An interventional study of Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols in Clear Aligner Therapy, sponsored by Jordan University of Science and Technology. Active, not recruiting at 1 site in Jordan. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-13.
Sponsored by Jordan University of Science and Technology · Not applicable, Interventional, and Diagnostic
The aim of this two-arm randomized clinical trial was to compare the effect of 7-day and 14-day orthodontic clear aligner wear protocols on external apical root resorption (EARR) and pain perception
Fifty adult patients (21 Male and 29 female with a mean age of 23.7 ± 1.8) presented at the postgraduate orthodontic clinics at Jordan University of Science and Technology (JUST) were randomly allocated into a 7-day or 14-day aligner change protocol. Each patient underwent a standardized series of digital periapical radiographs (three upper and three lower). Baseline radiographs (T0) were taken before the initiation of treatment, and follow-up radiographs (T1) were collected after six months of aligner therapy.
EARR was measured from a line drawn at the cemento-enamel junction (CEJ) to the tooth's apex before treatment (T₀), and after treatment (T1), the difference in length was calculated and graded using the Malmgren Index. Pain perception was assessed using a verbal rating scale (VRS) at six-time intervals (24 hours, first week, second week, first month, third month and sixth month). Statistical analyses were used to compare pre- and post-treatment changes within and between the groups. Multiple linear regression was used to identify predictors of EARR.
43 studies on the registry are indexed under Root Resorption; 9 are open to participants now.
This study's enrollment of 52 is above the median of 29 across 36 interventional studies indexed under Root Resorption.
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Other: Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols
Other: Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols
One group should change the orthodontic clear aligner every week (7 days) and the second group every two weeks (14 days)
Root resorption
Peri-apical radiographs will be taken before and after the treatment, tooth root length will be measured before and after treatment from the radiographs
Time frame: 6 months
Pain perception
Pain perception will be measured in the two groups
Time frame: After 24 hours, 1 week, 2 weeks, 1 month, 3 months and 6 months
This study is active, not recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Jordan University of Science and Technology