Leukemia, Biphenotypic, Acute clinical trials
The registry lists 246 studies for Leukemia, Biphenotypic, Acute across more than 10 countries. 56 are recruiting or about to start. 62 of them are mainly about Leukemia, Biphenotypic, Acute (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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· Enrollment: 300 → 450 participants
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Who runs them
Fred Hutchinson Cancer Center (32) · M.D. Anderson Cancer Center (22) · National Cancer Institute (NCI) (18) · Children's Oncology Group (14) · Memorial Sloan Kettering Cancer Center (10) · St. Jude Children's Research Hospital (7) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6) · European Organisation for Research and Treatment of Cancer - EORTC (5)
What is being tested here
Drugs under test in Leukemia, Biphenotypic, Acute studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fludarabine | 7 | 1 | 26 |
| Cyclophosphamide | 6 | 1 | 23 |
| Venetoclax | 6 | 0 | 13 |
| Revumenib | 6 | 0 | 8 |
| Cytarabine | 4 | 0 | 14 |
| Blinatumomab | 4 | 2 | 8 |
| Azacitidine | 3 | 0 | 8 |
| Cladribine | 3 | 0 | 7 |
| Idarubicin | 3 | 0 | 4 |
| Fludarabine phosphate | 2 | 1 | 14 |
Drug classes tested here Antimetabolites 18 open · Alkylating agents 9 open · Tyrosine kinase inhibitors (TKIs) 4 open · Corticosteroids 3 open · Antimitotic agents 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia · Phase 3 · Princess Maxima Center for Pediatric Oncology
- Dec 2026Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT · Stanford University
- Dec 2026HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis · Center for International Blood and Marrow Transplant Research
- Dec 2026Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting · M.D. Anderson Cancer Center
- Dec 2026HVA in the Treatment of Mixed-Phenotype Acute Leukemia(MPAL). · Guangdong Second Provincial General Hospital
- Jan 2027Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia · St. Jude Children's Research Hospital
- Feb 2027CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia · Fred Hutchinson Cancer Center
- Apr 2027Venetoclax + Azacytidine for Newly Diagnosed ETP-like ALL and T-ALL With Myeloid Mutations · yuejun Liu
- Apr 2027Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies · Fred Hutchinson Cancer Center
- May 2027MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing · Medical College of Wisconsin
Who these studies take
Of the 49 Leukemia, Biphenotypic, Acute studies recruiting now, 21 (43%) set no upper age limit and 22 (45%) stop at 75 or younger. 30 (61%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 19 (39%) | 19 (39%) |
| 18 | 46 (94%) | 46 (94%) |
| 30 | 38 (78%) | 38 (78%) |
| 40 | 37 (76%) | 37 (76%) |
| 50 | 36 (73%) | 36 (73%) |
| 65 | 35 (71%) | 35 (71%) |
| 75 | 31 (63%) | 31 (63%) |
| 85 | 24 (49%) | 24 (49%) |
Across all 246 studies, recruiting or not: 49% stop at 75 or younger and 37% at 65; 58% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, Biphenotypic, Acute studies take
Of 42 phase 2 interventional studies under Leukemia, Biphenotypic, Acute, half reached primary completion within 102 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 70 mo29–98 · 27 studies | — | — |
| Phase 2 | 102 mo47–153 · 42 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Prophylactic DLI-X for Leukemia Relapse After HCTOct 29, 2026NCT07254793
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 246. Browse all 246 → or search them.
- Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid NeoplasmsRecruitingNCT04797767Phase 1/21 country
- A Study to Assess the Pharmacokinetics and Safety of Revumenib in Participants With Advanced Cancer and Hepatic or Renal ImpairmentNot yet recruitingNCT07923071Phase 1
- Personalized NK Cell Therapy in CBTRecruitingNCT02727803Phase 21 country
- Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)RecruitingNCT05322850Phase 1/21 country
- Prophylactic DLI-X for Leukemia Relapse After HCTRecruitingNCT07254793Phase 11 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged LeukemiaRecruitingNCT06317662Phase 22 countries
- Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic DiseasesRecruitingNCT06013423Phase 21 country
- Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)RecruitingNCT06533579Phase 1/21 country
- Real World Asparaginase Therapy ToxicityNot yet recruitingNCT070080271 country
- Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid LeukemiaRecruitingNCT06177067Phase 11 country
- A Study of Revumenib and Mezigdomide in People With LeukemiaRecruitingNCT07356154Phase 1/21 country
- Randomization for the Identification of Best Treatment Intensity for Less Fit Adults With Acute Myeloid Leukemia and Myeloid NeoplasmsRecruitingNCT07094750Not applicable1 country
- Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell TransplantRecruitingNCT06575296Phase 11 country
- Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute LeukemiaRecruitingNCT05327894Phase 324 countries
- Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More TreatmentNot yet recruitingNCT07636564Phase 2
- A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 MutationRecruitingNCT04065399Phase 1/211 countries
- A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesRecruitingNCT03802695Phase 11 country
- Orca-T Expanded Access Program Study for Patients With Advanced Hematologic MalignanciesAvailableNCT073461051 country
- CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic LeukemiaRecruitingNCT04375631Phase 11 country
- Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene MutationRecruitingNCT03683433Phase 21 country
- Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic SyndromeNot yet recruitingNCT07819396Phase 21 country
- Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic MalignanciesNot yet recruitingNCT07710781Not applicable
- Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLyRecruitingNCT03959085Phase 35 countries
- The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group StudyRecruitingNCT04726241Phase 1/25 countries
- Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)RecruitingNCT06390319Phase 21 country
- Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid CancerRecruitingNCT07046078Phase 21 country
- Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/LymphomaRecruitingNCT06289673Phase 41 country
- Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic SyndromeRecruitingNCT07216443Phase 21 country
- Allo HSCT Using RIC and PTCy for Hematological DiseasesRecruitingNCT05805605Phase 21 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCTRecruitingNCT06551584Phase 11 country
- 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute LeukemiaRecruitingNCT03128034Phase 1/21 country
- 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic SyndromeRecruitingNCT03670966Phase 1/21 country
- Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic SyndromeRecruitingNCT04047641Phase 1/21 country
- Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological MalignanciesRecruitingNCT04195633Phase 21 country
- Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid LeukemiaRecruitingNCT02115295Phase 21 country
- HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell TransplantRecruitingNCT03326921Phase 11 country
- Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of RelapseRecruitingNCT06928662Phase 1/21 country
- MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG DosingRecruitingNCT05794880Not applicable1 country
- Leukemia Stem Cell-based Assay to Predict Relapse and Survival in Patients With Acute Myeloid LeukemiaRecruitingNCT075377381 country
- The OPAL Study: AVM0703 for Treatment of Lymphoid MalignanciesRecruitingNCT04329728Phase 1/21 country
- Subcutaneous Blinatumomab for Treatment of Adult Patients With CD19-Positive Mixed Phenotype Acute Leukemia (MPAL)RecruitingNCT07222579Phase 21 country
- HVA in the Treatment of Mixed-Phenotype Acute Leukemia(MPAL).Enrolling by invitationNCT07517510Phase 21 country
- Venetoclax Basket Trial for High Risk Hematologic MalignanciesRecruitingNCT05292664Phase 11 country
- Pharmacokinetic and Safety Study of MRX-2843 in Adolescents and Adults With Relapsed/Refractory AML, ALL, or MPALRecruitingNCT04872478Phase 11 country
- Venetoclax Combined With Azactidine in the Treatment of ALALRecruitingNCT05901974Phase 21 country
- Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell TransplantationRecruitingNCT07256210Phase 21 country
- Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous LineageRecruitingNCT04440267Phase 21 country
- Venetoclax + Azacytidine for Newly Diagnosed ETP-like ALL and T-ALL With Myeloid MutationsRecruitingNCT07012447Phase 21 country