A Phase 2/3 interventional study of Insulin eye drops and standard post-operative topical drops in Corneal Epithelial Wound Healing and Post Operative Pain, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Cairo University · Phase 2/3, Interventional, and Treatment
Among 132 studies in Pain, Postoperative by Cairo University — 32 open to participants now, 32 under way, 1 of them phase 3. Pain, Postoperative · Cairo University.
Among the 132 studies in Pain, Postoperative by Cairo University, this one is the 120th largest by enrollment of the 128 interventional ones that give a count, is one of 13 that started in 2023, is one of 3 in phase 2/3, and was the 130th registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
Browse Pain, Postoperative studies →32 of the 132 studies in Pain, Postoperative by Cairo University are open now, in 1 country. Recruiting first, the newest first:
Cairo University · Sites in Egypt
Cairo University · Sites in Egypt
Cairo University · Sites in Egypt
Cairo University · Sites in Egypt
Cairo University · Sites in Egypt
By country, each count listing its studies:
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
132 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 8 · Phase 2 7 · Phase 3 10 · Phase 4 15
First in 2014; this study’s year is marked. 13 started in 2023.
This study's enrollment of 24 is below the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Median enrollment 50 across the 128 interventional studies, 54 across the 4 observational. Of the 57 that completed or were terminated, 1 (2%) have results posted.
This tab as a report to print or save as PDF → With an account.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
7 of the studies in Pain, Postoperative by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07542795Cairo UniversityEvaluating The Use of CGF Plugs in Fresh Odontectomy Socket. | 2026-12-01 |
| NCT07618065Cairo University"Effect of Endermologie-Assisted Physiotherapy on Edema, Pain, and Functional Recovery After Liposuction for Lower-Limb Lipedema" | 2027-02-01 |
| NCT07446868Cairo UniversityUltrasound-Guided SPSIP Versus ESPB for Postoperative Pain After Modified Radical Mastectomy | 2027-03-01 |
| NCT07654556Cairo UniversityInvestigating the Analgesic Efficacy and Ease of Perfomance of Modified Throracoabdominal Plane Block and Comparing it With Erector Spinea Plane Block in Laparacopic Sleeve Gasterctomy Surgeries | 2027-03-30 |
| NCT07787221Cairo UniversityQL Block Versus EO Plane Block for Analgesia After Open Nephrectomy | 2027-04-01 |
Among the 132 studies in Pain, Postoperative by Cairo University, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking. The main questions it aimed to answer were:
Does topical insulin accelerate corneal epithelial healing after corneal collagen cross-linking? Does it affect post-operative pain?
Participants were all diagnosed as having bilateral progressive Keratoconus and were already scheduled for bilateral cross-linking:
Post-operatively, they were asked to apply insulin eye drops in one eye only (4 times daily) in addition to the prescribed routine post-operative treatment which was applied to both eyes.
They were also asked to come for follow-up visits on post-operative day 1,2,3,5 and 7 or until complete corneal wound healing.
The epithelial defect was measured in each eye and the participants were asked to report the degree of pain they felt in each eye at each visit until complete epithelial healing.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
- Patients above 18 years old diagnosed with bilateral progressive Keratoconus with central corneal thickness more than 400 microns at thinnest location.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
After bilateral sequential corneal cross-linking, each patient had one eye randomly assigned to receive insulin eye drops (4 times daily until complete epithelization) in addition to the standard post-operative treatment which was prescribed to both eyes (bandage contact lenses, Moxifloxacin 0.5% eye drops (Fortymox; Orchidia, Egypt), Tobramycin 0.3% + Dexamethasone 0.1% eye drops (Tobradex; Novartis, Switzerland), and a sodium hyaluronate/hydroxypropyl guar tear substitute (Systane Hydration; Alcon, USA), each four times daily). Insulin eye drops were prepared by adding 10 IU of human insulin (Actrapid; Novo Nordisk, Denmark) to 10 mL of Systane Hydration, yielding a 1 IU/mL solution. Patients were instructed to keep the drops refrigerated. Randomization was done using a coin toss (heads = right eye, tails = left eye) performed after eligibility confirmation, with allocation concealed using sequentially numbered, sealed envelopes prepared before recruitment.
Drug: Insulin eye drops
The other eye (control) of the same patient received the standard post-operative treatment only. This treatment included bandage contact lenses (1-Day Acuvue Moist, -0.25 D; Johnson \& Johnson Vision Care, USA), Moxifloxacin 0.5% eye drops (Fortymox; Orchidia, Egypt), Tobramycin 0.3% + Dexamethasone 0.1% eye drops (Tobradex; Novartis, Switzerland), and a sodium hyaluronate/hydroxypropyl guar tear substitute (Systane Hydration; Alcon, USA), each four times daily.
Drug: standard post-operative topical drops
A paired-eye interventional study exploring the effect of insulin eye drops on corneal epithelial wound healing after corneal collagen cross-linking in Keratoconus patients. Each patient served as their own control, where on eye received insulin eye drops post-operatively while the fellow eye (control) didn't.
The standard post-operative treatment prescribed to both eyes included Moxifloxacin 0.5% (Fortymox; Orchidia, Egypt), Tobramycin 0.3% + Dexamethasone 0.1% (Tobradex; Novartis, Switzerland), and a sodium hyaluronate/hydroxypropyl guar tear substitute (Systane Hydration; Alcon, USA), each four times daily.
Corneal epithelial wound healing
Patients were examined on post-operative days 1, 2, 3, 5, and 7, or until complete epithelization in both eyes. During these visits, the bandage contact lens were removed and the size of the epithelial defect was measured (guided by fluorescein staining) at its greatest dimension, along two perpendicular axes with a slit lamp micrometer. The healing rate, which is the speed at which the corneal epithelium heals, was assessed. It involved measuring the epithelial defect size changes over time by calculating the percentage of epithelial defect closure: (Original epithelial defect area - Current epithelial defect area)/(Current epithelial defect area) x 100. The percentage was calculated at each visit by the same examiner. New bandage contact lenses were applied after each examination until complete epithelial healing was achieved.
Time frame: 7 days or until complete epithelial healing
Post-operative pain
At each visit, assessment of patient comfort was evaluated for each eye separately by using the Verbal Rating Scale (VRS), which consists of a series of words commonly used to describe pain (0: no pain, 1: mild pain, 2: moderate pain, 3: severe pain, 4: very severe pain, 5: the worst pain ever), the patient was asked to describe the pain in each eye using these words.
Time frame: 7 days or until complete epithelial healing
Plan to share: No
No publications or documents are linked to this record.
Ran from Nov 2023 to primary completion in May 2025, 18 months.
Of 49 non-industry phase 2/3 interventional studies under Pain, Postoperative, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 41. This study's 18 months is close to that.
Counting every sponsor, half of 52 studies reached it within 17 months; a quarter within 10 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Insulin