An observational study in Cervical Radiculopathy and Cervical Disc Herniation, sponsored by Marmara University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-10-30.
Sponsored by Marmara University · Observational
Among 18 studies in Radiculopathy by Marmara University — 8 open to participants now, 10 under way, none of them phase 3. Radiculopathy · Marmara University.
Among the 18 studies in Radiculopathy by Marmara University, this one is the 5th largest by enrollment of the 12 observational ones, is one of 5 that started in 2026, is one of 12 observational ones, and was the 16th registered.
483 studies on the registry are indexed under Radiculopathy; 145 are open to participants now.
This study's enrollment of 123 is above the median of 100 across 95 observational studies indexed under Radiculopathy.
Browse Radiculopathy studies →8 of the 18 studies in Radiculopathy by Marmara University are open now, in 1 country. Each count lists the studies.
Of the 80 Radiculopathy studies recruiting now, 23 (29%) set no upper age limit and 49 (61%) stop at 75 or younger; 3 take children under 18; 7 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →18 studies; the count open now beside each. This study's row is marked.
First in 2016; this study’s year is marked. 5 started in 2026.
Median enrollment 61 across the 6 interventional studies, 120 across the 12 observational. Of the 6 that completed or were terminated, 0 (0%) have results posted.
Marmara University is the lead sponsor of 599 studies on the registry; 138 are open to participants now.
3 of the studies in Radiculopathy by Marmara University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07776431Marmara UniversityElectrophysiological Predictors of Cervical DRG Pulsed Radiofrequency Outcomes | 2026-11 |
| NCT07799142Marmara UniversityFemoral Stretch Test in L2-L4 Lumbar Radiculopathy | 2027-03 |
| NCT07828132Marmara UniversityEffect of Alexithymia on Treatment Response to Transforaminal Epidural Steroid Injections in Chronic Low Back Pain | 2027-09 |
Among the 18 studies in Radiculopathy by Marmara University, from their registry updates:
This single-center observational comparative cohort study evaluates clinical outcomes following two cervical interlaminar epidural steroid injection protocols used in routine care for chronic cervical radicular pain due to cervical disc herniation. Patients underwent the procedure between January 1 and July 1, 2026 and were classified according to the injectate already administered: lidocaine, dexamethasone, and normal saline, or lidocaine, dexamethasone, and magnesium sulfate. Treatment selection was determined by the treating physician during routine clinical care and was not assigned by the investigators. Data available at ethics approval were obtained retrospectively from clinical records. For patients whose scheduled routine follow-up had not yet occurred, follow-up outcomes were recorded prospectively after ethics approval. No research-specific treatment, additional visit, additional test, or modification of routine care was undertaken. Pain, neck-related disability, and health-related quality of life were evaluated using the Numeric Rating Scale, Neck Disability Index, and Short Form-12 over three months.
Eligible adults aged 18 to 75 years who underwent cervical interlaminar epidural steroid injection for chronic cervical radicular pain associated with cervical disc herniation between January 1 and July 1, 2026 were included in this single-center observational comparative cohort. Patients were classified according to the treatment received in routine clinical care. Both protocols contained lidocaine and dexamethasone; the magnesium sulfate protocol replaced the normal saline component with magnesium sulfate. The procedure and injectate were selected before study-specific prospective follow-up, based on the treating physician's clinical decision. They were not assigned or modified by the investigators.
The study combines retrospective review of existing records and prospective recording of remaining routine follow-up assessments after ethics approval. No additional intervention, assessment, test, medication, or follow-up visit was introduced for the study. Numeric Rating Scale scores were assessed before the procedure and at 1 hour, 3 weeks, and 3 months. Neck Disability Index and Short Form-12 physical and mental component scores were assessed at baseline, 3 weeks, and 3 months. The registered primary outcome remains change in Numeric Rating Scale score from baseline to 3 months. Other pain time points and changes in neck-related disability and quality of life remain secondary outcomes. The study evaluates associations between the protocol received and clinical outcomes; treatment allocation was not randomized.
Adults aged 18 to 75 years who underwent cervical interlaminar epidural steroid injection for chronic cervical radicular pain associated with cervical disc herniation at the Pain Medicine Division of Marmara University Pendik Training and Research Hospital between January 1 and July 1, 2026. Eligible patients with the required baseline and routine follow-up data form the comparative cohort. Existing data were reviewed retrospectively, and routine follow-up assessments not yet completed at ethics approval were recorded prospectively thereafter.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants who received a cervical interlaminar epidural steroid injection containing lidocaine, dexamethasone, and normal saline as part of routine clinical care.
Drug: Normal Saline
Participants who received a cervical interlaminar epidural steroid injection containing lidocaine, dexamethasone, and magnesium sulfate as part of routine clinical care.
Drug: Magnesium Sulfate
Magnesium sulfate was administered as an adjunct to lidocaine and dexamethasone during cervical interlaminar epidural steroid injection as part of routine clinical care. Treatment was not assigned by the investigators.
Normal saline was administered with lidocaine and dexamethasone during cervical interlaminar epidural steroid injection as part of the standard routine clinical protocol. Treatment was not assigned by the investigators.
Change in Pain Intensity From Baseline to 3 Months
Pain intensity is assessed using the Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. The change in pain intensity from baseline to 3 months after the procedure will be compared between the two cohorts. A greater reduction in score indicates greater improvement.
Time frame: Baseline and 3 months after the procedure
Early Change in Pain Intensity
Pain intensity is assessed using the Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. The change from baseline to 1 hour after the procedure will be compared between the two cohorts. A greater reduction indicates greater improvement.
Time frame: Baseline and 1 hour after the procedure
Change in Pain Intensity at 3 Weeks
Pain intensity is assessed using the Numeric Rating Scale, ranging from 0 to 10. The change from baseline to 3 weeks after the procedure will be compared between the two cohorts. A greater reduction indicates greater improvement.
Time frame: Baseline and 3 weeks after the procedure
Change in Neck-Related Disability
Neck-related disability is assessed using the 10-item Neck Disability Index. Raw item scores total 0 to 50 and can be expressed on a 0 to 100 scale by multiplying by two. For analysis, both cohorts are harmonized to the 0 to 100 scale, with higher scores indicating greater disability. Changes from baseline at 3 weeks and 3 months are compared between cohorts.
Time frame: Baseline, 3 weeks, and 3 months after the procedure
Change in SF-12 Physical Component Summary Score
Physical health-related quality of life is assessed using the Physical Component Summary score of the 12-Item Short Form Health Survey. Scores are standardized, with higher scores indicating better physical health-related quality of life. Changes from baseline will be compared between the two cohorts.
Time frame: Baseline, 3 weeks, and 3 months after the procedure
Change in SF-12 Mental Component Summary Score
Mental health-related quality of life is assessed using the Mental Component Summary score of the 12-Item Short Form Health Survey. Scores are standardized, with higher scores indicating better mental health-related quality of life. Changes from baseline will be compared between the two cohorts.
Time frame: Baseline, 3 weeks, and 3 months after the procedure
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2026 to primary completion in Oct 2026, 9 months.
Of 40 observational studies under Radiculopathy, half reached primary completion within 75 months of starting (the median), counting those still running; a quarter within 26 and three quarters within 95. This study's 9 months is below that.
Completion moved once since we started tracking on Sep 25, 2026: Dec 2026 → Oct 2026, on Oct 30, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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