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Not yet recruitingNCT07921498ISOK-WAnTUpdated Nov 10, 2026

Isokinetic Knee Strength, Bilateral Muscle Balance, and Anaerobic Performance in Adolescent Athletes

An observational study in Isokinetic Knee Strength, Hamsting-to-Quadriceps Strength Ratio and Anaerobic Performance, sponsored by Inonu University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to male participants aged 15 Years to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-10.

Sponsored by Inonu University · Observational

Updated Nov 6, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
21
Ages
15 Years to 16 Years
Sex
Male
01

Study summary

This study looks at how strong the knee muscles are in adolescent athletes and how this strength relates to short-term, high-intensity (anaerobic) performance. Strong, well-balanced thigh muscles may help athletes produce more power during sport movements, but this has not been studied well in teenagers. Male athletes aged 15-16 years will be measured on two separate days. On the first day, their height and body weight will be measured and the strength of the muscles at the front (quadriceps) and back (hamstrings) of both thighs will be tested on a special strength-testing machine. On the second day, they will do a 30-second all-out cycling test to measure anaerobic power. The study will compare the right and left legs and will examine whether knee muscle strength and the balance between the front and back thigh muscles are linked to power output during the cycling test. No treatment or intervention will be given. The results may help coaches and sports scientists understand the physical development of adolescent athletes.

Read the detailed description

Lower-limb strength and anaerobic power are important parts of the physical profile of adolescent athletes in high-intensity sports such as wrestling. Isokinetic dynamometry allows knee extensor (quadriceps) and flexor (hamstring) strength and the balance between these muscle groups to be measured objectively, while the 30-second Wingate Anaerobic Test (WAnT) is a widely used laboratory test of anaerobic performance. Evidence on how these measures relate to each other in adolescent athletes is limited.

This is a cross-sectional, correlational observational study. Twenty-one male adolescent athletes aged 15-16 years will be recruited in Malatya, Turkey. Written informed consent will be obtained from parents or legal guardians, and assent from participants. Testing will take place on two separate days to limit fatigue. Participants will avoid heavy exercise for 48 hours and caffeine for 12 hours before testing.

Day 1: Height and body mass are measured and body mass index is calculated. Concentric knee extension and flexion are then tested bilaterally on a HUMAC NORM isokinetic dynamometer at 60, 120 and 180 degrees per second (three practice repetitions followed by five maximal repetitions at each speed; 45 seconds of rest between speeds and 10 minutes between limbs). Peak torque is recorded for the quadriceps and hamstrings of each limb, and the conventional hamstring-to-quadriceps (H/Q) ratio is calculated.

Day 2: Participants complete a 30-second WAnT on a mechanically braked cycle ergometer (Monark 874E) with a braking load of 0.075 kg per kg of body mass, after a standardized warm-up. Peak power, mean power and fatigue index are recorded.

Differences between the right and left limbs will be examined with paired-samples t-tests (with 95% confidence intervals and Cohen's dz). Associations between isokinetic variables and WAnT outcomes will be examined with Pearson correlation. The sample size (minimum 19) was calculated with G*Power for a correlation of r = 0.60 (alpha = 0.05, power = 0.80); 21 participants are planned to allow for possible data loss.

02

Conditions studied

  • Isokinetic Knee Strength
  • Hamsting-to-Quadriceps Strength Ratio
  • Anaerobic Performance

Keywords

  • adolescent athletes
  • isokinetic dynamometry
  • knee strength
  • hamstring-to-quadriceps ratio
  • muscle balance
  • Wingate Anaerobic Test
  • anaerobic performance
03

In context

Lead sponsor

Inonu University is the lead sponsor of 394 studies on the registry; 95 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
15 Years to 16 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Male adolescent athletes aged 15-16 years who actively wrestle and train regularly in Malatya, Turkey. Participants are healthy athletes recruited from local clubs on a voluntary basis.

Eligibility criteria

Inclusion Criteria:

  • Actively practicing wrestling in Malatya, Turkey
  • Male, aged 15-16 years
  • At least 2 years of regular training (at least 2 days per week)
  • No lower-extremity injury or surgery in the last 6 months
  • No musculoskeletal, cardiometabolic, or neurological condition that could prevent testing
  • Willing to participate in all planned tests
  • Written signed by parent or legal guardian, and assent from the participant

Exclusion Criteria: * Younger than 15 or older than 16 years

  • Lower-extremity injury or surgery within the last 6 months
  • Musculoskeletal, cardiometabolic, or neurological condition that could prevent testing
  • Open wound, varicose veins, acute inflammation, or history of thrombosis
  • Regular use of analgesic or anti-inflammatory medication or ergogenic supplements in the last 3 months
  • Unable to attend all planned testing sessions
  • Unwilling to follow the pre-test rules (no heavy exercise for 48 hours, no caffeine for 12 hours, usual training and diet)
  • Withdrawal during the study due to non-compliance, incomplete sessions, serious injury or illness, or participant request
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
21 participants (estimated)
Patient registry
No

Groups and cohorts

  • Adolescent Athletes

    Male adolescent athletes aged 15-16 years who regularly train and compete. All participants complete anthropometric measurements, bilateral isokinetic knee strength testing, and the Wingate Anaerobic Test on separate days.

