An observational study in Cardiac Arrest (CA), sponsored by Children's Hospital of Philadelphia. Recruiting at 22 sites in United States. Open to participants aged 37 Weeks to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Children's Hospital of Philadelphia · Observational
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.
984 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's planned enrollment of 1,620 is above the median of 196 across 394 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →Children's Hospital of Philadelphia is the lead sponsor of 488 studies on the registry; 91 are open to participants now.
Of its 28 completed or terminated interventional studies of FDA-regulated products, 22 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Data will be collected from pediatric cardiac arrest events as part of standard clinical operations.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Pediatric cardiac arrests requiring chest compressions for at least 1 minute occurring in an ICU identified as part of standard clinical operations.
Return of Spontaneous Circulation (ROSC) lasting 20 minutes
Sustained return of ROSC ≥20 minutes
Time frame: Duration of CPR event through 20 minutes after CPR
Survival with a favorable neurologic outcome
Survival to hospital discharge with a favorable neurologic outcome (Pediatric Cerebral Performance Category (PCPC) score (scored on a scale of 1-6) at hospital discharge of 1 (normal), 2 (mild disability) or no worse than baseline).
Time frame: From baseline (assessed prior to admission, or new in-hospital baseline assessed no more than 30 days prior to cardiac arrest for patients hospitalized >90 days) to the assessment at hospital discharge, estimated average of 6-12 months
Survival with no new morbidity (change in Functional Status Score (FSS) from baseline of < 3 points)
FSS is scored on a scale of 1-5 (lower number is better function) across 6 functional categories (mental status, sensory, communication, motor function, feeding, respiratory).
Time frame: From baseline (assessed prior to admission, or new in-hospital baseline assessed no more than 30 days prior to cardiac arrest for patients hospitalized >90 days) to the assessment at hospital discharge, estimated average of 6-12 months
Plan to share: Yes — At the conclusion of the study, we will create a public use data set containing all analytical variables. The public use data set will contain a randomly generated subject ID but will not contain any personal or site identifiers. The cleaned, item-level spreadsheet data for all variables will be shared openly, along with example quantifications and transformations from initial raw data. Final files used to generate specific analyses to answer the Specific Aims and related results will also be shared.
Supporting information: Study protocol, Statistical analysis plan
Time frame: The public use data set will be made available within three months of completion of the primary manuscript. If the primary manuscript isn't published within 12 months of the end of funding, we will proceed with publishing the public use data set. The duration of preservation and sharing of the data will be a minimum of 10 years after the funding period.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Children's Hospital of Philadelphia →