An interventional study of Cryoneurolysis in Ventral Hernia, Incisional Hernia and Hernia, sponsored by University of South Florida. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by University of South Florida · Not applicable, Interventional, and Basic science
The goal of this clinical trial is to learn if cryoneurolysis, a targeted cold therapy applied to nerve branches, can relax the muscles of the abdomen to facilitate surgical repair of abdominal wall hernias. The main questions it aims to answer are:
Participants will
258 studies on the registry are indexed under Hernia, Ventral; 46 are open to participants now.
This study's planned enrollment of 10 is below the median of 95 across 163 interventional studies indexed under Hernia, Ventral.
Browse Hernia, Ventral studies →University of South Florida is the lead sponsor of 338 studies on the registry; 63 are open to participants now.
Of its 17 completed or terminated interventional studies of FDA-regulated products, 4 (24%) have results posted.
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Exclusion Criteria:
Device: Cryoneurolysis
Targeted cold therapy to the motor nerve branches of the abdominal oblique muscles to temporarily relax the muscles before hernia repair.
Change from baseline in Computed Tomography (CT) measured length of oblique muscles and hernia defect size in centimeters
CT obtained 1-2 weeks post cryoneurolysis procedure will be compared to baseline CT to determine change in oblique muscle complex length and maximal transverse hernia defect size in centimeters
Time frame: 2 weeks
Summary of treatment related adverse events
Telephone survey will assess for bruising, swelling, redness, altered sensation, pain, other patient reported side effects 24-48 hours post cryoneurolysis. Standard postoperative complications after hernia repair including surgical site infection, surgical site occurrence, major complication (Clavien Dindo \>=3), and mortality, or any other patient reported adverse event will be collected through 30 day postoperative clinic visit
Time frame: Telephone survey 48 hours post cryoneurolysis procedure through 30 day postoperative follow up after hernia repair
Rate of primary fascial closure and need for surgical component separation at the time of hernia repair
The investigators will prospectively capture intraoperative outcomes including rate of primary fascial closure, need for and type of component separation performed
Time frame: At the time of surgery which will occur between 2-6 weeks post cryoneurolysis procedure
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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