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RecruitingNCT07599254Updated May 20, 2026

Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial

A Phase 4 interventional study of root canal irrigation in Apical Periodontitis, sponsored by TC Erciyes University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-20.

Sponsored by TC Erciyes University · Phase 4, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Jun 2026, 4 months ago, but the record still lists the study as recruiting.
  • Registered 4 months after the study started (first participant enrolled Jan 2025, registered May 2025).
  • Started Jan 2025; still recruiting 1 year 9 months later.
Phase
Phase 4
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The relationship between different root canal irrigation techniques and pain after root canal treatment

02

Conditions studied

  • Apical Periodontitis
03

In context

Periapical Periodontitis

246 studies on the registry are indexed under Periapical Periodontitis; 64 are open to participants now.

This study's planned enrollment of 100 is above the median of 60 across 211 interventional studies indexed under Periapical Periodontitis.

Browse Periapical Periodontitis studies →

Lead sponsor

TC Erciyes University is the lead sponsor of 341 studies on the registry; 76 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),

    • Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,
    • Teeth with previous root canal obturation 2-4 mm short of the apex,
    • Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,
    • Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
    • Teeth suitable for rubber dam isolation.

Exclusion criteria

Exclusion Criteria:

  • o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,

    • Teeth exhibiting periodontal attachment loss,
    • Presence of vertical root fractures, external root resorption, or perforations,
    • Teeth with retained broken instruments,
    • Non-restorable teeth,
    • Patients in the pregnancy and breastfeeding period.
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
100 participants (estimated)

Study arms

  • Experimental
    NaOCl/EDTA+CNI Group

    İrrigation

    Drug: root canal irrigation

  • Experimental
    NaOCl/EDTA+PUA Group

    Drug: root canal irrigation

  • Experimental
    NaOCl/Dual Rinse HEDP+CNI Group

    Drug: root canal irrigation

  • Experimental
    NaOCl/Dual Rinse HEDP+PUA Group

    Drug: root canal irrigation

Interventions

  • Drugroot canal irrigation

    Root canal irrigation and postoperative pain

06

What researchers measure

Primary outcomes

  1. Evaluation of the relationship between different root canal irrigation techniques and post-canal treatment pain using surveys.

    Time frame: 3-5 month

07

Study locations

1 of 1 sites recruiting
  • Erciyes University
    Kayseri, Turkey (Türkiye)
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07599254
Lead sponsor
TC Erciyes University
Responsible party
Ipek Eraslan Akyuz (Dr., TC Erciyes University) — Principal investigator
First posted
May 20, 2026
Start date
Jan 1, 2025
Primary completion
Jun 5, 2026 (estimated)
Completion
Jul 15, 2026 (estimated)
Last update
May 20, 2026

Study contacts

İPEK E ERASLAN AKYÜZ
Contact
ipekemamak@hotmail.com
+905385591409

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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