ClinicalTrials.gg
CompletedNCT07765290RWT-THYROIDUpdated Oct 19, 2026

Thyroid Hormone Responses to Repeated Wingate Exercise Versus a Non-Exercising Comparison Group

An interventional study of Repeated Wingate Exercise in Exercise and Thyroid Function, sponsored by Inonu University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-19.

Sponsored by Inonu University · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 2 years after the study started (first participant enrolled Aug 2024, registered Aug 2026).
Updated Oct 19, 2026Start date movedPrimary completion moved+1 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Non-randomized
Ages
18 Years to 25 Years
Sex
Male
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 20 studies in Motor Activity by Inonu University — 6 open to participants now, 8 under way, none of them phase 3. Motor Activity · Inonu University.

Enrollment
8th of 19
40 · median 40
Started
2024
with 3 others
No phase
19 of 20
6 open now
Registered
19th of 20
by date

Among the 20 studies in Motor Activity by Inonu University, this one is the 8th largest by enrollment of the 19 interventional ones that give a count, is one of 4 that started in 2024, is one of 19 with no phase, and was the 19th registered.

Motor Activity

9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.

Browse Motor Activity studies →

Open to participants now

6 of the 20 studies in Motor Activity by Inonu University are open now, in 1 country. Recruiting first, the newest first:

1 more — sign in →

By country, each count listing its studies:

All 6 open studies →

Where they have run

Who these studies take

Of the 1,201 Motor Activity studies recruiting now, 517 (43%) set no upper age limit and 535 (45%) stop at 75 or younger; 180 take children under 18; 420 take healthy volunteers.

This study: 18 Years to 25 Years · male · healthy volunteers too.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 20 studies in Motor Activity by Inonu University, or all of them as a file.
02

Study summary

This two-group, non-randomized study investigated the acute effects of repeated Wingate exercise on free thyroid hormone concentrations in male amateur soccer players. Twenty healthy male amateur soccer players completed a standardized repeated Wingate exercise protocol, and a separate group of twenty male amateur soccer players provided two morning blood samples without exercising. Blood samples were collected immediately before and immediately after the exercise session or the resting interval to determine free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) concentrations. Including a non-exercising comparison group allows the observed changes to be evaluated against the change expected across a comparable interval in the absence of exercise.

Read the detailed description

High-intensity anaerobic exercise induces acute physiological and endocrine responses that contribute to metabolic regulation and athletic performance. Thyroid hormones, including free triiodothyronine (fT3) and free thyroxine (fT4), play essential roles in energy metabolism, oxygen consumption, and exercise adaptation. However, the immediate effects of repeated supramaximal exercise on thyroid hormone responses remain insufficiently understood, and most previous reports lack any non-exercising comparison condition, so observed changes cannot be separated from time of day, posture, repeated venipuncture, or routine analytical variation.

This two-group non-randomized study was designed to compare the acute effects of repeated Wingate exercise on free thyroid hormone concentrations against a non-exercising comparison group. Twenty healthy male amateur soccer players completed a standardized repeated Wingate exercise protocol under controlled laboratory conditions, consisting of six 30-second maximal bouts at 7.5% of body mass separated by 4 minutes of passive recovery. A comparison group of twenty male amateur soccer players provided two venous blood samples on one morning without performing any exercise between them. Venous blood samples were collected immediately before and immediately after the exercise session or the resting interval to determine free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) concentrations. Hormone analyses were performed using standardized laboratory procedures.

The two groups were recruited and sampled in different periods rather than concurrently, and participants were therefore not randomly allocated. The primary objective was to determine whether the change in circulating free thyroid hormone concentrations around a repeated Wingate session differs from the change observed across a comparable resting interval.

03

Conditions studied

  • Exercise
  • Thyroid Function

Browse trials for

Keywords

  • free triiodothyronine
  • free thyroxine
  • thyroid-stimulating hormone
  • high-intensity interval exercise
  • Wingate anaerobic test
  • soccer
  • acute endocrine response
04

Who can participate

Ages eligible
18 Years to 25 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male amateur soccer players.
  • Age between 18 and 25 years.
  • At least 6 years of licensed soccer experience.
  • Actively participating in amateur soccer training.
  • Apparently healthy and free from acute or chronic disease on medical history review.
  • Willingness to participate and provision of written .

