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Not yet recruitingNCT07385781PsychosomaticUpdated Mar 18, 2026

Psychosomatic Symptoms in Patients With Myofascial Pain and Temporomandibular Joint Dysfunction

An observational study in Psychosomatic Symptoms and Temporomandibular Disorder (TMD), sponsored by Bahria University. Not yet recruiting at 1 site in Pakistan. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-18.

Sponsored by Bahria University · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2026, 4 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
300
Ages
20 Years to 60 Years
Sex
All
01

Study summary

Temporomandibular joint disorder poses an intricate etiology. Biomechanical, neuromuscular and psychosocial factors may contribute to the disorder among which psychological and psychosocial disturbances have shown strong direct or indirect contribution to the disease especially when the pain is of muscular origin.

Read the detailed description

Temporomandibular disorders (TMDs) are defined as the group of musculoskeletal and neuromuscular conditions that involves temporomandibular joint (TMJ), masticatory muscles, and their associated structures (1). Clinically, TMDs are characterized by jaw pain, mandibular movement limitation, joint sounds, and often referred pain in the head, neck, or shoulders region (2). The myofascial pain, a subtype of TMD, is most prevalent condition and it accounts for approximately 50% of all TMD cases in clinical settings (3). Although it's a prevalent condition, but its complex aetiology makes it difficult to diagnose (4).

02

Conditions studied

  • Psychosomatic Symptoms
  • Temporomandibular Disorder (TMD)

Keywords

  • Anxiety
  • Depression
  • myofascial facial pain
  • Perceived stress
  • Somatization
03

In context

Temporomandibular Joint Disorders

591 studies on the registry are indexed under Temporomandibular Joint Disorders; 149 are open to participants now.

This study's planned enrollment of 300 is above the median of 91 across 165 observational studies indexed under Temporomandibular Joint Disorders.

Browse Temporomandibular Joint Disorders studies →

Lead sponsor

Bahria University is the lead sponsor of 36 studies on the registry; 11 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Temporomandibular joint dysfunction patient

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

diagnosed patients with myofascial pain and TMD for at least six months based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), Axis I, age between 20 and 60 years, literate and able to comprehend the questionnaire no prior psychological treatment for pain.

Exclusion criteria

Exclusion Criteria:

age \<20 or >60 years, low literacy (less than five years of formal education), history of major psychiatric or neurological disorders, diagnosed joint pathologies (e.g., arthritis, disc displacement with reduction), history of migraine or facial trauma, drug dependency and pregnancy or current use of psychotropic medication.

05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
300 participants (estimated)
Patient registry
No

Groups and cohorts

  • Case

    A total of 300 participants aged between 20 and 60 years were recruited using survivor sampling, consisting of 150 patients with a confirmed diagnosis of myofascial pain and temporomandibular joint dysfunction (TMD) and 150 age- and gender-matched healthy controls

    Other: Casr

  • Control

    A total of 300 participants aged between 20 and 60 years were recruited using survivor sampling, consisting of 150 patients with a confirmed diagnosis of myofascial pain and temporomandibular joint dysfunction (TMD) and 150 age- and gender-matched healthy controls

    Other: Casr

Interventions

  • OtherCasr

    case study participants

06

What researchers measure

Primary outcomes

  1. Psychosomatic symptom burden

    Psychosomatic symptom burden is defined as the overall severity and frequency of physical symptoms that are influenced or maintained by psychological factors. It will be assessed using a validated self-report questionnaire that captures multiple somatic symptom domains (e.g., pain, gastrointestinal, cardiovascular, and fatigue-related symptoms). Higher scores indicate a greater psychosomatic symptom burden.

    Time frame: 2 months

07

Study locations

1 site
  • Bahria University
    Karachi, Pakistan
08

References and documents

Publications

  • 1. Szarejko KD, Gołębiewska M, Lukomska-Szymanska M, Kuć J. Stress experience, depression and neck disability in patients with temporomandibular disorder-myofascial pain with referral. Journal of Clinical Medicine. 2023;12(5):1988. 2. Kuć J, Szarejko KD, Maciejczyk M, Dymicka-Piekarska V, Żendzian-Piotrowska M, Zalewska A. Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disorder-Myofascial pain with referral. Frontiers in Neurology. 2025;15:1509845. 3. Gomes AKP, Ximenes TA, Fonseca APR, de Barros Silva PG, Magalhães IA, da Silva Rodrigues AK, et al. Relationship between temporomandibular joint dysfunctions and psychosomatic factors. Revista Eletrônica Acervo Saúde. 2024;24(5):e16019-e. 4. Syroishko M, Kostiuk T. Dysfunction of the temporomandibular joints associated with post-traumatic stress disorders in patients. Reports of Vinnytsia National Medical University. 2023;27(2):253-7. 5. Matos M, Thumati P, Sutter B, Ruiz-Velasco G, Goldberg J, Booth J, et al. Are Temporomandibular Disorders Really Somatic Symptom Disorders? Part II-Joint Vibration Analysis of the Temporomandibular Joint. Advanced Dental Technologies & Techniques. 2021. 6. Patil DJ, Dheer DS, Puri G, Konidena A, Dixit A, Gupta R. Psychological appraisal in temporomandibular disorders: A cross-sectional study. Indian Journal of pain. 2016;30(1):13-8. 7. Canales GDLT, Guarda-Nardini L, Rizzatti-Barbosa CM, Conti PCR, Manfredini D. Distribution of depression, somatization and pain-related impairment in patients with chronic temporomandibular disorders. Journal of Applied Oral Science. 2019;27:e20180210. 8. Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, et al. Treatment and management of myofascial pain syndrome. Best Practice & Research Clinical Anaesthesiology. 2020;34(3):427-48. 9. Cao Q-W, Peng B-G, Wang L, Huang Y-Q, Jia D-L, Jiang H, et al. Expert consensus on the diagnosis and treatment of myofascial pai
  • Szarejko KD, Golebiewska M, Lukomska-Szymanska M, Kuc J. Stress Experience, Depression and Neck Disability in Patients with Temporomandibular Disorder-Myofascial Pain with Referral. J Clin Med. 2023 Mar 2;12(5):1988. doi: 10.3390/jcm12051988. PubMed 36902775 ↗

Individual participant data

Plan to share: Yes

Supporting information: Study protocol, Informed consent form, Clinical study report

Time frame: jan 2026-Dec2026

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07385781
Lead sponsor
Bahria University
Responsible party
Dr Rida Zulfiqar (Registrar, Bahria University) — Principal investigator
First posted
Feb 4, 2026
Start date
Mar 1, 2026 (estimated)
Primary completion
Jun 30, 2026 (estimated)
Completion
Aug 30, 2026 (estimated)
Last update
Mar 18, 2026

Study contacts

rida Zulfiqar, BDS
Contact
ridazul34@gmail.com
+923203409531
Arsalan Khalid, BDS
Contact
+923323110793
Rida Zulfiqar
principal investigator · Bahria University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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