ClinicalTrials.gg
RecruitingNCT07838545Updated Sep 24, 2026

Comparative Effects of Post Isometric Relaxation and Reciprocal Inhibition in Individuals With Cervicogenic Headache.

An interventional study of Post Isometric Relaxation and Reciprocal Inhibition in Post Traumatic Headache and Cervicogenic Headache, sponsored by Foundation University Islamabad. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-09-24.

Sponsored by Foundation University Islamabad · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 7 months after the study started (first participant enrolled Feb 2026, registered Sep 2026).
  • Started Feb 2026; still recruiting 8 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
46
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

This study aims to compare the effects of Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI) in individuals with cervicogenic headache, a secondary headache originating from dysfunction of the cervical spine, particularly the upper cervical segments. Cervicogenic headache is characterized by unilateral head and neck pain, restricted cervical mobility, muscle tightness, and functional limitations that negatively affect daily activities and quality of life. The study will employ a randomized controlled trial involving 46 participants aged 18-45 years who meet the inclusion criteria. Participants will be randomly allocated into two groups: Group A will receive Post Isometric Relaxation, while Group B will receive Reciprocal Inhibition. Both groups will also receive a standard physiotherapy protocol consisting of hot packs, cervical isometric exercises, and C1-C2 Sustained Natural Apophyseal Glides (SNAGs), administered three times per week for four weeks. Pain intensity, functional disability, and cervical range of motion will be assessed before and after the intervention using the Numeric Pain Rating Scale (NPRS), Neck Disability Index (NDI), and goniometric measurements, respectively. By comparing these two muscle energy techniques, the study seeks to determine which intervention is more effective in reducing pain, improving cervical mobility, and enhancing functional outcomes, thereby providing evidence to support clinical decision-making and optimize physiotherapy management for individuals with cervicogenic headache.

