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CompletedNCT07864532PDTNCCPUpdated Oct 7, 2026

Prevalence and Determinants of Therapeutic Non-Compliance in Patients With Chronic Pathologies ( PDTNCCP)

An observational study in Adherence, Medication, sponsored by University of Monastir. Completed at 1 site in Tunisia. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-10-07.

Sponsored by University of Monastir · Observational

Updated Oct 7, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,000
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Identify the prevalence and determinants related to therapeutic non adherence among patients with chronic pathologies and to design effective interventions optimizing treatment compliance.

Read the detailed description

Medication non-adherence is a major problem leading to accelerated disease progression, increased morbidity and mortality, and additional costs to health systems.This is why the main objectif of this study is to identify factors that influence therapeutic adherence and to design effective interventions optimizing treatment compliance.

This study is a cross-sectional descriptive survey taking place at the emergency department of the Fattouma Bourguiba hospital in Monastir and at regional hospitals of the city of Monastir.

02

Conditions studied

  • Adherence, Medication

Keywords

  • Therapeutic non-compliance
  • Prevalence
  • Chronic Pathologies
  • Diabetes
  • Chronic Heart Failure
  • Obstructive Pulmonary Disease
  • Arterial Hypertension
03

In context

Medication Adherence

240 studies on the registry are indexed under Medication Adherence; 111 are open to participants now.

This study's enrollment of 3,000 is above the median of 200 across 35 observational studies indexed under Medication Adherence.

Browse Medication Adherence studies →

Lead sponsor

University of Monastir is the lead sponsor of 114 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients with a prescription for a chronic disease and who accept to enroll in this study.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with a history of arterial hypertension (HTA), diabetes, obstructive pulmonary disease (COPD), and heart failure (HF), isolated or combined.
  • Patients who have been under treatment for more than 6 months.

Exclusion criteria

Exclusion Criteria:

  • Non-cooperative or non-consenting patients.
  • Patients unable to understand spoken words, such as those with visual or hearing impairment.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,000 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Adherence measured using the 8-item Morisky Medication Adherence Scale (MMAS-8)

    Medication adherence will be assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). The scale assesses patients' medication-taking behavior, including forgetting doses, discontinuing treatment, difficulties with daily medication use, and other behaviors related to medication adherence. The MMAS-8 score ranges from 0 to 8, with higher scores indicating higher medication adherence.

    Time frame: Baseline

Secondary outcomes

  1. Factors associated with medication adherence

    Demographic, clinical, and treatment-related characteristics will be collected and analyzed to identify factors associated with medication adherence as measured by the MMAS-8 score.

    Time frame: Baseline

07

Study locations

1 site
  • Nouira
    Monastir, 5060, Tunisia
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 7, 2026
Show all 1 update
  1. Oct 7, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07864532
Responsible party
Pr. Semir Nouira (Professor, University of Monastir) — Principal investigator
First posted
Oct 7, 2026
Start date
Mar 1, 2024
Primary completion
May 31, 2024
Completion
Jun 30, 2025
Last update
Oct 7, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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