An interventional study of AI-Guided Physical Therapy Program and Traditional Physical Therapy Program in Knee Osteoarthritis, sponsored by Cairo University. Not yet recruiting at 1 site in Egypt. Open to participants aged 45 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Among 26 studies in Osteoarthritis, Knee by Cairo University — 10 open to participants now, 12 under way, none of them phase 3. Osteoarthritis, Knee · Cairo University.
Among the 26 studies in Osteoarthritis, Knee by Cairo University, this one is the 19th largest by planned enrollment, is one of 3 that started in 2026, is one of 25 with no phase, reaches primary completion later than 10 of the 11 other live ones, and was the 26th registered.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 40 is below the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →10 of the 26 studies in Osteoarthritis, Knee by Cairo University are open now, in 1 country. Each count lists the studies.
Of the 382 Osteoarthritis, Knee studies recruiting now, 176 (46%) set no upper age limit and 113 (30%) stop at 75 or younger; 19 take children under 18; 39 take healthy volunteers.
This study: 45 Years to 70 Years · all sexes · no healthy volunteers.
The full table on the hub →26 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 3 started in 2026.
Median enrollment 60 across the 26 interventional studies. Of the 13 that completed or were terminated, 0 (0%) have results posted.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
2 of the studies in Osteoarthritis, Knee by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07774195Cairo UniversityEfficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis | 2026-11-21 |
| NCT07613749Cairo UniversityMECHANICAL TRACTION APPLIED BEFORE VERSUS AFTER THERAPEUTIC EXERCISES IN PRIMARY KNEE OSTEOARTHRITIS | 2027-07-01 |
Among the 26 studies in Osteoarthritis, Knee by Cairo University, from their registry updates:
Nothing recorded among them since 2026-09-25.
This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.
Forty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.
Both groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.
The study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.
This study is a prospective, single-blind, randomized controlled trial designed to compare the efficacy of an AI-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.
A total of 40 patients with knee osteoarthritis will be recruited from the Outpatient Clinic of the Faculty of Physical Therapy, Cairo University. Eligible participants will be aged 45-70 years and diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis. Participants will be randomly allocated into two equal groups.
The control group will receive a conventional physical therapy program consisting of transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. Treatment will be provided three times per week for 12 weeks.
The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4. Standardized patient information, including age, sex, pain intensity, functional disability, knee range of motion, symptom duration, and physical activity level, will be entered by the researcher to generate an evidence-based rehabilitation program for each participant.
Both groups will also receive education regarding lifestyle modification and joint protection strategies.
Outcome measures will be assessed before and after the intervention. Pain intensity will be evaluated using the Visual Analog Scale (VAS), knee range of motion using a digital goniometer, knee-related pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and functional mobility and fall risk using the Timed Up and Go (TUG) test.
The study will compare changes in these outcomes between the two groups to determine the relative efficacy of AI-guided and traditional physical therapy programs for patients with knee osteoarthritis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will receive an individualized AI-guided physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will then generate an evidence-based, in-clinic rehabilitation program for knee osteoarthritis. Participants will also receive education on lifestyle modification and joint protection strategies.
Other: AI-Guided Physical Therapy Program · Behavioral: Lifestyle Modification and Joint Protection Education
Participants in this arm will receive a conventional physical therapy program consisting of transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The program will be delivered three times per week for 12 weeks. Participants will also receive education on lifestyle modification and joint protection strategies.
Other: Traditional Physical Therapy Program · Behavioral: Lifestyle Modification and Joint Protection Education
Participants will receive an individualized physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will be prompted to generate an evidence-based, in-clinic rehabilitation program for adults with knee osteoarthritis.
Participants will receive a traditional physical therapy program including transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The intervention will be administered three sessions per week for 12 weeks.
Participants in both study arms will receive education on lifestyle modification and joint protection strategies as part of the management of knee osteoarthritis.
Pain Intensity
Pain intensity will be assessed using the Visual Analog Scale (VAS), a 10-cm scale ranging from 0 (no pain) to 10 (worst pain imaginable). Lower scores indicate less pain.
Time frame: 12 weeks
Knee Range of Motion
Active knee range of motion will be measured in degrees using a digital goniometer. Knee flexion and extension will be assessed before and after the intervention.
Time frame: 12 weeks
Knee Pain, Stiffness, and Physical Function
Knee-related pain, stiffness, and physical function will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The questionnaire includes 24 items covering pain, stiffness, and physical function. Higher scores indicate greater symptom severity and functional limitation.
Time frame: 12 weeks
Functional Mobility and Fall Risk
Functional mobility and fall risk will be assessed using the Timed Up and Go (TUG) test. Participants will stand from a chair, walk 3 meters, turn, return to the chair, and sit down. The time required to complete the task will be recorded in seconds; longer times indicate poorer functional mobility and greater fall risk.
Time frame: 12 weeks
Start is estimated for Aug 2026; primary completion for Nov 2026, 3 months later.
Of 1,111 non-industry interventional studies with no phase under Osteoarthritis, Knee, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 36. This study's planned 3 months is below that.
Counting every sponsor, half of 1,251 studies reached it within 18 months; a quarter within 8 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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