An observational study in Colorectal Adenoma, Cholecystectomy and Biliary Tract Diseases, sponsored by Nanjing First Hospital, Nanjing Medical University. Active, not recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-02.
Sponsored by Nanjing First Hospital, Nanjing Medical University · Observational
This study is a retrospective real-world study based on the electronic medical record database of Nanjing First Hospital. By integrating data from the hospital information system, ultrasound system, endoscopy system, pathology system, surgery and anesthesia system, medical record front pages, laboratory system, and electronic medical records, the study aims to evaluate the relationship between a history of cholecystectomy and biliary tract-related diseases and the detection risk of colorectal adenoma, and further analyze their associations with advanced lesions including advanced adenoma, high-grade intraepithelial neoplasia, adenoma carcinogenesis, or colorectal cancer. Additionally, it will explore the impact of different biliary disease subtypes, time intervals after cholecystectomy, and adenoma location on the study results. If the study finds that cholecystectomy or specific biliary diseases are associated with an increased risk of colorectal adenoma and advanced lesions, it may provide a reference for risk stratification of colorectal tumor screening and optimization of colonoscopy follow-up strategies for patients with biliary diseases; if no clear association is found, it may also provide evidence for clinically reasonable assessment of screening needs and avoidance of over-examination.
59 studies on the registry are indexed under Biliary Tract Diseases; 12 are open to participants now.
This study's enrollment of 8,450 is above the median of 414 across 18 observational studies indexed under Biliary Tract Diseases.
Browse Biliary Tract Diseases studies →Nanjing First Hospital, Nanjing Medical University is the lead sponsor of 224 studies on the registry; 110 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study subjects were adult patients who underwent biliary ultrasound examination and concurrently underwent colonoscopy or pan-colonoscopy at Nanjing First Hospital, Nanjing Hospital of Chinese Medicine, Wuhu Hospital of Traditional Chinese Medicine, Sir Run Run Hospital Nanjing Medical University, and Yangzhou Hospital of Traditional Chinese Medicine between January 2015 and December 2025. Based on data from the hospital information system, ultrasound system, endoscopy system, pathology system, surgery and anesthesia system, medical record front pages, laboratory system, and electronic medical records, cases meeting the inclusion and exclusion criteria will be screened.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with a history of cholecystectomy or biliary tract-related diseases prior to or concurrent with the baseline colonoscopy.
Other: No intervention. This is an observational study.
Patients without a history of cholecystectomy or biliary tract-related diseases prior to or concurrent with the baseline colonoscopy.
Other: No intervention. This is an observational study.
No intervention. This is an observational study.
Pathologically confirmed detection of colorectal adenoma
The primary outcome was the pathologically confirmed detection of colorectal adenoma, including tubular adenoma, tubulovillous adenoma, villous adenoma, traditional serrated adenoma, adenoma with low-grade intraepithelial neoplasia, and adenoma with high-grade intraepithelial neoplasia.
Time frame: The first colonoscopy during the study period that met the inclusion and exclusion criteria, i.e., the baseline colonoscopy.
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2016 to primary completion in Dec 2025, 119 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Nanjing First Hospital, Nanjing Medical University →