An interventional study of Temporomandibular Joint Arthrocentesis in Temporomandibular Disorders (TMDs) and Temporomandibular Joint Disc Displacement, Without Reduction, sponsored by Bahçeşehir University. Completed at 1 site in Turkey (Türkiye). Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Bahçeşehir University · Not applicable, Interventional, and Treatment
Among 150 studies in Temporomandibular Joint Disorders with a site in Turkey — 27 open to participants now, 28 under way, none of them phase 3. Temporomandibular Joint Disorders · Turkey.
Among the 150 studies in Temporomandibular Joint Disorders with a site in Turkey, this one is the 69th largest by enrollment of the 80 interventional ones, is one of 13 that started in 2019, is one of 76 with no phase, and was the 150th registered.
591 studies on the registry are indexed under Temporomandibular Joint Disorders; 149 are open to participants now.
This study's enrollment of 28 is below the median of 45 across 415 interventional studies indexed under Temporomandibular Joint Disorders.
Browse Temporomandibular Joint Disorders studies →27 of the 150 studies in Temporomandibular Joint Disorders with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 75 Temporomandibular Joint Disorders studies recruiting now, 26 (35%) set no upper age limit and 45 (60%) stop at 75 or younger; 7 take children under 18; 23 take healthy volunteers.
This study: all sexes · no healthy volunteers.
The full table on the hub →150 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 13 started in 2019.
Median enrollment 45 across the 80 interventional studies, 78 across the 70 observational. Of the 114 that completed or were terminated, 4 (4%) have results posted.
None of the 150 has an industry lead sponsor. The 10 most frequent:
Bahçeşehir University is the lead sponsor of 128 studies on the registry; 26 are open to participants now.
Bahçeşehir University has 5 studies filed under Temporomandibular Joint Disorders — fewer than ten, so there is no comparison to draw.
4 of the studies in Temporomandibular Joint Disorders with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07577687Yuzuncu Yil UniversityEffect of Emg-Biofeedback and Multimodal Exercise on Temporomandibular Joint Dysfunction | 2026-12-15 |
| NCT07850674Mustafa Kemal UniversitySpinal Mobility, Rigidity, and Kinesiophobia in PD and TMD | 2026-12-23 |
| NCT07576582Uşak UniversityPeloid Therapy in Temporomandibular Joint Dysfunction | 2027-01-01 |
| NCT07791173Zeynep Serra KalkanEvaluation of Temporomandibular Disorders During Pregnancy | 2027-03 |
Among the 150 studies in Temporomandibular Joint Disorders with a site in Turkey, from their registry updates:
This prospective comparative clinical study evaluates the clinical outcomes of temporomandibular joint arthrocentesis in patients diagnosed with disc displacement without reduction. Patients undergoing arthrocentesis as a first-line treatment are compared with patients undergoing arthrocentesis following an insufficient response to anti-inflammatory treatment. Pain intensity, assessed using a 0-10 Visual Analog Scale (VAS), and maximum mouth opening (MMO), measured in millimeters, are evaluated at baseline, immediately before arthrocentesis, and at 1 week, 1 month, and 3 months after the procedure.
Temporomandibular joint disc displacement without reduction (DDwoR) is associated with pain and restricted mandibular movement. Arthrocentesis is a minimally invasive treatment option for patients with this condition. However, the clinical outcomes of arthrocentesis performed as an initial treatment compared with arthrocentesis following anti-inflammatory therapy remain an area of clinical interest.
This prospective comparative clinical study includes 28 patients diagnosed with temporomandibular joint disc displacement without reduction.
Patients are evaluated in two groups:
Group A (n=13): Patients who undergo arthrocentesis as a first-line treatment without prior anti-inflammatory therapy.
Group B (n=15): Patients who initially receive 14 days of anti-inflammatory treatment and subsequently undergo arthrocentesis due to insufficient pain control.
All patients undergo temporomandibular joint arthrocentesis and receive a stabilization splint.
The clinical outcome measures are pain intensity, assessed using a 0-10 Visual Analog Scale (VAS), and maximum mouth opening (MMO), measured in millimeters.
For Group A, baseline and preoperative measurements represent the same assessment. For Group B, baseline measurements are obtained before anti-inflammatory treatment, while preoperative measurements are obtained after the medication period and immediately before arthrocentesis.
Postoperative evaluations are performed at 1 week, 1 month, and 3 months after arthrocentesis.
The study aims to compare changes in pain intensity and maximum mouth opening between the two treatment approaches, evaluating both postoperative improvement and overall clinical improvement from the initial assessment through the 3-month follow-up.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A line of therapy is one course of treatment, which may combine several drugs. First-line is the first course given; second-line follows when that stops working or is not tolerated.
“Two prior lines” means two courses that count separately under the study’s rules — not simply two drugs. Ask the study team if you are unsure how yours are counted.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Line of therapy
A line of therapy is one course of treatment, which may combine several drugs. First-line is the first course given; second-line follows when that stops working or is not tolerated.
“Two prior lines” means two courses that count separately under the study’s rules — not simply two drugs. Ask the study team if you are unsure how yours are counted.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with temporomandibular joint disc displacement without reduction who undergo arthrocentesis as the initial treatment without prior anti-inflammatory medication. A stabilization splint is provided following arthrocentesis.
Procedure: Temporomandibular Joint Arthrocentesis
Patients who initially receive 14 days of anti-inflammatory medication and subsequently undergo arthrocentesis due to insufficient pain control. A stabilization splint is provided following arthrocentesis.
Procedure: Temporomandibular Joint Arthrocentesis
Temporomandibular joint arthrocentesis is a minimally invasive procedure involving irrigation of the upper joint space to remove inflammatory mediators and improve joint mobility. The procedure is performed in both treatment groups.
Change in Maximum Mouth Opening (MMO)
Maximum mouth opening is measured in millimeters (mm) as the maximum interincisal distance. Changes in MMO are evaluated following temporomandibular joint arthrocentesis.
Time frame: Immediately before arthrocentesis and at 1 week, 1 month, and 3 months after arthrocentesis.
Change in Pain Intensity (VAS)
Pain intensity is assessed using a 0-10 visual analog scale (VAS), where 0 indicates no pain and 10 indicates the worst imaginable pain. Changes in pain intensity are evaluated following arthrocentesis.
Time frame: Immediately before arthrocentesis and at 1 week, 1 month, and 3 months after arthrocentesis.
Plan to share: No
No publications or documents are linked to this record.
Ran from Sep 2019 to primary completion in Jan 2023, 39 months.
Of 242 non-industry interventional studies with no phase under Temporomandibular Joint Disorders, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 21. This study's 39 months is above that.
Counting every sponsor, half of 246 studies reached it within 10 months; a quarter within 5 and three quarters within 21.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Temporomandibular Joint Disorders →