An interventional study of Scaling and Root Planing and Diode Laser in Periodontitis and Kidney Transplant Recipients, sponsored by Military Hospital 103. Recruiting at 2 sites in Vietnam. Per ClinicalTrials.gov, last updated 2026-04-16.
Sponsored by Military Hospital 103 · Not applicable, Interventional, and Treatment
This randomized controlled trial evaluates the efficacy of diode laser-assisted non-surgical periodontal therapy in kidney transplant recipients with periodontitis. Eighty participants will be allocated to two parallel groups: scaling and root planing (SRP) with adjunctive diode laser therapy or SRP alone. Clinical periodontal parameters, blood biomarkers, radiographic findings, and subgingival microbiome profiles will be assessed at baseline and during follow-up. The study aims to determine whether adjunctive diode laser therapy provides superior clinical and biological improvement compared with SRP alone.
Exclusion Criteria:
Participants receive full-mouth scaling and root planing combined with adjunctive diode laser treatment according to the study protocol.
Procedure: Scaling and Root Planing · Device: Diode Laser
Participants receive full-mouth scaling and root planing alone according to the study protocol
Procedure: Scaling and Root Planing
Conventional non-surgical periodontal therapy performed according to the study protocol in both groups.
Adjunctive diode laser application to periodontal pockets after SRP in the experimental arm. Device specifications, wavelength, power settings, mode, fiber size, number of applications, and treatment sessions should match the approved protocol exactly.
Change in clinical attachment level (CAL)
Mean change in CAL, measured in millimeters.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in probing pocket depth (PPD)
Mean change in CAL, measured in millimeters.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in bleeding on probing (BOP)
Percentage of sites with BOP.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in gingival index (GI)
Mean GI score
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in plaque index (PlI)
Mean plaque index score.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in OHI-S
Mean simplified oral hygiene index score.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in platelet count
Platelet count from peripheral blood test.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in C-reactive protein (CRP)
CRP concentration.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in subgingival microbiome composition by 16S rRNA sequencing
Relative abundance and diversity metrics of subgingival microbiota.
Time frame: Baseline and 1 month
Radiographic change in alveolar bone status
Radiographic change in alveolar bone status assessed according to the study imaging protocol
Time frame: Baseline and 6 months
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Military Hospital 103