity score between 4/10 and 9/10 on the Brief Pain Inventory (BPI)12 at screening.
o Note: Individuals scoring less than 4/10 or more than 9/10 will be directed to other pain clinic workshops and available resources (e.g., Power Over Pain)
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: PRT (Pain Reprocessing Therapy)
The intervention involves a single 4-hour PRT in-person group session (up to 20 patients per group) at The Ottawa Hospital Pain Clinic, delivered by a PRT certified clinician. The intervention is a brief mindfulness exercise (mindfulness of breath, energy, emotions, thoughts, sensations), followed by 90 minutes of didactic content focused on pain science education and foundation of pain reprocessing therapy. This includes interactive discussions, self-reflection, and skills building. This is followed by a brief exercise called predictive coding where participants are invited to draw a picture representing their pain. The remainder of the session includes gentle movement, somatic tracking, and practices to increase positive affect induction- specifically leaning into positive or neutral sensations and establishing short-term safety behaviours.
Clinical Effectiveness: Brief Pain Inventory (BPI) Pain Intensity and Pain Interference
Clinical effectiveness outcome measurement tools include Brief Pain Inventory (BPI): Participants will localize their pain through a drop down menu, in which they will select the applicable body part(s) where they experience pain. The BPI Pain Intensity and Pain Interference scales will then be administered. The pain intensity subscale includes 4 pain intensity ratings using an 11-point numerical rating scale (0-10) on current pain, average pain, worst pain during the last 7 days and least pain during the last 24 hours. The pain interference subscale includes 7 interference items that ask the patient to respond using an 11-point numerical rating scale (0-10). These items include the effect on general activity, mood, walking ability, normal work (including housework), relations with other people, sleep, and enjoyment of life.
Time frame: Baseline, 1 week post-intervention, 1 month follow up.
Interview
A random selection of participants will be interviewed regarding their PRT experience.
Time frame: Interviews will be conducted within 6 months of participating in the PRT session.
Clinical Effectiveness: Pain Self-Efficacy Questionnaire (PSEQ-10)
Clinical effectiveness outcome measurement tools include Pain Self-Efficacy Questionnaire (PSEQ-10): The PSEQ-10 is a validated 10-item tool for assessing the patient's pain self-efficacy or belief in one's capability to perform activities even when undergoing pain. The 10 items ask the patient to rate their confidence in doing activities on a 7-point numerical rating scale (0-6), with higher scores indicating greater confidence.
Time frame: Baseline, 1 week post-intervention, 1 month follow up.
Clinical Effectiveness: Patients' Global Impression of Change (PGI-C) Scale
Clinical effectiveness outcome measurement tools include Patients' Global Impression of Change (PGI-C) Scale: The PGI-C is a validated single- item self-report measure used to assess a patient's perceived change in overall status following a treatment or intervention. Patients select one of 7 options to describe their experience, ranging from "very much worse" to "very much improved." The PGI-C is widely used in chronic pain research and has demonstrated sensitivity to clinically meaningful change across a range of pain populations.
Time frame: 1 week post-intervention, 1 month follow up.
Clinical Effectiveness: Positive and Negative Affect Scale (PANAS)
Clinical effectiveness outcome measurement tools include Positive and Negative Affect Scale (PANAS) PANAS is a validated 20-item self-report measure assessing two distinct dimensions of mood: positive affect and negative affect. Participants rate the extent to which they have experienced each emotion using a 5-point Likert scale (1 = very slightly or not at all, 5 = extremely), with higher positive affect scores and lower negative affect scores reflecting better emotional well-being. The PANAS has demonstrated strong reliability and validity across clinical populations, including individuals with chronic pain.
Time frame: Day of Intervention, 1 week post-intervention, 1 month follow up.
Feasibility of recruitment
• Rates of participant eligibility and consenting will be tracked o The single session PRT model will be considered feasible if we can recruit our target sample size of 40 participants over a 6-month period.
Time frame: Baseline
Rate of participant accrual/completion
• Rates of participant accrual, screening, and 1-week and 1-month assessment completion will be tracked o The evaluation procedures will be considered feasible if we retain more than 80% of participants at 1-month follow-up.
Time frame: Baseline, Day 7, and Day 30
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for May 2027, 6 months later.
Of 1,295 non-industry interventional studies with no phase under Chronic Pain, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 39. This study's planned 6 months is below that.
Counting every sponsor, half of 1,378 studies reached it within 20 months; a quarter within 9 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Ottawa Hospital Research Institute →