A Phase 2/3 interventional study of Root canal treatment in Necrotic Mandibular Molars and Apical Periodontitis, sponsored by Mohamed Ashraf Abdeen. Not yet recruiting at 1 site in Egypt. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-08-13.
Sponsored by Mohamed Ashraf Abdeen · Phase 2/3, Interventional, and Treatment
Among 37 studies in Periapical Periodontitis with a site in Egypt — 11 open to participants now, 16 under way, 2 of them phase 3. Periapical Periodontitis · Egypt.
Among the 37 studies in Periapical Periodontitis with a site in Egypt, this one is the 7th largest by planned enrollment, is one of 8 that started in 2026, is one of 2 in phase 2/3, reaches primary completion later than 14 of the 15 other live ones, and was the 29th registered.
280 studies on the registry are indexed under Periapical Periodontitis; 79 are open to participants now.
Browse Periapical Periodontitis studies →11 of the 37 studies in Periapical Periodontitis with a site in Egypt are open now. Recruiting first, the newest first:
October 6 University · Sites in Egypt
Ages 21–50
Minia University · Sites in Egypt
Ages 22–45 · Healthy volunteers
October 6 University · Sites in Egypt
Ages 18–60 · Healthy volunteers
Misr International University · Sites in Egypt
Ages 20–45 · Healthy volunteers
Cairo University · Sites in Egypt
Ages 18–40 · Healthy volunteers
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 43 Periapical Periodontitis studies recruiting now, 17 (40%) set no upper age limit and 25 (58%) stop at 75 or younger; 5 take children under 18; 21 take healthy volunteers.
This study: 20 Years to 50 Years · all sexes · no healthy volunteers.
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37 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 3 · Phase 2 4 · Phase 3 2
First in 2019; this study’s year is marked. 8 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is close to the median of 60 across 245 interventional studies indexed under Periapical Periodontitis.
Median enrollment 45 across the 37 interventional studies. Of the 20 that completed or were terminated, 1 (5%) have results posted.
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None of the 37 has an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Mohamed Ashraf Abdeen as lead sponsor.
Mohamed Ashraf Abdeen has 1 study filed under Periapical Periodontitis — fewer than ten, so there is no comparison to draw.
7 of the studies in Periapical Periodontitis with a site in Egypt that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07762248Phase 3Mohamed Ashraf AbdeenImpact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis | 2027-09 |
| NCT07906808October 6 UniversityEffect of Ultrasonic and Diode Laser Activated Irrigation on Postoperative Pain Following Root Canal Treatment | 2026-12-15 |
| NCT07897591October 6 UniversityConventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis | 2027-01 |
| NCT07916987Cairo UniversityInfluence of Continuous Rotation Versus Reciprocation Motion of MG3 Blue Rotary File on Postoperative Pain and Intracanal Bacterial Reduction of Teeth With Necrotic Pulps. | 2027-01 |
| NCT07603934Cairo UniversityThe Effect of Different Intra-canal Medications on Postoperative Pain | 2027-02-15 |
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Among the 37 studies in Periapical Periodontitis with a site in Egypt, from their registry updates:
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Statement of the problem: The effectiveness of minimally invasive endodontic treatments in managing necrotic pulp with apical periodontitis remains understudied. Aim of the study: This research aims to evaluate the outcomes of minimally invasive versus traditional root canal treatments in patients with necrotic pulp associated with apical periodontitis. Material and methods: sixty healthy patients of both genders aged from 20 to 50 years old suffering from necrotic pulp associated with apical periodontitis in their lower first molars with four root canals will be included in this study. The initial assessment will include a preoperative CBCT scan. Participants will be randomly assigned according to the type of endodontic treatment to two groups; a traditional treatment group (Trad); in which a traditional access cavity design and root canal preparation extending three sizes beyond the initial apical file using taper .04 rotary files will be accomplished and a minimally invasive group (MI) in which a conservative access cavity and a conservative root canal preparation up to #20/.04 will be performed. Both groups will receive an identical irrigation protocol during root canal instrumentation augmented with passive ultrasonic activation. Immediately following biomechanical preparation, the root canals will be filled with single cone obturation technique. Root canal disinfection will be evaluated using a culture method in which two bacterial samplings will be collected, one before and another after the biomechanical preparation. Patients will be monitored over 12 months, concluding with a follow-up CBCT scan to assess periapical healing. Data will be collected and statistically analyzed.
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Exclusion Criteria:
In this group traditional access cavity and canal preparations is done
Procedure: Root canal treatment
In this group conservative access cavity and minimally invasive root canal preparation is done
Procedure: Root canal treatment
Root canal treatment is done
Success rate
A case is deemed successful if there is no clinical signs and symptoms of infection or inflammation and radiographic bone healing. The success rate for each group will be determined by the ratio of successful cases to the total number of cases in that group.
Time frame: 1 year follow up
Healing of periapical lesion
The change in the size of periapical radiolucencies will be assessed through a comparison of CBCT images taken preoperatively and at the 12-month follow-up. This evaluation will be conducted by two independent operators who are not aware of the treatment group assignments to ensure unbiased results.
Time frame: 1 year
Bacterial load
The bacterial levels within the root canals will be quantified at two critical stages of the treatment process: S1: Immediately following the creation of the access cavity, prior to initiating any cleaning or shaping procedures. This step is crucial for determining the initial bacterial load present in the root canal system. S2: Following irrigant activation. This measurement will provide insight into the efficacy of the cleaning and shaping procedures, as well as the irrigation protocol, in reducing the bacterial population within the canal. These bacterial samples will be collected using sterile a three size #15 paper points which will be inserted into the canals to absorb the canal contents. This method ensures a standardized approach to bacterial sampling at these specified stages of the treatment.
Time frame: Within 2 days after intervention
Treatment duration
The total time taken to complete the treatment procedure, from the beginning of the access cavity preparation to the completion of obturation, will be meticulously recorded for each case.
Time frame: During procedure
Iatrogenic errors
Any occurrences of iatrogenic errors, such as instrument separation, will be noted and recorded. This data will provide insight into the potential risks associated with each treatment approach.
Time frame: During procedure
Plan to share: Yes — All collected IPD
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: Beginning after publication of results and ending after 2 years
No publications or documents are linked to this record.
Start is estimated for Jul 2026; primary completion for Sep 2027, 14 months later.
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This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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