An interventional study of Postprandial walking and Brief resistance exercise snacks in Metabolic Syndrome and Prediabetes, sponsored by Seoul National University. Not yet recruiting. Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-02.
Sponsored by Seoul National University · Not applicable, Interventional, and Prevention
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks consisting of squats and calf raises performed every 20 minutes during the postprandial period. Continuous glucose monitoring will be used to assess 24-hour glucose responses, and heart rate variability will be measured during the 2-hour postprandial period to evaluate acute autonomic responses.
The main outcome is 24-hour mean glucose derived from continuous glucose monitoring.
Metabolic syndrome and prediabetes are associated with impaired glucose regulation and increased cardiometabolic risk. Light physical activity after meals may help reduce postprandial glucose excursions and improve overall daily glucose control. However, it remains unclear whether brief resistance exercise snacks can provide glucose benefits comparable to postprandial walking under standardized meal conditions.
This study is a randomized crossover trial in adults aged 40 to 65 years with metabolic syndrome and prediabetes. Each participant will complete three experimental conditions in a randomized order: prolonged sitting, 15 minutes of walking after a standardized meal, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. The resistance exercise snacks will consist of simple body-weight exercises, including squats and calf raises.
Glucose responses will be assessed using continuous glucose monitoring. The primary outcome will be 24-hour mean glucose after each experimental condition. Key secondary glycemic outcomes will include 2-hour postprandial glucose incremental area under the curve, 2-hour mean glucose, peak glucose, time to peak glucose, nocturnal mean glucose, and glycemic variability indices. Heart rate variability will be assessed during the 2-hour postprandial period using RR interval data collected with a chest strap heart rate monitor to evaluate acute autonomic responses to each condition.
The purpose of this study is to determine whether brief resistance exercise snacks can improve 24-hour glucose regulation and postprandial glucose responses compared with uninterrupted sitting, and whether these responses are comparable to postprandial walking.
2,116 studies on the registry are indexed under Metabolic Syndrome; 347 are open to participants now.
This study's planned enrollment of 25 is below the median of 60 across 1,572 interventional studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →Seoul National University is the lead sponsor of 32 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
Exclusion Criteria:
Exclusion Criteria:
-
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will remain seated during the 2-hour postprandial period after consuming a standardized meal.
Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal.
Behavioral: Postprandial walking
Participants will perform 3-minute bouts of body-weight resistance exercises, including squats and calf raises, every 20 minutes during the postprandial period after consuming a standardized meal.
Behavioral: Brief resistance exercise snacks
Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Walking intensity will be monitored using heart rate and rating of perceived exertion.
Participants will perform 3-minute bouts of body-weight resistance exercises every 20 minutes during the postprandial period after consuming a standardized meal. The exercise bouts will include squats and calf raises.
24-hour mean glucose
Mean glucose over 24 hours after each experimental condition, derived from continuous glucose monitoring.
Time frame: 24 hours after each experimental condition
2-hour postprandial glucose incremental area under the curve
The 2-hour postprandial glucose incremental area under the curve will be calculated from continuous glucose monitoring data after the standardized meal.
Time frame: 0 to 120 minutes after the standardized meal
Change in RMSSD
Change in the root mean square of successive differences from the pre-meal resting baseline during the 2-hour postprandial period. RMSSD will be calculated from RR interval data collected with a chest strap heart rate monitor.
Time frame: 0 to 120 minutes after the standardized meal
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Seoul National University