Read the detailed description

"Comparative Effects of Post Isometric Relaxation and Reciprocal Inhibition in Individuals with Cervicogenic Headache," is designed to compare the effectiveness of two muscle energy techniques-Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI)-in reducing pain, improving cervical range of motion, and decreasing functional disability among individuals with cervicogenic headache (CGH). Cervicogenic headache is defined as a secondary headache caused by disorders of the cervical spine or its associated bony, disc, or soft tissue structures. It typically presents as unilateral pain that begins in the neck or occipital region and radiates toward the front of the head. Patients often experience restricted neck movement, cervical stiffness, muscle tightness, and occasionally ipsilateral shoulder or arm discomfort. These symptoms may significantly interfere with daily activities, work performance, and overall quality of life. The condition is commonly associated with dysfunction of the upper cervical spine, particularly the C1-C2 segment, where altered joint mobility and muscle imbalance contribute to the development and persistence of symptoms. The synopsis highlights that cervicogenic headache is a common musculoskeletal disorder with a considerable health burden worldwide. It is frequently triggered or aggravated by sustained neck postures, repetitive cervical movements, or prolonged physical activity. Diagnosis requires a detailed subjective and physical examination, with particular emphasis on assessing upper cervical mobility. The Cervical Flexion-Rotation Test (CFRT) is identified as a reliable and valid clinical test for confirming cervicogenic headache because it specifically evaluates C1-C2 rotation, which is often limited in affected individuals. Patients with CGH also commonly exhibit tightness in muscles such as the upper trapezius, levator scapulae, sternocleidomastoid, scalene, suboccipital muscles, and pectoral muscles, making manual therapy an important component of rehabilitation. The study focuses on two commonly used muscle energy techniques. Post Isometric Relaxation (PIR) is based on the principle that following an isometric muscle contraction, muscle tone decreases temporarily, allowing the therapist to gently stretch the muscle into a new range of motion. During the technique, the therapist applies resistance while the patient performs a gentle isometric contraction for a specified duration, after which the muscle is passively stretched. This process aims to reduce muscle tightness, improve flexibility, restore normal muscle length, and increase cervical mobility. Reciprocal Inhibition (RI), in contrast, relies on the physiological inhibition of a tight muscle through isometric contraction of its antagonist. When the antagonist contracts, the agonist muscle experiences reduced muscle tone, allowing a more effective passive stretch. Both techniques are intended to relieve pain, restore normal muscle function, and improve joint mobility in patients with cervicogenic headache. The rationale for this research is based on evidence from previous studies demonstrating the effectiveness of manual therapy and muscle energy techniques in treating neck pain and cervicogenic headache. Earlier research has shown that PIR, hold-relax techniques, SNAGs, and other manual therapy interventions significantly reduce pain, improve cervical range of motion, and decrease disability. However, limited evidence directly compares PIR and RI in individuals with cervicogenic headache. Therefore, this study seeks to determine which of these two techniques provides superior clinical outcomes and may guide physiotherapists in selecting the most effective treatment approach. The research will be conducted as a randomized controlled trial (RCT) over one year at the Foundation University College of Physical Therapy. A total of 46 participants, aged 18-45 years, diagnosed with cervicogenic headache according to the International Classification of Headache criteria, will be recruited using non-probability purposive sampling. Eligible participants must have unilateral neck pain associated with headache for more than three months, headache provoked by neck movement or sustained postures, restricted upper cervical mobility, and a positive Cervical Flexion-Rotation Test with a restriction greater than 10 degrees. Individuals with recent cervical trauma, cervical surgery, neoplasms, inherited spinal deformities, cognitive impairment, or other chronic pain syndromes will be excluded to ensure a more homogeneous study population. Participants will be randomly allocated into two equal groups using sealed opaque envelopes. Group A will receive Post Isometric Relaxation, while Group B will receive Reciprocal Inhibition. Both groups will receive the same standard physiotherapy protocol consisting of a 10-minute hot pack, cervical isometric exercises (10 repetitions with a 5-second hold), and C1-C2 Sustained Natural Apophyseal Glides (SNAGs) (10 repetitions with a 5-second hold). Treatment sessions will be conducted three times per week for four weeks, resulting in a total of twelve treatment sessions. PIR and RI techniques will be applied to muscles commonly involved in cervicogenic headache, including the upper trapezius, levator scapulae, suboccipital muscles, and sternocleidomastoid, using standardized positioning, therapist resistance, isometric contractions, and gentle stretching procedures. The effectiveness of the interventions will be assessed using validated outcome measures. Pain intensity will be evaluated using the Numeric Pain Rating Scale (NPRS), functional disability will be measured using the Neck Disability Index (NDI), and cervical range of motion will be assessed with a goniometer. Baseline measurements will be recorded before treatment begins, and the same assessments will be repeated after completion of the twelfth treatment session. These outcome measures will allow comparison of changes in pain severity, neck function, and cervical mobility between the two intervention groups. The study emphasizes that identifying the more effective muscle energy technique could improve evidence-based physiotherapy management of cervicogenic headache. The findings may help clinicians make informed treatment decisions by determining whether Post Isometric Relaxation or Reciprocal Inhibition provides greater improvements in pain reduction, cervical mobility, and functional ability. Ultimately, the study aims to enhance patient outcomes, improve quality of life, reduce disability associated with cervicogenic headache, and contribute to the growing body of evidence supporting manual therapy interventions in musculoskeletal physiotherapy. Additionally, the research follows ethical principles by obtaining informed consent from all participants, ensuring confidentiality, allowing voluntary withdrawal from the study at any stage, and maintaining equal treatment without discrimination throughout the research process.

02

Conditions studied

  • Post Traumatic Headache
  • Cervicogenic Headache
03

In context

Post-Traumatic Headache

192 studies on the registry are indexed under Post-Traumatic Headache; 54 are open to participants now.

This study's planned enrollment of 46 is close to the median of 44 across 169 interventional studies indexed under Post-Traumatic Headache.

Browse Post-Traumatic Headache studies →

Lead sponsor

Foundation University Islamabad is the lead sponsor of 255 studies on the registry; 142 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients are diagnosed according to ICH criteria.
  • Age 18-45 years.
  • Both Genders (Male and Female).
  • Headache > 3 months.
  • Unilateral neck pain and associated headache.
  • Headache is precipitated by neck movements or sustained positions.
  • Restricted upper cervical segmental mobility.
  • Positive cervical flexion rotation test, restriction greater than 10°.

