An observational study in Attention-Deficit/Hyperactivity Disorder (ADHD), sponsored by Akdeniz University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 10 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by Akdeniz University · Observational
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Among 45 studies in Attention Deficit Disorder with Hyperactivity with a site in Turkey — 5 open to participants now, 7 under way, none of them phase 3. Attention Deficit Disorder with Hyperactivity · Turkey.
Among the 45 studies in Attention Deficit Disorder with Hyperactivity with a site in Turkey, this one is the 11th largest by planned enrollment of the 17 observational ones that give a count, is one of 2 that started in 2026, is one of 17 observational ones, and was the 44th registered.
1,817 studies on the registry are indexed under Attention Deficit Disorder with Hyperactivity; 295 are open to participants now.
Browse Attention Deficit Disorder with Hyperactivity studies →5 of the 45 studies in Attention Deficit Disorder with Hyperactivity with a site in Turkey are open now. Recruiting first, the newest first:
Sultan 1. Murat State Hospital · Sites in Turkey
Ages 18–50 · Women only
Biruni University · Sites in Turkey
Ages 10–14 · Healthy volunteers
Medipol University · Sites in Turkey
Ages 18–40 · Healthy volunteers
Istanbul University - Cerrahpasa · Sites in Turkey
Ages 9–12
Akdeniz University · Sites in Turkey
Ages 6–15 · Healthy volunteers
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 201 Attention Deficit Disorder with Hyperactivity studies recruiting now, 27 (13%) set no upper age limit and 169 (84%) stop at 75 or younger; 141 take children under 18; 55 take healthy volunteers.
This study: 10 Years to 18 Years · all sexes · healthy volunteers too.
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45 studies; the count open now beside each. This study's row is marked.
First in 2007; this study’s year is marked. 2 started in 2026.
This study's planned enrollment of 80 is below the median of 127 across 329 observational studies indexed under Attention Deficit Disorder with Hyperactivity.
Median enrollment 47 across the 28 interventional studies, 85 across the 17 observational. Of the 38 that completed or were terminated, 3 (8%) have results posted.
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1 of 45 have an industry lead sponsor. The 10 most frequent:
Akdeniz University is the lead sponsor of 298 studies on the registry; 62 are open to participants now.
Akdeniz University has 4 studies filed under Attention Deficit Disorder with Hyperactivity — fewer than ten, so there is no comparison to draw.
1 of the studies in Attention Deficit Disorder with Hyperactivity with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07800117Akdeniz UniversityInvestigation of the Association of Multimodal Neuroimaging and Peripheral Biomarkers With Executive Functions and Emotional Regulation in Adolescents With Attention-Deficit/Hyperactivity Disorder | 2026-12-01 |
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Among the 45 studies in Attention Deficit Disorder with Hyperactivity with a site in Turkey, from their registry updates:
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The purpose of this observational study is to investigate the relationships among resting-state brain connectivity, peripheral blood biomarkers, executive functions, and emotional regulation in adolescents with attention-deficit/hyperactivity disorder (ADHD). The study will include 40 adolescents aged 10 to 18 years with ADHD and 40 age- and sex-matched healthy controls. Participants will undergo clinical and psychological assessments, resting-state functional magnetic resonance imaging, and blood sampling. Serum levels of BDNF, cortisol, IL-1α, IFN-γ, TNF-α, and IL-6 will be measured. The study will examine whether differences in brain connectivity and biomarker levels are associated with executive functioning and emotional regulation.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by difficulties in attention, hyperactivity, and impulsivity. Although alterations in neural networks and peripheral biological processes have been investigated separately, the relationships among functional brain connectivity, peripheral biomarkers, executive functions, and emotional regulation in adolescents with ADHD remain incompletely understood.
The primary aim of this study is to investigate the relationships among resting-state functional brain connectivity, peripheral serum biomarkers, executive functions, and emotional regulation in adolescents with ADHD and to compare these findings with those of healthy controls. The study will focus particularly on resting-state functional connectivity within and between brain networks, including the default mode network (DMN), executive control network (ECN), and salience network (SN).
The study will include adolescents aged 10 to 18 years with ADHD and age- and sex-matched healthy controls. Participants will undergo standardized clinical and psychological assessments, resting-state functional magnetic resonance imaging (fMRI), and peripheral blood sampling. Serum concentrations of brain-derived neurotrophic factor (BDNF), cortisol, interleukin-1 alpha (IL-1α), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) will be measured using enzyme-linked immunosorbent assay (ELISA).
