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RecruitingNCT05286151Updated Oct 15, 2026

Network Connectivity and Temporal Processing in Adolescents Who Stutter

An interventional study of Rhythm discrimination in Stuttering, Childhood and Stuttering, sponsored by University of Michigan. Recruiting at 1 site in United States. Open to participants aged 9 Years to 13 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-15.

Sponsored by University of Michigan · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Started Jul 2022; still recruiting 4 years 3 months later.
Updated Oct 15, 2026Primary completion movedStudy completion movedGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
500
Allocation
Non-randomized
Ages
9 Years to 13 Years
Sex
All
01

Study summary

The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

Read the detailed description

Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.

02

Conditions studied

  • Stuttering, Childhood
  • Stuttering

Keywords

  • Rhythm
  • Temporal processing
  • Healthy children
  • Speech disorders
  • Timing
03

In context

Stuttering

74 studies on the registry are indexed under Stuttering; 23 are open to participants now.

This study's planned enrollment of 500 is above the median of 44 across 57 interventional studies indexed under Stuttering.

Browse Stuttering studies →

Lead sponsor

University of Michigan is the lead sponsor of 1,506 studies on the registry; 192 are open to participants now.

Of its 169 completed or terminated interventional studies of FDA-regulated products, 133 (79%) have results posted.

Browse University of Michigan studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
9 Years to 13 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion Criteria Children who stutter:

  • English as primary language
  • Current or past stuttering diagnosis

Inclusion Criteria Children who do not stutter:

  • English as primary language

Exclusion Criteria Children who stutter:

  • Diagnosed/under treatment for any neurological or psychiatric conditions
  • Head trauma with loss of consciousness
  • Major medical illness
  • Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments)
  • Face, motor, or reflex abnormalities

Exclusion Criteria Children who do not stutter:

  • Personal or family history of stuttering
  • Diagnosed/under treatment for any neurological or psychiatric conditions
  • Head trauma with loss of consciousness
  • Major medical illness
  • Hearing loss
  • Language/motor delay (below -2 standard deviations on standardized assessments
  • Face, motor, or reflex abnormalities
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
500 participants (estimated)

Study arms

  • Experimental
    Children who stutter

    Children who stutter

    Behavioral: Rhythm discrimination

  • Experimental
    Children who do not stutter

    Children who do not stutter

    Behavioral: Rhythm discrimination

Interventions

  • BehavioralRhythm discrimination

    Participants will complete a rhythm discrimination task once per year for 3 years.

06

What researchers measure

Primary outcomes

  1. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 1

  2. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 2

  3. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 3

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jul 2022 (actual). Primary completion is estimated for Jan 2028, 66 months after the start.

Of 37 interventional studies with no phase under Stuttering, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 38. This study's planned 66 months is above that.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 15, 2026: primary completion Jan 2027 → Jan 2028 and completion Jan 2027 → Jan 2028.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Mar 9, 2022
First posted
Mar 18, 2022
StartActual
Jul 23, 2022
Primary completionEst.
Jan 31, 2028was Jan 2027
CompletionEst.
Jan 31, 2028was Jan 2027
Last update
Oct 15, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Primary completion
Jan 31, 2027→Jan 31, 2028
Oct 15, 2026
Study completion
Jan 31, 2027→Jan 31, 2028
Oct 15, 2026
Show all 1 update
  1. Oct 15, 2026
    Primary completion Jan 31, 2027→Jan 31, 2028
    Study completion Jan 31, 2027→Jan 31, 2028
    + 2 other changes: verification date and oversight details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT05286151
Lead sponsor
University of Michigan
Collaborators
National Institute on Deafness and Other Communication Disorders (NIDCD)
Responsible party
Soo-Eun Chang (Associate Professor of Psychiatry, University of Michigan) — Principal investigator
First posted
Mar 18, 2022
Start date
Jul 23, 2022
Primary completion
Jan 31, 2028 (estimated)
Completion
Jan 31, 2028 (estimated)
Last update
Oct 15, 2026

Study contacts

Soo-Eun Chang, PhD
Contact
sooeunc@umich.edu
734-232-0300
Emily Garnett, PhD
Contact
emilyog@umich.edu
734-232-3371
Soo-Eun Chang, PhD
principal investigator · University of Michigan

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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