Exclusion criteria

Exclusion criteria

  • History of head and neck trauma.
  • Neoplasm.
  • Cognitive disability.
  • Inherited disorders such as scoliosis and torticollis.
  • Other chronic pain syndrome (i.e.: fibromyalgia, systematic inflammatory disease).
  • History of recent surgery of cervical spine.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
46 participants (estimated)

Study arms

  • Experimental
    Group A Post Isometric Relaxation

    Procedure: Post Isometric Relaxation

  • Experimental
    Group B Reciprocal Inhibition

    Procedure: Reciprocal Inhibition

Interventions

  • ProcedurePost Isometric Relaxation

    Post Isometric Relaxation (PIR) is a muscle energy technique used to reduce pain, decrease muscle tightness, and improve cervical mobility in individuals with cervicogenic headache. The technique is based on the principle that muscle tone temporarily decreases after a gentle isometric contraction, allowing the muscle to be stretched more effectively. During the intervention, the therapist positions the affected muscle at its resistance barrier and asks the patient to perform a 10-second isometric contraction against therapist-applied resistance. After relaxation, a gentle passive stretch is applied to achieve a new range of motion. The procedure is repeated 3-5 times for each targeted muscle, including the upper trapezius, levator scapulae, suboccipital, and sternocleidomastoid muscles.

  • ProcedureReciprocal Inhibition

    Reciprocal Inhibition (RI) is a muscle energy technique used to reduce muscle tightness, relieve pain, and improve cervical range of motion by utilizing the neurological principle of reciprocal inhibition. During the technique, the therapist positions the patient appropriately and instructs the patient to perform a gentle 10-second isometric contraction of the antagonist muscle against therapist-applied resistance. This contraction inhibits the activity of the tight agonist muscle, resulting in decreased muscle tone and facilitating relaxation. Following the contraction, the therapist applies a gentle passive stretch to the affected muscle to achieve a new range of motion. The technique is repeated 3-5 times for each targeted muscle to improve flexibility and cervical function.

06

What researchers measure

Primary outcomes

  1. Head Pain

    Pain intensity will be assessed using the Numeric Pain Rating Scale(NPRS).The NPRS is an 11-point self reported scale ranging from 0 to 10,where 0 indicates no pain and 10 reprents the worst pain.

    Time frame: Baseline and after 4 weeks of intervention

  2. Cervical Range of Motion

    Cervical range of motion (ROM) will be assessed as an outcome measure using a goniometer. The assessment will be performed before the intervention and after completion of the treatment protocol to determine changes in cervical mobility. The cervical movements assessed will include flexion, extension, right and left lateral flexion, and right and left rotation. The participant will be positioned appropriately, and the goniometer will be aligned according to the anatomical landmarks for each movement. The available cervical ROM will be measured in degrees and recorded on the data collection form. Goniometry has demonstrated good reliability for assessing cervical ROM, with reported intraclass correlation coefficients (ICC) ranging from 0.79 to 0.98.

    Time frame: Baseline and after 4 weeks of treatment

  3. Neck Disability

    Neck disability will be assessed as an outcome measure using the Neck Disability Index (NDI). The NDI is a valid and reliable self-report questionnaire designed to evaluate the level of disability associated with neck pain and its effects on daily activities. It consists of 10 items covering pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping, and recreation. Each item is scored from 0 to 5, with higher scores indicating greater disability. The total score ranges from 0 to 50 and is used to determine the severity of functional disability. A score of 0-4 indicates no disability, 5-14 mild disability, 15-24 moderate disability, 25-34 severe disability, and 35 or more complete disability.

    Time frame: Baseline and after 4 weeks of treatment

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Feb 2026 (actual). Primary completion is estimated for Dec 2026, 10 months after the start.

Of 89 non-industry interventional studies with no phase under Post-Traumatic Headache, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 26. This study's planned 10 months is close to that.

Counting every sponsor, half of 90 studies reached it within 12 months; a quarter within 5 and three quarters within 26.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 18, 2026
First posted
Sep 24, 2026
StartActual
Feb 12, 2026
Primary completionEst.
Dec 18, 2026
CompletionEst.
Jan 18, 2027
Last update
Sep 24, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07838545
Responsible party
Sponsor
First posted
Sep 24, 2026
Start date
Feb 12, 2026
Primary completion
Dec 18, 2026 (estimated)
Completion
Jan 18, 2027 (estimated)
Last update
Sep 24, 2026

Study contacts

Kinza Hafeez, DPT
Contact
hafeezkinza56@gmail.com
+923045695710
Anam Rehman, MS-OMPT
Contact
anam.rehman@fui.edu.pk
+923355082299

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion