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Not yet recruitingNCT07812519Updated Sep 28, 2026

Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain

An observational study in Patellofemoral Pain Syndrome, sponsored by Ted Gunhamn. Not yet recruiting. Open to participants aged 15 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-28.

Sponsored by Ted Gunhamn · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
30
Ages
15 Years to 35 Years
Sex
All
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Study summary

This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. The participants will throughout the exercise trial report pain levels and continue until 1) not being able to perform the exercise as instructed or 2) reaching a pain level of 5/10 (which is a common threshold for acceptable pain within rehabilitation). During this trial, the participants will be filmed and a biomechanical analysis will be performed to see if/how compensatory movements occur.

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Conditions studied

  • Patellofemoral Pain Syndrome

Keywords

  • Patellofemoral Pain
  • Biomechanichs
  • Single leg squat
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In context

Patellofemoral Pain Syndrome

297 studies on the registry are indexed under Patellofemoral Pain Syndrome; 74 are open to participants now.

This study's planned enrollment of 30 is below the median of 43 across 48 observational studies indexed under Patellofemoral Pain Syndrome.

Browse Patellofemoral Pain Syndrome studies →

Lead sponsor

Ted Gunhamn is the lead sponsor of 2 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
15 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

This project will include patients diagnosed with PFP (ICD-10: M22.2).

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
  • Aged 15-35 years.
  • A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.

Exclusion criteria

Exclusion Criteria:

  • Any prior injury or condition with residual symptoms that may affect the results.
  • Current injury or condition affecting the performance of the test.
  • Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.
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Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
30 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patellofemoral Pain

    Patients diagnosed with patellofemoral pain syndrome by health care provider.

    Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION

  • Control

    Healthy adults without injuries/diseases preventing the participants from performing the trial to voluntary muscular failure

    Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Interventions

  • OtherEXERCISE TRAINING WITH OR WITHOUT MEDICATION

    Resistance training to muscular failure in patients with patellofemoral pain.

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What researchers measure

Primary outcomes

  1. Pain Response

    Numeric pain rating scale 0-10. Participants will rate their perceived pain at baseline before the trial, during the trial and the day after the trial.

    Time frame: Approximately 24 hours, from baseline before the trial and the day after the trial.

  2. Knee extensor moment (Nm)

    Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)

    Time frame: Changes in knee extensor moment between the first and final repetition during the trial, approximately 2 minutes.

  3. Hip extensor moment (Nm)

    Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)

    Time frame: Changes in hip extensor moment between the first and final repetition during the trial, approximately 2 minutes.

  4. Knee flexion angle (degrees)

    Knee flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)

    Time frame: Changes between in knee flexion angle between the first and final repetition during the trial, approximately 2 minutes.

  5. Hip flexion angle (degress)

    Hip flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)

    Time frame: Changes between in hip flexion angle between the first and final repetition during the trial, approximately 2 minutes.

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Minor edits
Nothing that changes what the study is or who can join. Edited: responsible party
1 update, last Sep 28, 2026
Show all 1 update
  1. Sep 28, 2026
    Minor edits only
    + 1 other change: responsible party

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07812519
Lead sponsor
Ted Gunhamn
Collaborators
Västra Götalandsregionen, Molndal Hospital
Responsible party
Ted Gunhamn (PhD Candidate, Linnaeus University) — Sponsor-investigator
First posted
Sep 10, 2026
Start date
Dec 2026 (estimated)
Primary completion
Dec 2027 (estimated)
Completion
May 2028 (estimated)
Last update
Sep 28, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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