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RecruitingNCT05286151Updated Oct 23, 2025

Network Connectivity and Temporal Processing in Adolescents Who Stutter

An interventional study of Rhythm discrimination in Stuttering, Childhood and Stuttering, sponsored by University of Michigan. Recruiting at 1 site in United States. Open to participants aged 9 Years to 13 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-23.

Sponsored by University of Michigan · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
500
Allocation
Non-randomized
Ages
9 Years to 13 Years
Sex
All
01

Study summary

The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

Read the detailed description

Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.

02

Conditions studied

  • Stuttering, Childhood
  • Stuttering

Keywords

  • Rhythm
  • Temporal processing
  • Healthy children
  • Speech disorders
  • Timing
03

Who can participate

Ages eligible
9 Years to 13 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion Criteria Children who stutter:

  • English as primary language
  • Current or past stuttering diagnosis

Inclusion Criteria Children who do not stutter:

  • English as primary language

Exclusion Criteria Children who stutter:

  • Diagnosed/under treatment for any neurological or psychiatric conditions
  • Head trauma with loss of consciousness
  • Major medical illness
  • Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments)
  • Face, motor, or reflex abnormalities

Exclusion Criteria Children who do not stutter:

  • Personal or family history of stuttering
  • Diagnosed/under treatment for any neurological or psychiatric conditions
  • Head trauma with loss of consciousness
  • Major medical illness
  • Hearing loss
  • Language/motor delay (below -2 standard deviations on standardized assessments
  • Face, motor, or reflex abnormalities
04

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
500 participants (estimated)

Study arms

  • Experimental
    Children who stutter

    Children who stutter

    Behavioral: Rhythm discrimination

  • Experimental
    Children who do not stutter

    Children who do not stutter

    Behavioral: Rhythm discrimination

Interventions

  • BehavioralRhythm discrimination

    Participants will complete a rhythm discrimination task once per year for 3 years.

05

What researchers measure

Primary outcomes

  1. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 1

  2. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 2

  3. Rhythm discrimination (d')

    Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

    Time frame: Year 3

06

Study locations

1 of 1 sites recruiting
  • University of Michigan
    Ann Arbor, Michigan 48109, United States
    • Soo-Eun Chang, PhD · Contact · sooeunc@umich.edu · 734-232-0300
    • Soo-Eun Chang, PhD · Principal investigator
    Recruiting
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT05286151
Lead sponsor
University of Michigan
Collaborators
National Institute on Deafness and Other Communication Disorders (NIDCD)
Responsible party
Soo-Eun Chang (Associate Professor of Psychiatry, University of Michigan) — Principal investigator
First posted
Mar 18, 2022
Start date
Jul 23, 2022
Primary completion
Jan 31, 2027 (estimated)
Completion
Jan 31, 2027 (estimated)
Last update
Oct 23, 2025

Study contacts

Soo-Eun Chang, PhD
Contact
sooeunc@umich.edu
734-232-0300
Emily Garnett, PhD
Contact
emilyog@umich.edu
734-232-3371
Soo-Eun Chang, PhD
principal investigator · University of Michigan

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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