An observational study in Keratoconus, sponsored by Centre Hospitalier Régional Metz-Thionville. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Centre Hospitalier Régional Metz-Thionville · Observational
Observational study comparing patients with inter-eye asymmetric keratoconus with patients with inter-eye symmetric keratoconus.
Detailed description: Keratoconus is a condition resulting in corneal thinning and visual impairment due to irregular astigmatism. Most cases are bilateral, although the severity is often asymmetric between both eyes. The aim of our study is to examine risk factors for inter-eye asymmetry in terms of severity in patients with a confirmed diagnosis of keratoconus. Patients were reviewed for keratoconus staging for each eye according to the Amsler-Krumeich classification to define asymmetry and separated in groups according to the laterality of the worst eye and in a group where both eyes were symmetric in terms of asymmetry. A multivariate logistic regression was performed on various risk factors to explore keratoconus inter-eye asymmetry.
307 studies on the registry are indexed under Keratoconus; 56 are open to participants now.
This study's enrollment of 154 is above the median of 130 across 94 observational studies indexed under Keratoconus.
Browse Keratoconus studies →Centre Hospitalier Régional Metz-Thionville is the lead sponsor of 118 studies on the registry; 20 are open to participants now.
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Patients presenting to the attending ophthalmologist during the study period with previously diagnosed unilateral or bilateral keratoconus or patients newly diagnosed with unilateral or bilateral keratoconus during the study period.
Exclusion Criteria:
Patients presenting to the attending ophthalmologist during the study period with previously diagnosed unilateral or bilateral keratoconus or (ii) patients newly diagnosed with unilateral or bilateral keratoconus during the study period.
Behavioral: Questionnaire
Questionnaire about eye rubbing habits
Risk factors for inter-eye keratoconus asymmetry in terms of severity
Logistic regression
Time frame: Day 1
Plan to share: No — According to French law and the guidelines of the French Data Protection Authority (CNIL), individual participant data cannot be publicly shared. However, study findings will be disseminated through peer-reviewed publications and presentations at scientific conferences.
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Régional Metz-Thionville