An interventional study of Advanced Platelet-Rich Fibrin and Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite in Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin and Strontium-Doped Hydroxyapatite, sponsored by Kafrelsheikh University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Treatment
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with spontaneous socket healing.
Tooth extraction is one of the most common procedures performed in dental practice and is frequently followed by physiologic remodeling of the alveolar process.
Alveolar ridge preservation has therefore become an essential component of contemporary oral and maxillofacial surgery. Various techniques have been developed to minimize post-extraction bone loss, including the use of autogenous bone, allografts, xenografts, alloplastic materials, barrier membranes, and biologically active agents.
Advanced platelet-rich fibrin (A-PRF), a second-generation platelet concentrate prepared without anticoagulants or biochemical additives, forms a three-dimensional fibrin matrix enriched with platelets, leukocytes, and circulating stem cells.
Strontium-doped hydroxyapatite (Sr-HA) has emerged as a promising synthetic bone substitute because of its favorable osteoconductive and bioactive properties. Incorporation of strontium ions into the hydroxyapatite crystal lattice enhances bone remodeling by simultaneously stimulating osteoblastic activity and inhibiting osteoclastic bone resorption.
Kafrelsheikh University is the lead sponsor of 294 studies on the registry; 114 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Extraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct.
Other: Heal spontaneously without placement of any grafting material
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction.
Drug: Advanced Platelet-Rich Fibrin
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation.
Drug: Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction.
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation.
Extraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct.
Assessment of bone density
Radiographic bone density within the extraction socket was assessed using cone-beam computed tomography (CBCT) and standardized image-analysis software by an examiner blinded to treatment allocation.
Time frame: 6 months after tooth extraction
Change in Alveolar Ridge Width
Change in horizontal alveolar ridge width, measured in millimeters using cone-beam computed tomography (CBCT), relative to the immediate post-extraction baseline.
Time frame: 6 months after tooth extraction
Change in Alveolar Ridge Height
Change in vertical alveolar ridge height, measured in millimeters using cone-beam computed tomography (CBCT), relative to the immediate post-extraction baseline.
Time frame: 6 months after tooth extraction
Incidence of postoperative complications
Incidence of postoperative complications including edema, infection, graft exposure, and wound dehiscence were recorded.
Time frame: 6 months after tooth extraction
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
Time frame: After the end of study for one year.
Access criteria: The data will be available upon a reasonable request from the corresponding author.
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Dec 2027, 16 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.