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CompletedNCT07245719UMFUpdated Apr 22, 2026

Stryker Universal Midface and Upper-Face Fixation System: A Retrospective Post Market Follow Up

An observational study in Zygomatic Fractures, Orbital Fractures and Maxilla Fractures, sponsored by Stryker Craniomaxillofacial. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2026-04-22.

Sponsored by Stryker Craniomaxillofacial · Observational

Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
150
Sex
All
01

Study summary

A retrospective post-market clinical follow-up to confirm the performance and safety of the Upper-Face and Mid-Face modules of the Stryker Universal CMF System in a clinical setting. The study is performed to confirm the product's performance and safety by systematically collecting clinical data on its use.

Read the detailed description

This is a retrospective non-interventional post-market follow up aiming at confirming safety and performance of the Stryker Universal System when used in a clinical setting. This study will include patients who have previously undergone a surgical procedure involving the Study Device, with surgical outcomes evaluated retrospectively. Based on a non-inferiority study power calculation a minimum of 120 patients will be enrolled in the study. Additional patients may be enrolled up to 150 subjects depending on site enrolment rate and patient availability. Up to 2 investigational sites within the United States will participate in this study. The primary outcome parameter evaluating successful stabilization and/or fixation of bony segments without the need for unplanned revision surgery will be evaluated at all available follow-up timepoints of the included patients.

02

Conditions studied

  • Zygomatic Fractures
  • Orbital Fractures
  • Maxilla Fractures
  • Facial Fractures

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03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Eligible patients will be identified as having had a surgical procedure involving the Subject Device.

Inclusion criteria

  1. Skeletally mature patients at the time of surgery.
  2. Patients who underwent a craniomaxillofacial procedure using implants of the Upper-Face and/or Mid-Face modules (1.2 / 1.7 modules) of the Stryker Universal CMF System as per routine clinical practice.
  3. Patients for whom data on the primary outcome variable is available.
  4. Patients with data available from follow-up visits.

Exclusion criteria

Exclusion Criteria:

  1. Patients with active infections at the time of surgery.
  2. Patients with known metal allergies and/or foreign body sensitivity at the time of surgery.
  3. Subjects with non-reducible and unstable fractures (except reconstruction plates) at the time of surgery that were treated with the subject devices.
  4. Patients who underwent secondary reconstructions with non-secondary reconstruction plates
  5. Patients with limited blood supply or insufficient quality or quantity of bone at the time of surgery.
04

Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
150 participants (actual)
Patient registry
No

Interventions

  • DeviceUpper-Face and/or Mid-Face modules (1.2 / 1.7 modules) of the Stryker Universal CMF System

    The Universal CMF System is a plate and screw system intended for osteotomy, stabilization, and rigid fixation of CMF fractures and reconstruction. Depending on the selected module, the design of the devices is more suitable for specific indications within the broad indication of CMF fractures and CMF reconstructive surgeries.

05

What researchers measure

Primary outcomes

  1. Successful stabilization and/or fixation of bony segments without the need for unplanned revision surgery

    Assessed by reviewing adverse events in patient medical charts at time point after surgery. Used to document whether an unplanned revision surgery was required or not for patients.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

Secondary outcomes

  1. Intraoperative complications

    Determined by intraoperative adverse events reported from patient medical charts.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  2. Postoperative complications

    Determined by post operative adverse events reported from patient medical charts.

    Time frame: Data collected at time points per patient in the course of 12 months.

  3. Any known adverse events potentially related to the primary outcome objective and/or device

    Determined by adverse events reported from patient medical charts.

    Time frame: Data collected at time points per patient in the course of 12 months.

  4. Implant failure

    Determined by adverse events reported from patient medical charts.

    Time frame: Data collected at time points point per patient in the course of 12 months.

  5. Operating room (OR) time

    Time patients are operated (dd:hh)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  6. Hospitalization time

    Time the patient was hospitalized post procedure (ICU and normal ward; dd:hh)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  7. Post-operative bone consolidation

    Clinical observation of post-op bone consolidation (medical charts) Timing of post-op observation of bone consolidation (yymmdd) Availability of post op imaging to determine bone consolidation Timing of post-op imaging (number of scans, yymmdd)

    Time frame: Data collected at time points point per patient in the course of 12 months.

Other outcomes

  1. Age

    Patient age (year of birth, age in years)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  2. Primary indication for the surgery / diagnosis

    Diagnosis collected from patient medical charts

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  3. Surgical approach/access

    Surgical approach taken for the procedure. Including: orthognathic, trauma, oncological, congenital defect, other. Usage of the device in the maxilla and maximal incisal mouth opening (post- and pre-operation). Application of post-operative Maxillo-Mandibular Fixation

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  4. Anatomical area treated

    Area to treated by the device: orbital region, zygomatic region, dento-alveolar region, maxilla, frontal region, other.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  5. Other implants used

    Other implants that may have been used during the surgical procedure.

    Time frame: Data collected at time points per patient in the course of 12 months.

  6. Max follow-up time

    Maximum post operative follow up time for patients within standard of care. Reported in patient medical charts during hospital follow up visits.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  7. Orthognathic cases

    Satisfactory occlusion expected to be achieved after potential additional orthodontic treatment.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  8. Patient Radiation Exposure

    Exposure of patient to radiation therapy within 12 months around the surgery date recorded in patient medical charts (number and type of radiation procedures performed). Radiation therapy performed on the anatomical area treated with the device. Any postoperative radiation therapy recorded in patient medical charts.

    Time frame: Data collected at time points per patient in the course of 12 months.

  9. Sterilization method used

    Sterilization method used for the device. Qualitative responses from site.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  10. Tightening of screws

    Tools used to fix the device during the procedure. Manually, electric screw driver

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  11. Implants Used

    Quantity, part numbers \& descriptions of implants used from the device.

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  12. Gender

    Patient gender (Male, Female, undifferentiated, unknown)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  13. Height

    Patient height (cm, feet, inches)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  14. Weight

    Patient weight (kg, lb)

    Time frame: Data collected at a single time point per patient in the course of 12 months.

  15. Year smoking was stopped

    Year smoking was stopped (YYYY)

    Time frame: Data collected at time points per patient in the course of 16 months.

  16. Smoking frequency

    The frequency of exposure to smoking during periods of smoking (average number of cigarettes per day).

    Time frame: Data collected at time points per patient in the course of 12 months

  17. Smoking duration

    Duration of smoking (pack years)

    Time frame: Data collected at time points per patient in the course of 12 month

  18. Years of active smoking

    Total number of years active smoker (YY)

    Time frame: Data collected at time points per patient in the course of 12 months

06

Study locations

1 site
  • Weill Cornell Medicine Oral and Maxillofacial Surgery 525 East 68th Street, F-2132
    New York, New York 10065, United States
07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07245719
Lead sponsor
Stryker Craniomaxillofacial
Responsible party
Sponsor
First posted
Nov 24, 2025
Start date
Mar 28, 2025
Primary completion
Mar 27, 2026
Completion
Mar 27, 2026
Last update
Apr 22, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
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