An interventional study of Extra-oral Cryotherapy and Intra-canal Cryotherapy in Irreversible Pulpitis and Apical Periodontitis, sponsored by Ahmad badrah. Completed at 1 site in Egypt. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Ahmad badrah · Not applicable, Interventional, and Treatment
Among 37 studies in Periapical Periodontitis with a site in Egypt — 11 open to participants now, 16 under way, 2 of them phase 3. Periapical Periodontitis · Egypt.
Among the 37 studies in Periapical Periodontitis with a site in Egypt, this one is the 22nd largest by enrollment, is one of 7 that started in 2025, is one of 30 with no phase, and was the 36th registered.
280 studies on the registry are indexed under Periapical Periodontitis; 79 are open to participants now.
Browse Periapical Periodontitis studies →11 of the 37 studies in Periapical Periodontitis with a site in Egypt are open now. Recruiting first, the newest first:
October 6 University · Sites in Egypt
Ages 21–50
Minia University · Sites in Egypt
Ages 22–45 · Healthy volunteers
October 6 University · Sites in Egypt
Ages 18–60 · Healthy volunteers
Misr International University · Sites in Egypt
Ages 20–45 · Healthy volunteers
Cairo University · Sites in Egypt
Ages 18–40 · Healthy volunteers
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 43 Periapical Periodontitis studies recruiting now, 17 (40%) set no upper age limit and 25 (58%) stop at 75 or younger; 5 take children under 18; 21 take healthy volunteers.
This study: 18 Years to 45 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
37 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 3 · Phase 2 4 · Phase 3 2
First in 2019; this study’s year is marked. 7 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 40 is below the median of 60 across 245 interventional studies indexed under Periapical Periodontitis.
Median enrollment 45 across the 37 interventional studies. Of the 20 that completed or were terminated, 1 (5%) have results posted.
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None of the 37 has an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Ahmad badrah as lead sponsor.
Ahmad badrah has 1 study filed under Periapical Periodontitis — fewer than ten, so there is no comparison to draw.
7 of the studies in Periapical Periodontitis with a site in Egypt that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07762248Phase 3Mohamed Ashraf AbdeenImpact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis | 2027-09 |
| NCT07906808October 6 UniversityEffect of Ultrasonic and Diode Laser Activated Irrigation on Postoperative Pain Following Root Canal Treatment | 2026-12-15 |
| NCT07897591October 6 UniversityConventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis | 2027-01 |
| NCT07916987Cairo UniversityInfluence of Continuous Rotation Versus Reciprocation Motion of MG3 Blue Rotary File on Postoperative Pain and Intracanal Bacterial Reduction of Teeth With Necrotic Pulps. | 2027-01 |
| NCT07603934Cairo UniversityThe Effect of Different Intra-canal Medications on Postoperative Pain | 2027-02-15 |
Add all 7 to your calendar (.ics) → With an account.
Among the 37 studies in Periapical Periodontitis with a site in Egypt, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This randomized controlled clinical trial evaluates the effect of different methods of cryotherapy (extra-oral, intra-canal, and combination) on postoperative pain and periapical Substance P levels in patients with acute irreversible pulpitis and symptomatic apical periodontitis. Forty participants will be divided into four groups to compare the therapeutic benefits of cold applications in endodontic treatment
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will receive conventional root canal treatment accompanied by extra-oral cryotherapy application
Procedure: Extra-oral Cryotherapy
Patients will receive conventional root canal treatment accompanied by intra-canal cryotherapy application
Procedure: Intra-canal Cryotherapy
Patients will receive conventional root canal treatment accompanied by both intra-canal and extra-oral cryotherapy application
Procedure: Combination (extra-oral and intra-canal)
Conventional endodontic treatment without cryotherapy
Procedure: Conventional Endodontic Treatment
Application of extra-oral cold packs (on the cheek) for 30 minutes after the conventional root canal treatment
Application of intra-canal cold (2-4°C) 2.5% NaOCl irrigation after the conventional root canal treatment
Received both extra-oral gel pack and intra-canal cold NaOCl applications (as previous) after the conventional root canal treatment
Standard root canal treatment without the application of cryotherapy
Postoperative Pain
Assessment of postoperative pain intensity using the Visual Analog Scale (VAS) or Numerical Rating Scale (NRS) at specific intervals
Time frame: Measured at 6, 12, 24, and 48 hours and 1 week postoperatively
substance P (SP) Levels
Evaluation of Substance P concentration in periapical tissue fluid as a biochemical marker for inflammation
Time frame: Assessed immediately after the conventional root canal preparation, and subsequently after the application of cryotherapy for the experimental groups or after 30 minutes for the control group
Plan to share: Yes
No publications or documents are linked to this record.
Ran from Aug 2025 to primary completion in Feb 2026, 5 months.
Of 171 non-industry interventional studies with no phase under Periapical Periodontitis, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 19. This study's 5 months is below that.
Counting every sponsor, half of 172 studies reached it within 12 months; a quarter within 6 and three quarters within 19.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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