An observational study in Cervicogenic Headache and Chronic Neck Pain, sponsored by Istanbul Medipol University Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 25 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by Istanbul Medipol University Hospital · Observational
The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck. Neck pain may affect posture, muscle function, grip strength, and sensitivity to pressure. Researchers do not know whether CGH has a distinct pattern of these findings.
The main questions are:
Researchers will compare adults ages 25 through 60. One group will include people with CGH lasting at least three months. Another group will include people with neck pain lasting at least six months. People in the neck pain group will have no headaches. Healthy participants will have no neck pain or headaches.
Researchers will not provide treatment or change participants' usual care. Each participant will complete one study visit lasting about 15 minutes. Participants will:
Researchers will compare results across the three groups. The findings may guide future CGH assessment and treatment research.
192 studies on the registry are indexed under Post-Traumatic Headache; 54 are open to participants now.
This study's planned enrollment of 135 is above the median of 90 across 21 observational studies indexed under Post-Traumatic Headache.
Browse Post-Traumatic Headache studies →Istanbul Medipol University Hospital is the lead sponsor of 366 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population consists of adults aged 25-60 years recruited at the study site in Istanbul, Türkiye. Participants are classified into three groups according to predefined clinical criteria. The cervicogenic headache group includes individuals diagnosed by a physician according to the International Classification of Headache Disorders, 3rd edition. The chronic nonspecific neck pain group includes individuals with neck pain lasting at least 6 months and no headache. The healthy control group includes individuals without neck pain or headache. Participants receive no study intervention and complete one questionnaire-based and instrument-based assessment session.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults aged 25-60 years with cervicogenic headache diagnosed by a physician according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), and symptoms lasting at least 3 months. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.
Adults aged 25-60 years with chronic nonspecific neck pain lasting at least 6 months and no headache. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.
Adults aged 25-60 years with no neck pain or headaches. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.
Bilateral Upper Trapezius Muscle Stiffness
Upper trapezius muscle stiffness will be assessed bilaterally using the MyotonPRO device. Three consecutive measurements will be obtained at the midpoint between the C7 spinous process and the lateral border of the acromion. The mean of the three measurements will be used. Stiffness will be expressed in newtons per meter (N/m), with higher values indicating greater stiffness.
Time frame: During the single assessment session at enrollment
Bilateral Upper Trapezius Logarithmic Decrement
Upper trapezius logarithmic decrement will be assessed bilaterally using the MyotonPRO device at the same standardized measurement site. Three consecutive measurements will be obtained on each side, and their mean will be used. Logarithmic decrement is a dimensionless inverse indicator of tissue elasticity, with lower values indicating greater elasticity.
Time frame: During the single assessment session at enrollment
Bilateral Handgrip Strength
Bilateral handgrip strength will be measured using a Jamar Hydraulic Hand Dynamometer set to the second handle position. Participants will perform three maximal contractions with each hand in a standardized seated position. The highest value for each hand will be recorded in kilograms, with higher values indicating greater handgrip strength.
Time frame: During the single assessment session at enrollment
Bilateral Upper Trapezius Pressure Pain Threshold
Pressure pain threshold will be measured bilaterally over the upper trapezius using a handheld pressure algometer with a 1-cm² probe. The measurement site will be the midpoint between the C7 spinous process and the lateral border of the acromion. Pressure will gradually increase until the participant first reports pain. Values will be recorded in kg/cm², with higher values indicating a higher pressure pain threshold.
Time frame: During the single assessment session at enrollment
Bilateral Suboccipital Pressure Pain Threshold
Pressure pain threshold will be measured bilaterally over the suboccipital region using a handheld pressure algometer with a 1-cm² probe. The measurement site will be located 2 cm lateral to the C2 spinous process. Pressure will gradually increase until the participant first reports pain. Values will be recorded in kg/cm², with higher values indicating a higher pressure pain threshold.
Time frame: During the single assessment session at enrollment
Tragus-to-Wall Distance
Tragus-to-wall distance will be measured in millimeters using a tape measure. Participants will stand with their heels, sacrum, and thoracic spine resting comfortably against a wall while maintaining a natural head position. The distance between the wall and the tragus will be recorded. Greater distances indicate greater forward positioning of the head.
Time frame: During the single assessment session at enrollment
Craniovertebral Angle
The craniovertebral angle will be measured in degrees using a universal goniometer. The fulcrum will be positioned over the lateral projection of the C7 spinous process. The stationary arm will remain parallel to the floor, and the movable arm will point toward the tragus. Three measurements will be obtained, and their mean will be used. Smaller angles indicate greater forward head posture.
Time frame: During the single assessment session at enrollment
Plan to share: No — Individual participant data will not be shared. Study findings will be reported only in aggregate form through scientific publications and presentations.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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