An observational study in Breast Cancer - Female and Fertility, sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. Active, not recruiting at 3 sites in China. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine · Observational
This observational study is to learn about the fertility outcomes and decision after breast cancer diagnosis, and the current status of fertility consultation and decision support in young women diagnosed with breast cancer in China.
This study will include female patients aged 18-40 years who were diagnosed with breast cancer between January 2013 and December 2023 at one of three participating centres in China: the Second Affiliated Hospital of Zhejiang University School of Medicine, Jilin Cancer Hospital, and Hangzhou First People's Hospital.
Eligible patients must have complete medical records and no child before cancer diagnosis.
Patients with stage IV disease at diagnosis, those with pre-existing infertility factors, or those with other malignancies, will be excluded. Patients who decline to participate or cannot be contacted for follow-up will also be excluded.
Exclusion Criteria:
Patients diagnosed with breast cancer who had no live birth prior to diagnosis but had no live birth after diagnosis.
Other: No intervention (observational study)
Patients diagnosed with breast cancer who had no live birth prior to diagnosis but had at least one live birth after diagnosis.
Other: No intervention (observational study)
This is an observational study. Our study is based on the real-world conditions. We don't have any intervention.
Childbearing after breast cancer diagnosis
We will follow up with patients who had not given birth before their cancer diagnosis, to establish whether they had given birth by the end of follow-up. It will be assessed by patient self-report during follow-up and available medical records. The outcome will be recorded as a binary variable (yes/no).
Time frame: Up to 2026
Fertility preservation measures uptake
We will calculate the proportion of patients who underwent fertility preservation procedures in cases vs. controls.
Time frame: up to 2026
Multidisciplinary collaboration involvement
We will calculate the proportion of patients with multidisciplinary team discussion or referral involving reproductive medicine, gynecology, or fertility specialists.
Time frame: up to 2026
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital, Zhejiang University, School of Medicine