An interventional study of ONSD+AF in Pre-Eclampsia, sponsored by Saint Thomas Hospital, Panama. Completed at 1 site in Panama. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-16.
Sponsored by Saint Thomas Hospital, Panama · Not applicable, Interventional, and Diagnostic
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Refining the diagnostic capability of this test would further improve maternal-fetal outcomes and the use of optic nerve sheath diameter (ONSD) measurement could make the difference.
The purpose of the present study is to correlate the measurement of ONSD with serum angiogenic factor (AF) values in patients with pre-eclampsia and to determine its predictive ability for adverse perinatal outcomes.
916 studies on the registry are indexed under Pre-Eclampsia; 243 are open to participants now.
This study's enrollment of 200 is above the median of 110 across 480 interventional studies indexed under Pre-Eclampsia.
Browse Pre-Eclampsia studies →Saint Thomas Hospital, Panama is the lead sponsor of 37 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Subjects admitted with severe pre-eclampsia, based on the criteria by the American College of Obstetricians and Gynecologists (ACOG)
Procedure: ONSD+AF
Subjects admitted for normal labor, without any criteria of pre-eclampsia
Procedure: ONSD+AF
Measurement of the optic nerve sheath diameter and of sFLT-1/PGIF index
Optic nerve sheath diameter cut off value
Value in mms of the optic nerve sheath diameter for the diagnosis of severe preeclampsia
Time frame: Up to discharge. On average, 7 days.
sFLT-1/PiGF index
Value of the index between the sFlt-1/PIGF (angiogenic factor) for the diagnosis of severe preeclampsia
Time frame: Up until discharge. On average, 7 days
Maternal/fetal morbidity
Presence of any/several indicators of maternal or fetal morbidity (abruptio placenta, HELLP syndrome, eclampsia, fetal growth restriction, acute lung edema).
Time frame: Up until discharge. On average, 7 days
Neonatal morbidity
Presence of any/several indicators of neonatal morbidity (Apgar scores, admission to NICU, encephalophatic hypoxia)
Time frame: Up until discharge. On average, 3 days
Plan to share: No
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This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Saint Thomas Hospital, Panama