An observational study in Periodontal Diseases, Hyperuricemia and Oxidative Stress, sponsored by Recep Tayyip Erdogan University Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-26.
Sponsored by Recep Tayyip Erdogan University Training and Research Hospital · Observational
Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism.
A total of 80 individuals aged 18-65 years will be included in this clinical observational study. The periodontal status of the participants will be assessed using clinical periodontal parameters such as probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing. Participants will be divided into four groups according to their periodontal status and the presence of hyperuricemia: individuals with periodontitis and hyperuricemia, individuals with periodontally healthy and hyperuricemia, individuals with periodontitis but without hyperuricemia, and individuals with periodontally healthy and without hyperuricemia. Gingival crevicular fluid and serum samples will be taken from the participants. In these samples, receptor-mediated nuclear factor kappa B ligand, osteoprotegerin, total antioxidant status, total oxidant status, oxidative stress index, interleukin-1 beta, interleukin-10, interleukin-18, and nucleotide-binding oligomerization domain-like receptor protein 3 levels will be analyzed. This study is considered unique because it examines the relationship between hyperuricemia and periodontitis by evaluating inflammation, oxidative stress, and bone metabolism parameters together.
318 studies on the registry are indexed under Alveolar Bone Loss; 79 are open to participants now.
This study's planned enrollment of 80 is above the median of 51 across 46 observational studies indexed under Alveolar Bone Loss.
Browse Alveolar Bone Loss studies →Recep Tayyip Erdogan University Training and Research Hospital is the lead sponsor of 88 studies on the registry; 19 are open to participants now.
Compared within Alveolar Bone Loss, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Periodontal Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Recep Tayyip Erdoğan University Faculty of Dentistry
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Exclusion Criteria:
Other: Collection of gingival crevicular fluid (GCF) and serum samples · Other: Measurement of periodontal clinical parameters
Other: Collection of gingival crevicular fluid (GCF) and serum samples · Other: Measurement of periodontal clinical parameters
Other: Collection of gingival crevicular fluid (GCF) and serum samples · Other: Measurement of periodontal clinical parameters
Other: Collection of gingival crevicular fluid (GCF) and serum samples · Other: Measurement of periodontal clinical parameters
Serum and GCF samples will be collected from participants in the first session
Periodontal clinical parameters will be measured from participants initially
Periodontal pocket depth
The distance between the gingival margin and the base of the pocket will be measured in millimeters.
Time frame: at baseline
clinical attachment loss
The distance between the enamel-cementum junction and the base of the pocket will be measured in millimeters.
Time frame: at baseline
Level of interleukin-1 beta
Interleukin-1 beta levels will be determined from gingival crevicular fluid and serum samples using the ELISA method.
Time frame: at baseline
Level of interleukin-10
Interleukin-10 levels will be determined from gingival crevicular fluid and serum samples using the ELISA method.
Time frame: at baseline
Level of interleukin-18
Interleukin-18 levels will be determined from gingival crevicular fluid and serum samples using the ELISA method.
Time frame: at baseline
Start is estimated for Jun 2026; primary completion for Oct 2026, 3 months later.
Of 22 observational studies under Alveolar Bone Loss, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 27. This study's planned 3 months is below that.
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Recep Tayyip Erdogan University Training and Research Hospital