An interventional study of Transcranial Magnetic Stimulation in Stuttering, Adult, sponsored by Kansas State University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-05.
Sponsored by Kansas State University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if repeated transcranial magnetic stimuli (rTMS) can treat stuttering in adults. The main questions it aims to answer are:
Participants will:
Measures must be obtained to in preparation for TMS treatment. Structural MRI and resting-state functional MRI (rsfMRI) recordings will be obtained from the participant, and they will undergo a neuronavigational session to determine best placement for the electrodes.
MRI/rsfMRI recordings: The structural MRIs will be obtained and used for TMS neuronavigation. Resting-state functional MRI will be recorded for 8 min with the eyes open. rTMS will be delivered at 10 Hz for 10 min with a stimulation intensity of 120% of the resting motor threshold (rMT).
Neuronavigation: The TMS coil will be navigated with a neuronavigation system using the individual MRIs. rTMS targets: rTMS will be delivered to the left inferior frontal gyrus (IFG). We will use the neuronavigation system to identify the IFG.
Three pre-treatment and 2 post-treatment sessions will each obtain data from the following measurements:
74 studies on the registry are indexed under Stuttering; 23 are open to participants now.
This study's planned enrollment of 10 is below the median of 44 across 57 interventional studies indexed under Stuttering.
Browse Stuttering studies →Kansas State University is the lead sponsor of 31 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
There is only one arm to this study. All participants will receive 10 days of Transcranial Magnetic Stimulation to specific cortical speech and motor areas.
Device: Transcranial Magnetic Stimulation
This study uses Transcranial Magnetic Stimulation (TMS) applied to specific speech and motor areas of the brain to stimulate cortical areas that experience reduced activations during left-hemisphere dominant tasks in people who stutter.
Changes in functional connectivity with resting-state electroencephalography (rs-EEG)
A seed-based functional connectivity analysis will be carried out between the two stimulated brain areas. To assess the changes in effective connectivity, the investigators will compare the seed-based connectivity values across sessions.
Time frame: Baseline, immediately post-treatment, and one week after post-treatment.
Changes in behavioral measures of stuttering and phonological processing.
To assess functional changes as a result of rTMS treatment, comparison of eye tracking measurements of duration, dwell time, and number of fixations of eye movements while completing speech and language-based tasks are compared across sessions.
Time frame: Baseline, immediately post-treatment, and one week after post-treatment.
Plan to share: Yes — IPD used in the results publication with be shared with other researchers.
Started Feb 2026 (actual). Primary completion is estimated for Dec 2027, 22 months after the start.
Of 37 interventional studies with no phase under Stuttering, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 38. This study's planned 22 months is below that.
How these figures are worked out, and which studies are left out of them.
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Kansas State University