An observational study in Vastus Medialis, Ultrasonographic and Patello Femoral Pain Syndrome, sponsored by Hasan Kalyoncu University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-20.
Sponsored by Hasan Kalyoncu University · Observational
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Among 30 studies in Patellofemoral Pain Syndrome with a site in Turkey — 6 open to participants now, 6 under way, none of them phase 3. Patellofemoral Pain Syndrome · Turkey.
Among the 30 studies in Patellofemoral Pain Syndrome with a site in Turkey, this one is one of 5 that started in 2026, is one of 9 observational ones, and was the 29th registered.
297 studies on the registry are indexed under Patellofemoral Pain Syndrome; 74 are open to participants now.
Browse Patellofemoral Pain Syndrome studies →6 of the 30 studies in Patellofemoral Pain Syndrome with a site in Turkey are open now. Recruiting first, the newest first:
Firat University · Sites in Turkey
Ages 18–50
Yeditepe University · Sites in Turkey
Ages 20–59
Hacettepe University · Sites in Turkey
Ages 18–45 · Healthy volunteers
Hacettepe University · Sites in Turkey
Ages 18–40 · Healthy volunteers
Recep Tayyip Erdogan University · Sites in Turkey
Ages 18–45
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 45 Patellofemoral Pain Syndrome studies recruiting now, 3 (7%) set no upper age limit and 41 (91%) stop at 75 or younger; 7 take children under 18; 13 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · healthy volunteers too.
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30 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 5 started in 2026.
This study's planned enrollment of 40 is close to the median of 43 across 48 observational studies indexed under Patellofemoral Pain Syndrome.
Median enrollment 39 across the 21 interventional studies, 50 across the 9 observational. Of the 18 that completed or were terminated, 0 (0%) have results posted.
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None of the 30 has an industry lead sponsor. The 10 most frequent:
Hasan Kalyoncu University is the lead sponsor of 166 studies on the registry; 33 are open to participants now.
Hasan Kalyoncu University has 1 study filed under Patellofemoral Pain Syndrome — fewer than ten, so there is no comparison to draw.
1 of the studies in Patellofemoral Pain Syndrome with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07562425Firat UniversityEffects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome | 2026-11-20 |
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Among the 30 studies in Patellofemoral Pain Syndrome with a site in Turkey, from their registry updates:
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The aim of this study is to examine in detail the ultrasonographic characteristics of the vastus medialis obliquus and vastus medialis longus muscles in individuals with patellofemoral pain syndrome and to compare these findings with those of healthy individuals. It is anticipated that the results obtained will contribute to a better understanding of the muscle-based mechanisms of PFAS and provide a scientific basis for the development of muscle-specific assessment and intervention strategies in physical therapy and rehabilitation practices.
Patellofemoral pain syndrome (PFAS) is a musculoskeletal problem characterized by pain in the front of the knee joint, commonly seen in young and physically active individuals. The etiology of PFAS is multifactorial and is associated with abnormal loading of the patella within the femoral trochlear groove, alterations in joint biomechanics, and functional deficiencies of the surrounding soft tissues. These mechanical irregularities in the patellofemoral joint can lead to pain, loss of function, and activity limitations over time. The quadriceps femoris muscle group plays a fundamental role in providing dynamic stability to the patella. The vastus medialis obliquus (VMO) and vastus medialis longus (VML) muscles within this muscle group are critical for controlling the patella medially and maintaining its proper alignment within the femoral groove. It is known that the oblique fiber structure of the VMO muscle provides medial stabilizing force to the patella, while the VML muscle contributes to force production during knee extension and overall patellar guidance with its longer fibers. In individuals with PFAS, delayed activation patterns, decreased muscle strength, and morphological changes in the vastus medialis muscle have been reported. However, it is observed in the literature that the VMO and VML muscles are treated as a single structure in most studies, and the separate morphological characteristics of these two muscles and their relationship with patellofemoral pain have not been sufficiently investigated. However, the different anatomical, biomechanical, and functional characteristics of these muscles necessitate that their roles in PFAS pathophysiology be evaluated separately. Ultrasonography is a non-invasive, reliable, and reproducible imaging method for evaluating the morphological characteristics of muscle tissue and is increasingly used in clinical research. Ultrasonographic evaluation allows for the objective examination of muscle thickness, cross-sectional area, and architectural features, thereby providing important information about structural changes in muscle function. The aim of this study is to examine in detail the ultrasonographic characteristics of the vastus medialis obliquus and vastus medialis longus muscles in individuals with patellofemoral pain syndrome and to compare these findings with healthy individuals. It is anticipated that the results will contribute to the understanding of the muscle-based mechanisms of PFAS and provide a scientific basis for the development of muscle-specific assessment and intervention strategies in physical therapy and rehabilitation practices.
The study will include individuals aged 18-65 who have been diagnosed with patellofemoral pain syndrome, as well as healthy volunteers with similar characteristics in terms of age and gender. The study group will consist of individuals who have applied to a physical therapy and rehabilitation clinic or who have been referred to relevant units. The control group will be selected from healthy volunteers who do not have any knee pain or lower extremity musculoskeletal problems.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The study will include individuals aged 18-65 who have been diagnosed with patellofemoral pain syndrome, as well as healthy volunteers with similar characteristics in terms of age and gender.
The study will include individuals aged 18-65 who have been diagnosed with patellofemoral pain syndrome, as well as healthy volunteers with similar characteristics in terms of age and gender.
Ultrasonographic Measurement
A B-mode ultrasound device with a high-frequency (7-12 MHz) linear probe will be used to evaluate muscle architecture. Ultrasound is a reliable, reproducible, and non-invasive imaging method for assessing the morphological characteristics of muscle tissue. Ultrasonographic evaluations will be performed by an experienced researcher in musculoskeletal ultrasonography, in a quiet and standard environment. A high-frequency (7-12 MHz) linear probe will be used during measurements. Participants will be placed on the evaluation table in a supine position, with the knee joint fully extended and relaxed. Before measurements, anatomical reference points will be determined using a tape measure, and temporary markings will be made on the skin. Vastus Medialis Obliquus (VMO): VMO muscle thickness measurement will be performed in the region where the oblique orientation of the muscle fibers is prominent, using the upper-medial edge of the patella as a reference. The measurement point will be determ
Time frame: through of the study, average 4 months
Plan to share: No
Start is estimated for Feb 2026; primary completion for Apr 2026, 2 months later.
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This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Patellofemoral Pain Syndrome →