An observational study in Thoracic Neoplasm, Pulmonary Nodules and Non-oncological Pulmonary Pathologies, sponsored by Casa di Cura Dott. Pederzoli. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Casa di Cura Dott. Pederzoli · Observational
This research study aims to retrospectively and prospectively analyze the clinical, anamnestic, functional, biological data of patients who have performed or will perform non-contrast chest photon count CT.
The use of contrast medium is evaluated by the physician. Main objective The study aims to understand how many people who undergo non-contrast photon-counting chest CT have: lung nodules, chest tumors, and other non-cancerous lung diseases.
Secondary objectives
The enrollment phase will last 12 months and will begin with the approval of the study. At this stage, clinical data already present in the patient's medical record and data relating to the photon count CT examination will be collected. After the enrollment phase, the patient will be observed for a further total duration of 10 years: in particular, a follow-up visit will be arranged at two, five and ten years. More specifically, if there are no radiological elements that require scheduling a visit to the center, the patient will be contacted by telephone for a telematic update of the data. If, however, pulmonary alterations are identified during the study, the patient will be referred to the Reference Operating Unit, as per clinical practice, to continue with the most appropriate personalized diagnostic-therapeutic process. In these cases, the patient will be contacted by telephone and an appointment with the institution will be suggested.
115 studies on the registry are indexed under Thoracic Neoplasms; 30 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 140 across 25 observational studies indexed under Thoracic Neoplasms.
Browse Thoracic Neoplasms studies →Casa di Cura Dott. Pederzoli is the lead sponsor of 15 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The population of this study consists of all patients who perform the Photon Counting Computed Tomography
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The enrollment phase of the subjects will last 12 months and will begin with the approval of the study. During the following year, all the data collected from a statistical, mathematical, and artificial intelligence perspective will be analyzed. The data collected are anamnestic, functional where available, biological and radiological data. Following the enlistment phase, subjects will be observed for a total duration of 10 years: in particular, a follow-up visit will be arranged at two, five and ten years. More specifically, if there are no radiological elements that require specific follow-ups, the subject will be contacted by telephone for a telematic update of the data. If, however, pulmonary alterations are identified during the study, the patient will be referred to the Reference Operating Unit, as per clinical practice, to continue with the most appropriate personalized diagnostic-therapeutic process.
Describe the frequency of patients performing chest photon counting CT without mdc with pulmonary nodules
Number of pulmonary nodules
Time frame: through study completion, an average of 1 year
Describe the frequency of thoracic malignancies in subjects performing chest photon counting CT without mdc.
Number of thoracic malignancies
Time frame: through study completion, an average of 1 year
Describe the frequency of non-oncological pulmonary diseases of subjects performing chest photon counting CT without mdc.
Number of non-oncological pulmonary diseases
Time frame: through study completion, an average of 1 year
Accuracy of the AI-based lung digital twin model measured by mean absolute error (MAE) between model-predicted and observed pulmonary function parameters (FEV1, FVC, DLCO)
Time frame: through study completion, an average of 1 year
Change in lung structural abnormalities measured by quantitative CT parameters (lung density, lung volume, lesion size)
Time frame: through study completion, an average of 1 year
Association between lung imaging abnormalities and clinical, biological, and laboratory variables assessed by multivariable regression analysis
Time frame: Baseline to 12 months
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Casa di Cura Dott. Pederzoli