An interventional study of Endovascular Revascularization and Endovascular Revascularization in Critical Limb Ischemia and Tibialis Vessels Occlusion, sponsored by Aswan University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-03.
Sponsored by Aswan University · Not applicable, Interventional, and Treatment
This study aims to Compare the outcomes of angioplasty for single tibial vessel occlusion versus multiple tibial vessel occlusions in patients with critical limb ischemia. Assess the effectiveness and safety of angioplasty in treating different extents of tibial vessel occlusions. Evaluate the impact of angioplasty on limb salvage rates, healing of ischemic wounds, and overall clinical improvement in patients with CLI.
This study demonstrates that in patients with chronic limb-threatening ischemia (CLTI), revascularization resulting in the patency of multiple tibial vessels is associated with significantly superior clinical outcomes compared to single-vessel patency. While both strategies were equally safe and technically feasible, the multiple-tibial-vessel (MTV) group achieved perfect limb salvage, higher primary patency, lower restenosis rates, and significantly better wound healing at six months. These findings underscore the importance of robust tibial runoff, supporting the "angiogenic reserve" concept where multiple patent vessels provide redundant perfusion pathways that enhance the durability of revascularization and promote tissue repair. Consequently, when anatomically feasible, treatment strategies should prioritize the establishment or preservation of multi-vessel tibial outflow to optimize limb salvage and functional recovery in this high-risk population.
343 studies on the registry are indexed under Chronic Limb-Threatening Ischemia; 70 are open to participants now.
This study's enrollment of 40 is below the median of 45 across 233 interventional studies indexed under Chronic Limb-Threatening Ischemia.
Browse Chronic Limb-Threatening Ischemia studies →Aswan University is the lead sponsor of 47 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Rutherford Class 5 and 6 Single or multiple occlusive infrapopliteal vessel lesions In-flow vessel (superficial femoral artery and popliteal artery) free from flow-limiting lesion or in-flow lesion correction with bypass or endovascular intervention during index procedure.
Exclusion Criteria:
Prior vascular intervention in target limb Technical/hemodynamic failure inflow occlusive disease. Patient with allergy to the contrast
Who undergo single tibial artery Endovascular Revascularization
Procedure: Endovascular Revascularization
Who undergo more than one tibial artery Revascularization
Procedure: Endovascular Revascularization
One would undergo single tibial artery Endovascular Revascularization
Also known as: Endovascular
Other would undergo multiple tibialis vessels Endovascular Revascularization
Salvageable of limb(( patients don't need for major amputation )) sabe limb from major amputation
Salvageable of limb
Time frame: 2years
Plan to share: Yes
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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Chronic Limb-Threatening Ischemia→
Aswan University