ClinicalTrials.gg
RecruitingNCT07704970Updated Sep 25, 2026

QLESP Block for Pain Control in Robotic Partial Nephrectomy

An interventional study of ropivacaine (local infiltration) and ropivacaine in Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain and Nerve Block, sponsored by Huazhong University of Science and Technology. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-25.

Sponsored by Huazhong University of Science and Technology · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Sep 2026; still recruiting 1 month later.
Updated Sep 25, 2026Now RecruitingSite recruiting status changed+1 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults. The main questions it aims to answer are:

  1. Does QLESP reduce the total amount of opioid pain medicine participants need in the first 48 hours after surgery?
  2. Does QLESP lower pain scores and improve recovery quality after surgery? Researchers will compare participants who receive QLESP block to participants who receive the same numbing medicine injected only at the surgical wound sites.

Participants will:

  1. Be randomly assigned to receive either QLESP or local wound injection before surgery.
  2. Have a patient-controlled pain pump for 48 hours after surgery.
  3. Complete pain scores and recovery quality questionnaires at 2, 6, 12, 24, 48, and 72 hours after surgery.
  4. Be followed until hospital discharge.
02

Conditions studied

  • Renal Cell Carcinoma (Kidney Cancer)
  • Postoperative Pain
  • Nerve Block

Keywords

  • Quadratus Lumborum Block
  • Erector Spinae Plane Block
  • Robot-Assisted Partial Nephrectomy
  • Postoperative Pain
  • Enhanced Recovery After Surgery
03

In context

Carcinoma, Renal Cell

2,037 studies on the registry are indexed under Carcinoma, Renal Cell; 395 are open to participants now.

This study's planned enrollment of 120 is above the median of 43 across 1,564 interventional studies indexed under Carcinoma, Renal Cell.

Browse Carcinoma, Renal Cell studies →

Lead sponsor

Huazhong University of Science and Technology is the lead sponsor of 247 studies on the registry; 62 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Aged 18 to 75 years
  • Scheduled for elective robot-assisted partial nephrectomy (RAPN)
  • (ASA) physical status I to III
  • (BMI) 18 to 35 kg/m²
  • Voluntarily signed form Able to understand pain scoring and use of patient-controlled analgesia (PCA)

Exclusion criteria

Exclusion Criteria:

  • Language, communication, or comprehension barriers
  • Infection at the intended puncture site
  • Coagulopathy or bleeding diathesis
  • Known allergy or to local anesthetics or opioids
  • Use of analgesic medications within the past 3 months
  • Peripheral neuropathy
  • Severe cardiac, hepatic, or renal dysfunction
  • Pregnancy or breastfeeding
  • Refusal to participate in the study
Terms in these criteria, in plain language(4)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

ASA physical status

The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
120 participants (estimated)

Study arms

  • Experimental
    QLESP Group

    Participants receive ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL in the erector spinae fascial plane and 15 mL in the quadratus lumborum-psoas major interfascial plane) after induction of general anesthesia.

    Drug: ropivacaine

  • Active comparator
    Control Group

    Participants receive local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery.

    Drug: ropivacaine (local infiltration)

Interventions

  • Ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL injected between the erector spinae muscle and the transverse process at L2 level, followed by 15 mL injected between the quadratus lumborum and psoas major muscles) after induction of general anesthesia.

  • Local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery.

06

What researchers measure

Primary outcomes

  1. Cumulative Opioid Consumption at 48 Hours Postoperatively

    Cumulative opioid consumption measured at 48 hours after surgery

    Time frame: From the end of surgery to 48 hours postoperatively.

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Elsharkawy H, Bajracharya GR, El-Boghdadly K, Drake RL, Mariano ER. Comparing two posterior quadratus lumborum block approaches with low thoracic erector spinae plane block: an anatomic study. Reg Anesth Pain Med. 2019 Mar 28:rapm-2018-100147. doi: 10.1136/rapm-2018-100147. Online ahead of print. PubMed 30923253 ↗
  • Kadam VR, Van Wijk RM, Ludbrook GL, Thiruvenkatarajan V. Anatomical and ultrasound description of two transmuscular quadratus lumborum block approaches at L2 level and their application in abdominal surgery. Anaesth Intensive Care. 2019 Mar;47(2):141-145. doi: 10.1177/0310057X19839931. Epub 2019 May 15. PubMed 31088120 ↗
  • Little C, Rahman S. Quadratus Lumborum Blocks in Nephrectomy: A Narrative Review. Local Reg Anesth. 2021 Apr 19;14:57-65. doi: 10.2147/LRA.S290224. eCollection 2021. PubMed 33907461 ↗
  • He Y, Huang M, Zhong Q, Ni H, Yu Z, Zhang X. Analgesic Effect of Ultrasound-Guided Anterior Quadratus Lumborum Block at the L2 Level in Patients Undergoing Laparoscopic Partial Nephrectomy: A Single-Center, Randomized Controlled Trial. Pain Res Manag. 2022 Dec 15;2022:8958859. doi: 10.1155/2022/8958859. eCollection 2022. PubMed 36569463 ↗

Individual participant data

Plan to share: No — The study protocol and informed consent form did not include provisions for secondary data analysis by external researchers.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Sep 2026 (actual). Primary completion is estimated for Feb 2027, 5 months after the start.

Of 119 non-industry interventional studies with no phase under Carcinoma, Renal Cell, half reached primary completion within 48 months of starting (the median), counting those still running; a quarter within 24 and three quarters within 114. This study's planned 5 months is below that.

Counting every sponsor, half of 126 studies reached it within 45 months; a quarter within 22 and three quarters within 114.

Start moved once since we started tracking on Sep 25, 2026: Jul 2026 → Sep 2026, on Sep 25, 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Jul 11, 2026
First posted
Jul 15, 2026
StartActual
Sep 22, 2026was Jul 2026
Primary completionEst.
Feb 28, 2027
CompletionEst.
Mar 31, 2027
Last update
Sep 25, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Not yet recruiting→Recruiting
changed Sep 25, 2026
Sites
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology is now Recruiting
Sep 25, 2026
Start date
Jul 20, 2026→Sep 22, 2026 (actual)
Sep 25, 2026
Show all 1 update
  1. Sep 25, 2026
    Not yet recruiting→Recruiting
    Union Hospital, Tongji Medical College, Huazhong University of Science and Technology is now Recruiting
    Start date Jul 20, 2026→Sep 22, 2026 (now actual)
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07704970
Responsible party
Xi Wu (Principal Investigator, Huazhong University of Science and Technology) — Principal investigator
First posted
Jul 15, 2026
Start date
Sep 22, 2026
Primary completion
Feb 28, 2027 (estimated)
Completion
Mar 31, 2027 (estimated)
Last update
Sep 25, 2026

Study contacts

Xi Wu
Contact
wu2018whuh@163.com
+8615871715431

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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Studies of the drug tested here: Ropivacaine

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