    Diagnostic Test: Isokinetic Knee Strength Testing · Diagnostic Test: Wingate Anaerobic Test

Interventions

  • Diagnostic testIsokinetic Knee Strength Testing

    Bilateral concentric knee extension and flexion tested on an isokinetic dynamometer at 60, 120, and 180 degrees per second. Peak torque and the conventional hamstring-to-quadriceps ratio are recorded.

  • Diagnostic testWingate Anaerobic Test

    A 30-second all-out cycling test on a mechanically braked cycle ergometer with a braking load of 0.075 kg per kg of body mass. Peak power, mean power, and fatigue index are recorded.

    Also known as: WAnT

06

What researchers measure

Primary outcomes

  1. Isokinetic Peak Torque of the Knee Extensors and Flexors

    Peak torque (N·m) of the quadriceps and hamstrings, measured separately for the right and left limbs at 60, 120, and 180 degrees per second on an isokinetic dynamometer (highest value across five maximal concentric repetitions). Right-to-left differences and associations with Wingate Anaerobic Test outcomes are analyzed.

    Time frame: Day 1 of testing (single measurement session)

  2. Wingate Anaerobic Test Peak Power

    Highest power output (W) achieved during the 30-second Wingate Anaerobic Test performed on a mechanically braked cycle ergometer with a braking load of 0.075 kg per kg of body mass.

    Time frame: Day 2 of testing (single measurement session)

Secondary outcomes

  1. Conventional Hamstring-to-Quadriceps (H/Q) Strength Ratio

    Concentric hamstring peak torque divided by quadriceps peak torque, multiplied by 100 (%), calculated for each limb at 60, 120, and 180 degrees per second.

    Time frame: Day 1 of testing

  2. Wingate Anaerobic Test Mean Power

    Average power output (W) maintained across the 30-second Wingate Anaerobic Test.

    Time frame: Day 2 of testing

  3. Wingate Anaerobic Test Fatigue Index

    Percentage decline from peak power to the lowest power output during the test: \[(peak power - minimum power) / peak power\] × 100.

    Time frame: Day 2 of testing

07

Study locations

1 site
  • Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Inonu University,
    Malatya, Malatya 44280, Turkey (Türkiye)
08

References and documents

Publications

  • Iossifidou A, Baltzopoulos V, Giakas G. Isokinetic knee extension and vertical jumping: are they related? J Sports Sci. 2005 Oct;23(10):1121-7. doi: 10.1080/02640410500128189. PubMed 16194988 ↗
  • Chaabene H, Negra Y, Bouguezzi R, Mkaouer B, Franchini E, Julio U, Hachana Y. Physical and Physiological Attributes of Wrestlers: An Update. J Strength Cond Res. 2017 May;31(5):1411-1442. doi: 10.1519/JSC.0000000000001738. PubMed 28030533 ↗
  • Alemdaroglu U. The relationship between muscle strength, anaerobic performance, agility, sprint ability and vertical jump performance in professional basketball players. J Hum Kinet. 2012 Mar;31:149-58. doi: 10.2478/v10078-012-0016-6. Epub 2012 Apr 3. PubMed 23486566 ↗
  • Aagaard P, Simonsen EB, Magnusson SP, Larsson B, Dyhre-Poulsen P. A new concept for isokinetic hamstring: quadriceps muscle strength ratio. Am J Sports Med. 1998 Mar-Apr;26(2):231-7. doi: 10.1177/03635465980260021201. PubMed 9548116 ↗

Individual participant data

Plan to share: No — Individual participant data will not be shared, because participants are minors and the consent forms state that data will be used only for the purposes of this research and kept confidential. Aggregate results will be published.

09

Timeline

2 registry updates since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Dec 2026; primary completion for Jan 2027, 1 month later.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 2, 2026
First posted
Nov 6, 2026
StartEst.
Dec 28, 2026
Primary completionEst.
Jan 28, 2027
CompletionEst.
Jan 28, 2027
Last update
Nov 10, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 6, 2026
Show all 2 updates
  1. Nov 10, 2026
    Minor edits only
    + 2 other changes: conditions and references
  2. Nov 6, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07921498
Lead sponsor
Inonu University
Responsible party
Assoc. Prof. Dr. Özgür EKEN (Associate Professor, Inonu University) — Principal investigator
First posted
Nov 6, 2026
Start date
Dec 28, 2026 (estimated)
Primary completion
Jan 28, 2027 (estimated)
Completion
Jan 28, 2027 (estimated)
Last update
Nov 10, 2026

Study contacts

Ozgur Eken, PhD, Associate Professor
Contact
ozgur.eken@inonu.edu.tr
+90 553 213 27 95
Denizhan Çalışkan, Dr.
Contact
denizhancaliskann@gmail.com
+90 539 879 64 59
Özgür Eken, PhD, Assoc. Prof.
principal investigator · Inonu University, Faculty of Sport Sciences
Denizhan Çalışkan, Dr.
study director · Eskisehir Provincial Directorate of Youth and Sports, Eskisehir, Türkiye

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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