An observational study in Bruxism, sponsored by Giresun University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 25 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by Giresun University · Observational
Among 66 studies in Bruxism with a site in Turkey — 11 open to participants now, 13 under way, none of them phase 3. Bruxism · Turkey.
Among the 66 studies in Bruxism with a site in Turkey, this one is the 19th largest by enrollment of the 25 observational ones, is one of 18 that started in 2025, is one of 25 observational ones, and was the 61st registered.
151 studies on the registry are indexed under Bruxism; 39 are open to participants now.
This study's enrollment of 56 is below the median of 89 across 55 observational studies indexed under Bruxism.
Browse Bruxism studies →11 of the 66 studies in Bruxism with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 15 Bruxism studies recruiting now, 8 (53%) set no upper age limit and 7 (47%) stop at 75 or younger; 2 take children under 18; 8 take healthy volunteers.
This study: 25 Years to 50 Years · all sexes · healthy volunteers too.
The full table on the hub →66 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 18 started in 2025.
Median enrollment 36 across the 41 interventional studies, 76 across the 25 observational. Of the 52 that completed or were terminated, 2 (4%) have results posted.
None of the 66 has an industry lead sponsor. The 10 most frequent:
Giresun University is the lead sponsor of 57 studies on the registry; 6 are open to participants now.
Giresun University has 1 study filed under Bruxism — fewer than ten, so there is no comparison to draw.
3 of the studies in Bruxism with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07640035Bilecik Seyh Edebali UniversitesiBotulinum Toxin-A for Bruxism Using Digital Occlusal Analysis | 2026-12-20 |
| NCT07241728Inonu UniversityBruxism and Diadinamic Current | 2026-12-20 |
| NCT07665398Necmettin Erbakan UniversityEffect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism | 2026-12-31 |
Among the 66 studies in Bruxism with a site in Turkey, from their registry updates:
The goal of this observational study is to evaluate salivary biomarkers and perceived stress in adults with bruxism compared with healthy individuals. The study aims to determine whether salivary cortisol, immunoglobulin A (IgA), free kappa light chain (FLC-κ), free lambda light chain (FLC-λ), total free light chains, and perceived stress levels differ between individuals with bruxism and healthy controls. The main questions it aims to answer are:
Participants will:
Bruxism is a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible during sleep or wakefulness. Increasing evidence suggests that psychological stress and neuroendocrine mechanisms may contribute to the development and progression of bruxism. Salivary biomarkers provide a non-invasive approach for evaluating physiological responses related to stress, immune function, and inflammation.
The purpose of this observational case-control study is to investigate whether salivary cortisol, immunoglobulin A (IgA), free kappa light chain (FLC-κ), free lambda light chain (FLC-λ), total free light chains, and perceived stress differ between individuals with bruxism and healthy controls. The study also aims to evaluate the relationship between perceived stress and salivary biomarker levels in individuals with bruxism.
Participants diagnosed with bruxism healthy control participants will undergo a standardized clinical examination. Perceived stress will be assessed using the Perceived Stress Scale (PSS-14). Unstimulated whole saliva samples will be collected under standardized conditions and analyzed for cortisol, IgA, free kappa light chain, free lambda light chain, and total free light chain concentrations using validated laboratory methods.
The results of this study are anticipated to enhance the understanding of the biological mechanisms involved in bruxism and to determine if salivary biomarkers can be used as objective markers of stress-related changes in bruxism patients.
The study population consisted of adults with clinically diagnosed bruxism and age- and sex-matched healthy control participants recruited from the Faculty of Dentistry. All participants underwent clinical examination, completed the Perceived Stress Scale (PSS-14), and provided unstimulated saliva samples for biomarker analysis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults diagnosed with bruxism based on clinical diagnostic criteria.
Age- and sex-matched healthy adults without signs or symptoms of bruxism.
Perceived stress score (PSS-14 score)
Comparison of PSS-14 scores between individuals with bruxism and non-bruxism controls.
Time frame: Baseline
Salivary biomarker levels (cortisol, IgA, FLC-κ, FLC-λ, and total FLC)
Comparison of salivary cortisol, IgA, FLC-κ, FLC-λ, and total FLC concentrations between individuals with bruxism and non-bruxism controls
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
Ran from May 2025 to primary completion in Apr 2026, 11 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Giresun University