ClinicalTrials.gg
RecruitingNCT07303725Updated Dec 26, 2025

Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology

An observational study in Liver Cancer (Primary and Metastatic) and Renal Cancer, sponsored by Palo Alto Veterans Institute for Research. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-26.

Sponsored by Palo Alto Veterans Institute for Research · Observational

From the registry’s dates

  • Primary completion was expected by Feb 2026, 9 months ago, but the record still lists the study as recruiting.
  • Started Feb 2025; still recruiting 1 year 9 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
30
Ages
18 Years and older
Sex
All
01

Study summary

This is a pilot study to evaluate the feasibility, image quality, and procedural utility of a novel spectral CT technique using Canon Medical's 4D CT system during image-guided interventional oncology procedures

Read the detailed description

The aims of this study are:

  1. Demonstrate the feasibility of acquisition and image quality of intra-arterial spectral CT images obtained during mapping arteriography prior to trans arterial radioembolization (TARE) for liver cancer treatment.

    1. Assess the procedural utility of Spectral CT images as part of the TARE workflow, such as hepatopulmonary shunt fraction estimation, lesion identification, prediction of tumor: normal liver (T:N) dose ratio, and dose distribution
    2. Investigate the feasibility, safety, and image quality of Spectral CT images obtained during tumor ablation.
  2. Explore the feasibility of assessing physiologic tissue changes using Spectral CT (effective anatomic number maps)

    1. During ablation with microwave, cryoablation, and irreversible electroporation in an ex vivo model
    2. For image-guided tumor ablation, such as lesion identification, probe placement, and ablation monitoring.
02

Conditions studied

  • Liver Cancer (Primary and Metastatic)
  • Renal Cancer

Keywords

  • spectral CT
03

In context

Liver Neoplasms

1,345 studies on the registry are indexed under Liver Neoplasms; 335 are open to participants now.

This study's planned enrollment of 30 is below the median of 200 across 342 observational studies indexed under Liver Neoplasms.

Browse Liver Neoplasms studies →

Lead sponsor

Palo Alto Veterans Institute for Research is the lead sponsor of 53 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

patients with liver or kidney cancer being treated at VAPAHCS

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age > or = 18 years
  2. Tumor in an area without prior surgical or ablative therapy
  3. At least 1 tumor greater than 1.5 cm in greatest diameter

Exclusion criteria

Exclusion criteria:

  1. Not eligible for indicated procedure.
  2. > 35
  3. Prior surgery.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
30 participants (estimated)
Patient registry
No

Groups and cohorts

  • angiography mapping

    Hepatocellular carcinoma (HCC) patients undergoing hepatic angiography mapping prior to TARE (N=10)

  • microwave ablation

    percutaneous tumor ablation in patients receiving image-guided tumor ablation using MWA (n=10)

  • cryoablation

    cryoablation (N=10) for primary liver (HCC) or primary kidney tumors (RCC)

06

What researchers measure

Primary outcomes

  1. CT image

    Effective Dose and CTDI

    Time frame: Baseline

Secondary outcomes

  1. number

    Number of spectral CT acquisitions per patient

    Time frame: Baseline

  2. time

    Fluoroscopy Time

    Time frame: Baseline

07

Study locations

1 of 1 sites recruiting
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 26, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07303725
Lead sponsor
Palo Alto Veterans Institute for Research
Collaborators
Canon Medical Systems, USA
Responsible party
Sponsor
First posted
Dec 26, 2025
Start date
Feb 1, 2025
Primary completion
Feb 1, 2026 (estimated)
Completion
Sep 1, 2026 (estimated)
Last update
Dec 26, 2025

Study contacts

Sirish Kishore, MD
Contact
sirish.kishore@va.gov
650-493-5000 ext. 61706
Luisa Manfredi, MPH
Contact
luisa.manfredi1@va.gov
650-493-5000 ext. 61706
Sirish Kishore, MD
principal investigator · VA Palo Alto Health Care System

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion