An observational study in STEMI, NSTEMI and Chronic Coranary Sindrome, sponsored by A.O.U. Città della Salute e della Scienza. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by A.O.U. Città della Salute e della Scienza · Observational
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk score able to estimate the risk of MACE during follow-up based on OCT findings observed on coronary plaques not subjected to percutaneous coronary intervention (PCI) and on the clinical characteristics of the patients.
We will collect information on all non-PCI coronary lesions assessed by performing OCT in non-culprit vessels of patients presenting with ACS or Chronic Coronary Syndrome (CCS) at the index procedure. All OCT runs will be digitized and analyzed with the help of AI. The OCT appearance of coronary plaques will be analyzed with AI and correlated with the risk of MACE during follow-up (a composite of cardiac death, myocardial infarction, or target lesion revascularization). An AI predictive risk model based on coronary plaque OCT images and patient clinical characteristics will be developed to estimate the risk of MACE incidence at follow-up. Cutting-edge machine learning algorithms, including convolutional neural networks, random forests, and support vector machines, will be used.
688 studies on the registry are indexed under ST Elevation Myocardial Infarction; 184 are open to participants now.
This study's enrollment of 600 is above the median of 335 across 229 observational studies indexed under ST Elevation Myocardial Infarction.
Browse ST Elevation Myocardial Infarction studies →A.O.U. Città della Salute e della Scienza is the lead sponsor of 65 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Men and women over 18 years of age, presenting with STEMI - NSTEMI - CCS - UA.
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Exclusion Criteria:
MACE
Composite end point of all cause death, MI, urgent revascularization and TVR
Time frame: 12 months
MACCE
composite end point of CV death, MI, urgent revascularization and TVR
Time frame: 12 months
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2023 to primary completion in Jul 2026, 42 months.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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ST Elevation Myocardial Infarction →
A.O.U. Città della Salute e della Scienza