An interventional study of Exercise and control in Chronic Kidney Disease, sponsored by Casa di Cura Dott. Pederzoli. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-27.
Sponsored by Casa di Cura Dott. Pederzoli · Not applicable, Interventional, and Other
This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
Exclusion Criteria:
participants will undergo a combined endurance and resistance exercise training
Other: Exercise
participants performs outcome measures sessions only, including blood sample collection.
Other: control
All participants will be involved in the exercise training three times per week for 24 weeks: endurance exercise training, resistant exercise training
outcome measures
Gait speed (6MWT)
• Assess the effect of exercise on physical performance and quality of life on pa-tients with chronic kidney disease from stage 1 to end stage renal disease on maintenance haemodialysis or on conservative treatment
Time frame: through study completion, an average of 1 year
Physical performance (SPPB)
Time frame: through study completion, an average of 1 year
Cardiopulmonary capacity (CPET)
Time frame: through study completion, an average of 1 year
Lower limbs strength (1-RM)
Time frame: through study completion, an average of 1 year
Maximum isometric strength of the upper limb (hand grip)
Time frame: through study completion, an average of 1 year
Daily physical activity amount (IPAQ)
Time frame: through study completion, an average of 1 year
Quality of life (SF36)
Time frame: through study completion, an average of 1 year
Nutritional status (24HR, FFQ)
Time frame: through study completion, an average of 1 year
Body composition (DEXA, BIVA)
Time frame: through study completion, an average of 1 year
Psychological and psychosocial conditions (BDI, MMSE)
Time frame: through study completion, an average of 1 year
Hemodynamic and vascular functions (SV, CO, HR, FBF, FMD, sPLM)
Time frame: through study completion, an average of 1 year
Muscular oxygen extraction (NIRS)
Time frame: through study completion, an average of 1 year
Neuromuscular functions (MCV, RFD)
Time frame: through study completion, an average of 1 year
effect of physical activity on mitochondrial activity
Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, MOTS-c (mg)
Time frame: through study completion, an average of 1 year
Effect of physical activity on mitochondrial activity
Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, humanin (mg)
Time frame: through study completion, an average of 1 year
Plan to share: No
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Casa di Cura Dott. Pederzoli