Exclusion criteria

Exclusion Criteria:

  • Acute illness or musculoskeletal injury at the time of testing.
  • Neurological, auditory, visual or vestibular disorder.
  • Reduced physical capacity due to injury, or a sedentary lifestyle.
  • History of nutritional or pharmacological ergogenic aid use.
  • Failure to complete the study procedures or all required blood sample collections.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Repeated Wingate Exercise

    Participants completed a standardized repeated Wingate exercise protocol under laboratory conditions. Blood samples were collected immediately before and immediately after the exercise session to assess acute changes in serum free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH).

    Behavioral: Repeated Wingate Exercise

  • No intervention
    Comparison group

    Participants provided two venous blood samples on one morning and performed no exercise between the two samples. Serum free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were measured in both samples.

Interventions

  • BehavioralRepeated Wingate Exercise

    Participants completed a standardized repeated Wingate exercise protocol under controlled laboratory conditions to investigate the acute effects of high-intensity anaerobic exercise on thyroid hormone responses. Venous blood samples were collected immediately before and immediately after the exercise session to measure serum free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) concentrations.

    Also known as: Repeated Wingate Test

06

What researchers measure

Primary outcomes

  1. Change in Serum Free Thyroid Hormone Concentrations (fT3, fT4, and TSH)

    The primary outcome was the within-participant change in serum free thyroid hormone concentrations, including free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH), measured immediately before and immediately after the repeated Wingate exercise protocol in the exercise group and across a comparable resting interval in the comparison group. Change scores were compared between groups.

    Time frame: Immediately before and immediately after the repeated Wingate exercise session or the resting interval

07

Study locations

1 site
  • Exercise Physiology Laboratory, Faculty of Sport Sciences, Karabuk University
    Karabük, Karabük Province 78050, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: Yes — De-identified participant-level data and analysis code are available from the corresponding author on reasonable request, subject to applicable ethics, participant-consent, and institutional requirements.

Supporting information: Analytic code

Time frame: Data will be available from the date of publication, with no planned end date.

Access criteria: Requests should be directed to the corresponding author. Data will be shared with researchers who provide a methodologically sound proposal, subject to applicable ethics approval, participant-consent restrictions, and institutional requirements. A data-use agreement may be required.

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Aug 2024 to primary completion in Aug 2024, 0 months.

Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's 0 months is below that.

Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 19, 2026: start Jun 2023 → Aug 2024, primary completion Jun 2023 → Aug 2024 and completion Jun 2023 → Aug 2024.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Aug 11, 2026
First posted
Aug 14, 2026
StartActual
Aug 1, 2024was Jun 2023
Primary completionActual
Aug 27, 2024was Jun 2023
CompletionActual
Aug 27, 2024was Jun 2023
Last update
Oct 19, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Start date
Jun 15, 2023→Aug 1, 2024
Oct 19, 2026
Primary completion
Jun 30, 2023→Aug 27, 2024
Oct 19, 2026
Study completion
Jun 30, 2023→Aug 27, 2024
Oct 19, 2026
Show all 1 update
  1. Oct 19, 2026
    Start date Jun 15, 2023→Aug 1, 2024
    Primary completion Jun 30, 2023→Aug 27, 2024
    Study completion Jun 30, 2023→Aug 27, 2024
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07765290
Lead sponsor
Inonu University
Responsible party
Assoc. Prof. Dr. Özgür EKEN (Assoc. Prof.Dr., Inonu University) — Principal investigator
First posted
Aug 14, 2026
Start date
Aug 1, 2024
Primary completion
Aug 27, 2024
Completion
Aug 27, 2024
Last update
Oct 19, 2026

Study contacts

Özgür EKEN, PhD
principal investigator · Inonu University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion