An interventional study of Core Stabilization Exercise in Adolescence Idiopathic Scoliosis, sponsored by Istanbul University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 10 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Istanbul University · Not applicable, Interventional, and Treatment
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Among 132 studies in Scoliosis with a site in Turkey — 32 open to participants now, 35 under way, none of them phase 3. Scoliosis · Turkey.
Among the 132 studies in Scoliosis with a site in Turkey, this one is the 44th largest by planned enrollment of the 78 interventional ones that give a count, is one of 16 that started in 2026, is one of 77 with no phase, reaches primary completion later than 21 of the 34 other live ones, and was the 116th registered.
660 studies on the registry are indexed under Scoliosis; 186 are open to participants now.
Browse Scoliosis studies →32 of the 132 studies in Scoliosis with a site in Turkey are open now. Recruiting first, the newest first:
Kahramanmaras Sutcu Imam University · Sites in Turkey
Ages 10–17
Bitlis Eren University · Sites in Turkey
Ages 10–18
Bezmialem Vakif University · Sites in Turkey
Ages 10–19 · Healthy volunteers
Bezmialem Vakif University · Sites in Turkey
Ages 10–19
Ankara Yildirim Beyazıt University · Sites in Turkey
Ages 10–18
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 117 Scoliosis studies recruiting now, 23 (20%) set no upper age limit and 88 (75%) stop at 75 or younger; 98 take children under 18; 14 take healthy volunteers.
This study: 10 Years to 18 Years · all sexes · no healthy volunteers.
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132 studies; the count open now beside each. This study's row is marked.
First in 2008; this study’s year is marked. 16 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 30 is below the median of 45 across 386 interventional studies indexed under Scoliosis.
Median enrollment 32 across the 78 interventional studies, 60 across the 54 observational. Of the 90 that completed or were terminated, 0 (0%) have results posted.
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1 of 132 have an industry lead sponsor. The 10 most frequent:
Istanbul University is the lead sponsor of 512 studies on the registry; 76 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 1 (20%) have results posted.
Istanbul University has 8 studies filed under Scoliosis — fewer than ten, so there is no comparison to draw.
8 of the studies in Scoliosis with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07909174Kahramanmaras Sutcu Imam UniversityTurkish Adaptation and Validation of the Scoliosis Misconception Scale in Adolescents With Idiopathic Scoliosis | 2026-11 |
| NCT07767591Bezmialem Vakif UniversitySleep Quality in Adolescents With Idiopathic Scoliosis | 2026-12-01 |
| NCT07321600Hacettepe UniversityResisted Inspiratory Muscle Training Applied in Addition to PSSE-Schroth Exercises | 2026-12-02 |
| NCT07676019Acibadem UniversityPsychometric Properties of the Turkish Version of the Staffordshire Adolescent Idiopathic Scoliosis Questionnaire | 2027-01-02 |
| NCT07758712Bezmialem Vakif UniversityEffectiveness of a Horse Riding Simulator in Adolescents With Idiopathic Scoliosis | 2027-01-10 |
Add all 8 to your calendar (.ics) → With an account.
Among the 132 studies in Scoliosis with a site in Turkey, from their registry updates:
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Background and Problem Overview Adolescent Idiopathic Scoliosis (AIS) is a progressive musculoskeletal disorder characterized by a three-dimensional deformation of the spine occurring during adolescence. Diagnosis is typically established with a Cobb angle exceeding 10° and the presence of axial rotation. While the exact etiology remains unknown, leading theories include tissue abnormalities (muscle fibers, bone volume), impaired spinal biomechanics (asymmetric bone growth), and neurological factors (asymmetric cortical thickness, cerebral lateralization, and body schema distortions).
The progressive nature of AIS, particularly the high risk of advancement at the onset of puberty, complicates clinical decision-making. Treatment is traditionally divided into three stages:
Observation and Exercise: For Cobb angles between 10°-25°.
Exercise and Bracing: For Cobb angles between 25°-45°.
Surgery: For Cobb angles exceeding 45°.
Despite these guidelines, the unpredictable progression of the disease and difficulties in treatment adherence create significant dilemmas. Specifically, for cases on the borderline of surgical indication, clinicians face the challenge of choosing between immediate surgery or conservative monitoring. Currently, there is no definitive method to predict progression, and patients are typically monitored in 6-month intervals. During these intervals, a patient's condition may remain stable or deteriorate significantly.
Furthermore, guidelines recommend wearing a brace for an average of 18 hours per day, often for several years. This requirement is physically and psychologically demanding for adolescents, leading to poor compliance due to aesthetic concerns, functional limitations, and skin irritation. The inability to predict progression often leads to overtreatment (unnecessary bracing) or undertreatment (delayed intervention), both of which pose risks to the patient's long-term health.
Radiological Concerns Disease progression is monitored via direct radiography (X-rays). However, frequent imaging increases the lifetime risk of cancer due to cumulative ionizing radiation. Notably, the risk of breast cancer in girls with AIS is reported to be approximately seven times higher than in the healthy population. Conversely, extending follow-up intervals risks missing windows for early intervention. An artificial intelligence (AI) model capable of predicting curve progression could optimize imaging frequency, ensuring safety while maintaining clinical efficacy.
Objective and Methodology of the Study
The primary aim of this research is to develop a machine learning-based model to predict the Cobb angle following a 12-week exercise intervention. The model will utilize comprehensive baseline and post-treatment data, including:
Demographic and Anthropometric Data (Age, height, weight, gender).
Clinical Assessments (Cobb angle, Risser score, angle of trunk rotation).
Functional and Physical Metrics (Trunk muscle strength, Maximal Inspiratory and Expiratory Pressure [MIP/MEP], Biodex balance measurements).
Visual Assessments (Walter Reed Visual Deformity Scale [WRVAS]).
Research Hypotheses
Primary Hypothesis: A machine learning model trained on pre- and post-exercise assessment data can significantly predict the Cobb angle at the end of a 12-week period with both statistical and clinical accuracy.
Secondary Hypothesis: By predicting the risk of progression (the probability of an increase in Cobb angle), this model will contribute to reducing unnecessary surgical interventions, overtreatment (bracing/surgery), and cumulative X-ray exposure.
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Exclusion Criteria:
Participants in this arm are adolescents with idiopathic scoliosis who receive a standardized core stabilization exercise program as part of routine physiotherapy care. The intervention is applied for 12 weeks. All participants undergo clinical and functional assessments before and after the intervention, including radiographic evaluation of Cobb angle and other scoliosis-related parameters such as trunk rotation, muscle strength, balance, and respiratory muscle function. The purpose of this arm is not to compare different treatments, but to generate and validate a machine learning model for predicting post-intervention disease progression based on pre- and post-treatment clinical data.
Behavioral: Core Stabilization Exercise
weeks. The exercise program focuses on improving trunk muscle control, postural stability, and spinal alignment. The intervention is delivered as part of routine physiotherapy care. Participants perform exercises targeting deep trunk stabilizers, including abdominal, paraspinal, and pelvic musculature. Exercise progression is based on patient tolerance and clinical evaluation. Clinical and radiological assessments are performed before and after the intervention, including Cobb angle measurement and functional evaluations such as muscle strength, balance, respiratory muscle strength, and trunk rotation.
Cobb Angle
The primary outcome is the Cobb angle measured 12 weeks after core stabilization exercise intervention in adolescents with idiopathic scoliosis. The Cobb angle is obtained from standard standing anteroposterior or posteroanterior spinal radiographs and represents the degree of spinal curvature. This outcome is used as the target variable for the machine learning model to predict post-intervention disease progression.
Time frame: 12 weeks
Demographic Parameters
Age, Sex, BMI, Type of Scoliosis
Time frame: 12 weeks
Risser Score
Risser score is a radiographic measure used to assess skeletal maturity by evaluating the degree of ossification of the iliac apophysis on pelvic X-rays.
Time frame: 12 weeks
Angle of Trunk Rotation
Angle of trunk rotation is a clinical measurement used to assess axial spinal deformity in scoliosis by quantifying trunk asymmetry during the forward bending test using a scoliometer.
Time frame: 12 weeks
The Walter Reed Visual Assessment Scale
The Walter Reed Visual Assessment Scale is a patient-reported outcome measure used to evaluate perceived cosmetic deformity in scoliosis through standardized visual representations of body asymmetry.
Time frame: 12 weeks
Biodex postural stability and limits of stability
Biodex postural stability and limits of stability are objective balance assessments that evaluate a person's ability to maintain and control their center of pressure during static and dynamic conditions using a computerized balance platform.
Time frame: 12 weeks
Respiratory Pressure
Maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) are measures obtained using a mouth pressure device that assess respiratory muscle strength by recording the maximal pressures generated during forced inhalation and exhalation.
Time frame: 12 weeks
Plan to share: No
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Started Apr 2026 (actual). Primary completion is estimated for Sep 2026, 4 months after the start.
Of 223 non-industry interventional studies with no phase under Scoliosis, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 58. This study's planned 4 months is below that.
Counting every sponsor, half of 233 studies reached it within 22 months; a quarter within 8 and three quarters within 60.
How these figures are worked out, and which studies are left out of them.
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