Executive functioning, emotional regulation, behavioral characteristics, and clinical symptoms will be assessed using standardized clinical and behavioral assessment instruments. Resting-state fMRI data will be processed using standard preprocessing procedures, including motion correction, coregistration, normalization, smoothing, denoising, and band-pass filtering. Functional connectivity analyses will be conducted using independent component analysis and/or seed-based correlation approaches.
The study will examine whether alterations in resting-state functional connectivity and peripheral biomarker levels differ between adolescents with ADHD and healthy controls and whether these biological measures are associated with executive functioning, emotional regulation, and clinical characteristics. Associations among functional connectivity measures, serum biomarkers, and behavioral and clinical scores will also be investigated.
The study is designed to contribute to a more comprehensive understanding of the neurobiological mechanisms underlying ADHD in adolescence by integrating neuroimaging, peripheral biological, and behavioral measures.
The study population will consist of 80 participants aged 10-18 years, including 40 adolescents diagnosed with attention-deficit/hyperactivity disorder (ADHD) according to DSM-5 criteria and 40 healthy controls. Participants in the ADHD group will be recruited from the Child and Adolescent Psychiatry outpatient clinic of Akdeniz University Hospital. Healthy controls will be recruited from the General Pediatrics outpatient clinic of Akdeniz University Hospital. The groups will be matched for sex. All participants will have clinically normal intellectual capacity (IQ >80) and be predominantly right-handed. Participants with acute or chronic inflammatory diseases or other specified exclusion criteria will not be included.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Healthy Control Group:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adolescents aged 10 to 18 years (including ages 10 and 18) who have been diagnosed with attention-deficit/hyperactivity disorder (ADHD) according to DSM-5 criteria and who are not receiving any medication treatment will be included in this group. Participants will have clinically normal intellectual capacity (IQ \>80), be predominantly right-handed, and have no acute or chronic inflammatory disease. A total of 40 participants with ADHD will be included. Participants will undergo clinical and neuropsychological assessments, resting-state functional magnetic resonance imaging, and venous blood sampling for serum biomarker analysis.
Other: No Intervention
Healthy adolescents aged 10 to 18 years (including ages 10 and 18) without a psychiatric diagnosis according to DSM-5 criteria will be included in this group. Participants will have clinically normal intellectual capacity (IQ \>80), be predominantly right-handed, and have no acute or chronic inflammatory disease. Participants will be age- and sex-matched with the ADHD group. A total of 40 healthy control participants will be included. Participants will undergo clinical and neuropsychological assessments, resting-state functional magnetic resonance imaging, and venous blood sampling for serum biomarker analysis. The same exclusion criteria applied to the ADHD group will also apply to the healthy control group.
Other: No Intervention
This is an observational study. No intervention or treatment is assigned to participants. Participants are assessed using clinical and neuropsychological assessments, resting-state functional magnetic resonance imaging, and peripheral blood biomarker measurements.
Resting-State Functional Connectivity Within and Between the Default Mode Network and Other Brain Networks
Resting-state functional magnetic resonance imaging (fMRI) will be used to assess functional connectivity within the Default Mode Network (DMN) and between the DMN and other brain networks. Functional connectivity measures will be compared between adolescents with attention-deficit/hyperactivity disorder and healthy controls.
Time frame: At the baseline assessment
Serum BDNF, Cortisol, IL-1α, IL-6, TNF-α, and IFN-γ Levels
Serum levels of brain-derived neurotrophic factor (BDNF), cortisol, interleukin-1 alpha (IL-1α), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) will be measured and compared between adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls.
Time frame: At the baseline assessment
Executive Functioning Measured by the Behavior Rating Inventory of Executive Function (BRIEF)
Executive functioning will be assessed using the Behavior Rating Inventory of Executive Function (BRIEF). Executive functioning scores will be examined in relation to resting-state functional connectivity and serum biomarker levels.
Time frame: At the baseline assessment
Emotion Regulation Difficulties Measured by the Difficulties in Emotion Regulation Scale
Emotion regulation difficulties will be assessed using the Difficulties in Emotion Regulation Scale. Scores will be examined in relation to resting-state functional connectivity and serum biomarker levels.
Time frame: At the baseline assessment
Plan to share: Undecided
No publications or documents are linked to this record.
Started Mar 2026 (actual). Primary completion is estimated for Dec 2026, 9 months after the start.
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This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Attention Deficit Disorder with Hyperactivity →