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AvailableNCT07346105Updated Sep 21, 2026

Orca-T Expanded Access Program Study for Patients With Advanced Hematologic Malignancies

An expanded access record providing Orca-T in Hematologic Malignancies, Acute Myeloid Leukemia and Acute Lymphoid Leukemia, sponsored by Orca Biosystems, Inc.. Available at 8 sites in United States. Per ClinicalTrials.gov, last updated 2026-09-21.

Sponsored by Orca Biosystems, Inc. · Expanded access

Study type
Expanded access
Access type
Treatment IND/protocol
Sex
All
01

Study summary

This study is not designed to test a hypothesis; rather, this study will provide patients with access to Orca-T if the commercial Orca-T product produced for them is deemed out of specification (OOS). Serious adverse events (SAEs) occurring during the safety reporting period (defined as the day the recipient receives the Orca-T HSPC drug product through day +365 after transplantation or until initiation of new anticancer therapy, whichever occurs sooner) will be reported.

02

Conditions studied

  • Hematologic Malignancies
  • Acute Myeloid Leukemia
  • Acute Lymphoid Leukemia
  • Myelodysplastic Syndrome
  • Mixed Phenotype Acute Leukemia

Keywords

  • Hematopoietic stem cell transplantation
  • Acute leukemia
  • Myelodysplastic syndromes
  • Matched related donor
  • Matched unrelated donor
  • Myelodysplastic syndrome
  • TREGZI
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All

Inclusion criteria

Recipients in this EAP must meet all of the following criteria:

  1. Commercial Orca-T was prescribed to the patient by their treating physician.
  2. The final manufactured Orca-T does not meet the commercial release specifications or is delivered past expiry.
  3. The final manufactured Orca-T is acceptable per joint assessment by Orca Bio and the treating physician, taking into account Orca Bio's release criteria.
  4. Remanufacturing (ie, repeat leukapheresis and manufacturing) is not clinically appropriate per the treating physician's assessment.
  5. Recipient must be deemed medically fit and stable to receive Orca-T infusions per the treating physician's evaluation.

Exclusion criteria

Exclusion Criteria:

Recipients with any medical condition identified by the treating physician that may impact the safety or outcomes of the recipient in relation to treatment with Orca-T will not be eligible.

04

Access details

Study type
Expanded access
Access type
Treatment IND/protocol

Available treatment

  • BiologicalOrca-T

    Orca-T that does not meet commercial release specifications

05

Where to request access

8 of 8 sites recruiting
  • UCLA Department of Medicine - Hematology/Oncology
    Los Angeles, California 90095, United States
    • Caspian Oliai, MD · Contact
    Available
  • Stanford Cancer Institute
    Palo Alto, California 94304, United States
    • Andrew Rezvani, MD · Contact
    Available
  • Moffitt Cancer Center
    Tampa, Florida 33612, United States
    • Nelli Benjanyan, MD · Contact
    Available
  • The University of Kansas Hospital
    Kansas City, Kansas 66160, United States
    • Joseph McGuirk, DO, FACP · Contact
    Available
  • Massachusetts General Hospital
    Boston, Massachusetts 02114, United States
    • Richard Newcomb, MD · Contact
    Available
  • Memorial Sloan Kettering Cancer Center
    New York, New York 10065, United States
    • Roni Tamari, MD, MS · Contact
    Available
  • The Ohio State University Wexner Medical Center - James Cancer Hospital
    Columbus, Ohio 43210, United States
    • Sarah Wall, MD, MPH · Contact
    Available
  • Baylor University Medical Center
    Dallas, Texas 75246, United States
    • Jana Reynolds, MD · Contact
    Available
06

References and documents

Publications

  • Meyer EH, Salhotra A, Gandhi AP, Pantin J, Patel SS, Hoeg RT, Gomez-Arteaga A, Faramand R, Tamari R, Waller EK, Kosuri S, Jimenez Jimenez AM, Holter-Chakrabarty J, Dholaria B, Chen YB, Hamilton BK, Magenau J, Eghtedar A, Murray JM, Pavlova A, Fernhoff NB, McClellan JS, Killian MS, Li A, Negrin RS, Oliai C. Orca-T vs allogeneic hematopoietic stem cell transplantation (Precision-T): a multicenter, randomized phase 3 trial. Blood. 2026 Mar 12;147(11):1168-1177. doi: 10.1182/blood.2025031313. PubMed 41385341 ↗
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Registry details

Key details

Study ID
NCT07346105
Lead sponsor
Orca Biosystems, Inc.
Responsible party
Sponsor
First posted
Jan 16, 2026
Last update
Sep 21, 2026

Study contacts

James S. McClellan, MD, PhD
Contact
info@orcabio.com
530-414-9723
Anna Pavlova, MD, PhD
Contact
info@orcabio.com
530-414-9723
View the source record on ClinicalTrials.gov ↗

Requesting access

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